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One therapy to treat them all? study tests single approach for PTSD, anxiety, and depression in veterans

NCT ID NCT04293341

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single therapy (Transdiagnostic Behavior Therapy) works as well as separate, disorder-specific therapies for veterans with PTSD, major depression, or panic disorder. 304 veterans participated, and researchers measured symptoms before, during, and after treatment, plus at a 6-month follow-up. The goal is to see if one streamlined approach can replace the need for multiple specialized treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transdiagnostic Behavior Therapy (TBT) and Cognitive Processing Therapy (CPT)
What this could lead to
If successful, this could show that one therapy can effectively treat multiple mental health conditions, making treatment simpler and more accessible for veterans.
What could go wrong
This is a completed study, so results are available but may not apply to all veterans. The therapies are behavioral, not drugs, so effects depend on patient engagement and therapist skill.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

304 people

The number who actually took part.

Started

Oct 2020

Finished

Mar 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must be Veterans * Participants must be clearly competent to provide informed consent for research participation * Participants must meet DSM-5 criteria for panic disorder, major depressive disorder, or posttraumatic stress disorder * Participants must be 18-80 years old Exclusion Criteria: * recent history (\< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record or reported during clinical interview * acute, severe illness or medical condition that likely will require hospitalization and/or otherwise interfere with study procedures as documented in their medical record (e.g., active chemotherapy/radiation treatment for cancer), * recent start of new psychiatric medication (\< 4 weeks) * diagnosis of moderate-to-severe traumatic brain injury in their medical record and/or endorsement of screener questionnaire * additional comorbid psychiatric diagnoses that were not listed as exclusion criteria are permitted as long as they are considered secondary to the principal diagnosis of MDD, PTSD, or PD/AG as determined by the diagnostic interview * ineligible Veterans will be referred for non-study-related treatments within mental health at the RHJ VAMC

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Conditions

The condition(s) this trial relates to.

agoraphobia major depressive disorder panic disorder panic disorder with agoraphobia post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder Panic disorder and agoraphobia Posttraumatic stress disorder

Contacts and locations

Locations

  • Ralph H. Johnson VA Medical Center, Charleston, SC

    Charleston, South Carolina, 29401-5703, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.