Osteoarthritis susceptibility 6

This study looked at how to best use antibiotics to prevent infections in people having knee replacement surgery. About 1,770 adults were split into groups that got antibiotics either just before surgery or for a full day after. The goal was to see if a single dose works as well …

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study compared two ways to perform partial knee replacement for osteoarthritis: using a robotic system (Navio) versus traditional manual tools. 66 adults with knee osteoarthritis took part. The goal was to see if robotic assistance leads to better leg alignment and implant p…

This study tests a new treatment called BRC-OA, made from donated human fat tissue, for people with mild to severe knee osteoarthritis. The goal is to see if it safely reduces pain and improves knee function. About 42 adults aged 18-80 will receive one of two doses or a control, …

This trial tests whether cooling and ablating genicular nerves before total knee replacement surgery can reduce post-operative pain and improve recovery. Participants will receive either unilateral or bilateral genicular nerve cooled radiofrequency ablation, followed by epidural …

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This study tested whether a health coaching program (called CAPPA) combined with a Fitbit could help employees with chronic knee pain become more physically active. Thirty-nine participants were split into two groups: one received physical activity coaching, the other received ge…

This early-phase trial tested a single injection of SYN321, a drug that breaks down into pain-relieving substances, in 35 people with painful knee osteoarthritis. The main goal was to check safety and tolerability at three different doses compared to a placebo injection. Research…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain control and getting patients moving sooner. One group got a fascia iliaca plane block, the other got a combination of adductor canal and IPACK blocks. Researche…

This study tested whether a special non-compressive bioactive garment helps people recover better than standard TED stockings after total knee replacement. Twenty-three patients wore either the new garment or the standard hose, and researchers measured pain, swelling, range of mo…

This pilot study tested whether a weight loss program before total knee replacement helps improve recovery. 24 adults with obesity (BMI 35-40) were assigned to either a very low-calorie diet with health coaching or standard care. The goal was to see if the program was feasible an…

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, whic…

This study tested a personalized web-based care plan for over 5,700 adults with knee or hip osteoarthritis. The goal was to help patients and their doctors make more informed decisions about treatments, including whether to have joint replacement surgery. The study measured how w…