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Caffeine's brain effects on panic disorder revealed in new study

NCT ID NCT06145490

Knowledge-focused Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how a 250 mg caffeine pill (about 2-3 cups of coffee) affects anxiety, decision-making, and body awareness in 42 people—some with panic disorder and some healthy. Participants took caffeine or a placebo on different days while having their brain scanned in a powerful 7T MRI. The goal was to understand the brain mechanisms behind caffeine-induced anxiety and panic attacks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
caffeine
What this could lead to
If successful, this could help explain why caffeine triggers anxiety in some people and point toward personalized advice for those with panic disorder.
What could go wrong
This is a small, completed study with only 42 participants. Results may not apply to everyone, and the findings are about understanding mechanisms, not a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Oct 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Panic Disorder group (PD): Primary diagnosis of Panic Disorder. * Healthy control group (HCs): No current or history of psychiatric disorders. * All participants (PD and HCs): Weekly caffeine consumption ≤ 300 mg. Exclusion Criteria: * Weekly caffeine consumption ≥ 300 mg. * Thoracic or head surgery, or any other surgery or metallic implanted devices not compatible with the safety standards for 7T MR scanner. * History of severe psychiatric disorder (e.g., schizophrenia). * Somatic or neurological conditions (e.g., hypertension and heart condition). * Ongoing treatment with psychotropic medication or treatment with psychotropic medication which has been discontinued within 2 months. * Other ongoing treatments that may confound the results. * Current drug or alcohol abuse/dependency. * Habitual nicotine use. * Uncorrected visual or hearing impairment. * Pregnancy.

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Conditions

The condition(s) this trial relates to.

panic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Panic disorder

Contacts and locations

Locations

  • National 7T Facility - Lunds universitet

    Lund, Sweden

  • Uppsala University, Department of Medical Sciences, Psychiatry

    Uppsala, 75185, Sweden

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