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Neck block may cut thyroid surgery pain and opioid use

NCT ID NCT05805423

Symptom relief Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a nerve block (bilateral superficial cervical plexus block) plus local anesthetic can reduce pain, nausea, and opioid use after thyroid surgery. 74 adults having a partial or total thyroid removal are randomly assigned to receive either the nerve block or a placebo injection, both with local wound infiltration. The goal is to see if the block improves recovery and quality of life in the first days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine
What this could lead to
If it works, this could offer a simple way to reduce pain and nausea after thyroid surgery, possibly lowering the need for opioids.
What could go wrong
This is a small, early-stage trial (74 people) testing a common procedure, so results may not be dramatic or widely applicable. The nerve block itself carries small risks like bruising or temporary nerve irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * undergoing thyroid surgery, either hemi- or total thyroidectomy * over 18 years-old and * able to consent for themselves Exclusion Criteria: * have had previous neck surgery * have coagulation disorders * on anticoagulants * are pregnant * allergic to bupivacaine * anyone with chronic pain conditions * has received steroid injections or used opioids/pain medications in the two weeks leading up to surgery * have a substernal goiters * undergoing lateral neck lymph node dissection * unable to take NSAIDs * kidney dysfunction (defined as GFR \<60) within 90 days of surgery, prohibiting the use of NSAIDs

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Conditions

The condition(s) this trial relates to.

opioid abuse Pain, Postoperative Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nausea and vomiting, postoperative Opioid use Post operative pain

Contacts and locations

Locations

  • UC Davis Medical Center

    Sacramento, California, 95817, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.