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Can a Nerve-Freezing procedure transform knee replacement recovery?

NCT ID NCT06651762

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests whether cooling and ablating genicular nerves before total knee replacement surgery can reduce post-operative pain and improve recovery. Participants will receive either unilateral or bilateral genicular nerve cooled radiofrequency ablation, followed by epidural anesthesia and analgesia during and after surgery. The study measures pain control, functional outcomes, and knee range of motion to see if this approach enhances the multimodal pain management plan.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cooled radiofrequency ablation of genicular nerves (a procedure performed before knee replacement surgery)
What this could lead to
If effective, this procedure could reduce post-surgical pain, improve recovery, and shorten hospital stays for people undergoing total knee replacement.
What could go wrong
This is a small, early-stage trial, and results may not apply to everyone. The procedure carries risks such as nerve damage or infection, and it may not provide significant pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Oct 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:• Undergoing a scheduled unilateral total knee replacement surgery \- Exclusion Criteria: * • Allergy to any of the drugs used in the study * Alcohol or drug abuse * Psychiatric disease

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Conditions

The condition(s) this trial relates to.

osteoarthritis susceptibility 6 osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis of knee

Contacts and locations

Locations

  • faculty of medicine Ain Shams University

    Cairo, 02, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.