Opioid abuse

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra p…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study tests a program where pharmacists provide weekly phone coaching to adults who may be misusing opioid medications. The goal is to reduce risky opioid use and prevent addiction. 350 participants across 14 pharmacies are taking part in this randomized trial.

This study looks at ways to help people of color living in areas with high overdose rates start and continue medication-assisted treatment (MAT) for opioid or alcohol use. Researchers will track how many treatment sessions people attend and whether they stick with their medicatio…

This study tests whether a smartphone app can help people who are already on methadone treatment cut down on opioid and cocaine use. The app asks participants to take random drug tests at home and rewards them with money for negative results. Researchers want to see if app users …

This study tests whether a 90-day Mediterranean diet can lower drug cravings and improve blood health in people being treated for opioid addiction with methadone or buprenorphine. Forty adults will either follow the diet or eat as usual. The goal is to see if better nutrition can…

This study looked at whether giving a short-term buprenorphine treatment to people on probation or parole with opioid use disorder helps them stop using illegal opioids and get into long-term care. About 320 adults in Baltimore took part. The approach was compared to simply refer…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests whether providing HIV prevention (PrEP) and hepatitis C treatment together at one location works better than sending patients to separate clinics. About 446 people who inject drugs will be randomly assigned to either on-site integrated care or off-site referrals …

This study tests a program called TIARAS, which combines a reward system for staying drug-free and on PrEP (HIV prevention pills or shots) with expressive writing about past trauma. The goal is to see if this approach lowers HIV risk in women who inject drugs. 219 women from Phil…

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This study tests whether a numbing medicine injected around the cervix during vaginal hysterectomy for prolapse can lower pain and reduce the need for strong opioid painkillers afterward. About 56 participants will receive either the numbing medicine or a placebo (saltwater) inje…

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study tests whether a nerve block (bilateral superficial cervical plexus block) plus local anesthetic can reduce pain, nausea, and opioid use after thyroid surgery. 74 adults having a partial or total thyroid removal are randomly assigned to receive either the nerve block or…

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having heart surgery will receive either a long-acting or standard form of the numbing drug bupivacaine via ultrasound-guided injectio…

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having the surgery for non-cancer reasons will be randomly assigned to get a smaller or standard opioid prescription. The goal is to…

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study aims to find out how often cancer patients treated with opioids for pain are at risk of misusing these medications. Researchers will use two screening questionnaires to assess misuse risk in 200 adult outpatients receiving opioids for cancer-related pain. The findings …

This study develops and tests a computer tool that helps pharmacists screen patients for opioid medication risks. Researchers will compare pharmacies using the tool to those using standard care. The goal is to see if the tool lowers patients' risk of opioid abuse.

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study aimed to develop and test a smartphone app to help patients use, store, and dispose of opioid pain medications safely. It planned to include focus groups and a small trial with a reward system. However, the study was withdrawn before enrolling any participants, so no d…

This study looks at how patients use and store opioid pain pills after knee or hip replacement surgery, and whether teaching them about safe destruction helps. About 163 adults will get a special handout and a Deterra bag to destroy leftover pills. Researchers will call them 6-8 …

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV and opioid use disorder, people with only one of these conditions, and healthy volunteers. The goal is to understan…

This study was designed to see if giving methadone during breast reconstruction surgery helps patients use fewer opioids for pain afterward. It planned to enroll women having autologous breast reconstruction after mastectomy. However, the trial was withdrawn before any participan…