Open-angle glaucoma

This trial tests an implant called OTX-TIC, which is placed inside the eye and slowly releases travoprost, a drug that lowers eye pressure. The study includes adults with open-angle glaucoma or ocular hypertension, a condition of high pressure in the eye. Participants receive eit…

This trial compares two surgical procedures for people with primary open-angle glaucoma whose eye pressure stays high despite maximum medication. One group receives deep sclerectomy with scleral bed fenestration, a modified drainage surgery, while the other receives trabeculectom…

This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the metho…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This study tests a new preservative-free eye drop combination (QLS-111-FDC) to lower eye pressure in people with open-angle glaucoma or ocular hypertension. About 60 adults with mild to moderate disease will receive the treatment. The goal is to see if it safely reduces eye press…

This Phase 2 trial tests an experimental eye drop called BL1107 against a standard treatment (timolol) in 252 adults with glaucoma or high eye pressure. Participants use the drops twice daily for 28 days. The study measures changes in vision and eye pressure to see if BL1107 is s…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This study looked at whether placing a tiny device called iStent during cataract surgery helps lower eye pressure in people with primary open-angle glaucoma. Researchers compared 80 patients who got the implant plus cataract surgery to those who had cataract surgery alone. The go…

This completed trial tested the ELIOS System, a device used during cataract surgery to lower eye pressure in adults with mild-to-moderate open-angle glaucoma. The study enrolled 318 participants and measured how many achieved a 20% or greater drop in eye pressure without medicati…

This study tests a device called the ELIOS System to safely lower eye pressure in adults with mild to moderate open-angle glaucoma. The procedure is done alone, without other surgeries, and aims to reduce pressure by at least 20% while possibly using fewer medications. Researcher…

This study tested a new implant called PER-001 placed inside the eye to treat open-angle glaucoma. The trial included 33 adults and checked for safety and how well it controlled eye pressure. The implant is designed to release medication over time, potentially reducing the need f…

This study compared two small eye implants, Hydrus and iStent, placed during cataract surgery to help lower eye pressure in people with open-angle glaucoma. 65 patients were followed long-term to see which device worked better and was safer. The goal was to reduce the need for gl…

This study compared two treatments for advanced open-angle glaucoma: a gentle laser (subthreshold diode laser) and a surgical procedure (trabeculotomy). 80 adults with severe glaucoma that was not controlled by maximum medications took part. The goal was to see which treatment be…

This study tested a small implant called Supraflow v2.2 in 57 adults with open-angle or narrow-angle glaucoma. The implant is placed inside the eye to help drain fluid and lower eye pressure. The goal was to see if it safely reduces pressure and the need for daily eye drops over …

This study tested a new eye drop called Reformulated PG324 to see how well it lowers eye pressure in people with open-angle glaucoma or high eye pressure. About 489 adults took part. The goal was to measure the drop's safety and effectiveness in controlling eye pressure, which is…

This study tested a new eye drop called QLS-111 in 37 people with normal tension glaucoma, a type of glaucoma where eye pressure is not high but vision still gets damaged. The goal was to see if QLS-111 is safe and can lower eye pressure better than a standard drop called timolol…

This study tested a new, less invasive surgery called MIMS for people with glaucoma. The goal was to see if it lowers eye pressure as well as traditional surgery but with fewer side effects. 23 adults with glaucoma took part. The results will help doctors understand if MIMS is a …

This study looked at 70 people with mild to moderate glaucoma or high eye pressure. All received a laser treatment called selective laser trabeculoplasty (SLT). Afterward, half used Rocklatan eye drops and half used artificial tears. The goal was to see if Rocklatan lowered eye p…

This study tested a gel stent implant for open-angle glaucoma, a leading cause of blindness. 74 adults aged 45+ received the implant and were followed for 12 months. The goal was to safely lower eye pressure and reduce the need for glaucoma medications.

This study tested a modified surgical technique for open-angle glaucoma, adding a tiny mattress stitch to the standard deep sclerectomy procedure. 26 adults with glaucoma that was not controlled by eye drops were randomly assigned to receive either the standard or modified surger…

This study tested a new eye drop called SBI-100 in 56 adults with glaucoma or high eye pressure. Participants received either a low dose, high dose, or placebo drop twice daily for 14 days. Researchers measured how well the drops lowered eye pressure and checked for side effects.

This study tested a small device called the Hydrus Microstent in 217 adults with open-angle glaucoma that was not well controlled with other treatments. The goal was to see if the implant could safely lower eye pressure. After 12 months, many patients had a significant drop in ey…

This study tested two different laser treatment locations for open-angle glaucoma: one targeting the nasal side of the eye and one targeting the inferior side. 13 patients received the laser procedure to see which location better lowers eye pressure. The goal is to find the most …

This completed Phase 2 trial tested two strengths of a new eye drop called T4090 against the existing drug Rhopressa in 161 adults with open-angle glaucoma or ocular hypertension. The goal was to see which better lowers eye pressure over 7 weeks. Participants used one drop daily …

This completed Phase 4 trial tested the drug Mexidol in 80 people with advanced primary open-angle glaucoma. The goal was to see if the drug could improve the function of mitochondria in cells and protect the optic nerve. Participants were randomly assigned to receive Mexidol or …

This study tested different doses of the drug Mexidol in 102 adults with moderate to advanced open-angle glaucoma. The goal was to see if the drug could improve vision compared to a placebo. Participants took the drug or placebo in a sequence over several months, and their vision…

This early-stage study tested a tiny implant placed inside the eye that slowly releases medication to lower eye pressure in people with mild-to-moderate open-angle glaucoma. The goal was to find a dose that works well with few side effects. 37 adults took part, and researchers mo…

This phase 2 trial tested two new eye drop formulas, AR-17043 and PG043, in 426 people with open-angle glaucoma or ocular hypertension. The goal was to see if they safely lower eye pressure better than existing drops. Participants received different doses of the study drops or st…

This study looked at 100 adults with normal tension glaucoma who were already using the eye drop latanoprost. Researchers added either netarsudil or brimonidine to see which combination lowered eye pressure more effectively. The goal was to find a better way to control the diseas…

This study tested whether a daily oral solution containing citicoline and nicotinamide (Kron) could improve eye function in 30 people with open-angle glaucoma. Participants took the supplement and had their retinal and visual cortex activity measured. The goal was to see if the c…

This phase 3 trial tested whether a new eye drop called NCX 470 can lower eye pressure better than the standard drop latanoprost in people with open-angle glaucoma or ocular hypertension. About 696 participants used one drop in each eye every evening for up to 12 months. The stud…

This study tested a device that combines a bimatoprost implant with a special intraocular lens to treat both cataracts and glaucoma or high eye pressure. Twenty-four participants received the implant during cataract surgery. The main goals were to see if it lowers eye pressure an…

This study looked at whether people with glaucoma can use portable devices at home to check their eye pressure and vision. Over two years, 53 patients measured their eye pressure three times a day for a week every three months and tested their vision weekly. The goal was to see i…

This study compares two visual field tests used to monitor glaucoma: the current standard Humphrey Visual Field Analyzer and the newer iCare COMPASS. About 28 people with glaucoma or related eye conditions will take both tests in the same visit, with the order alternating between…

This study tested a new smart contact lens called miLens that records eye pressure patterns over 24 hours in 86 adults with glaucoma and healthy volunteers. Participants wore the lens in one eye and took smartphone readings every 15 minutes while awake. Researchers compared the l…

This study looked at whether a supplement called citicoline can improve vision in people with glaucoma after they have eye surgery. Six adults took either citicoline or a placebo for a short time. The goal was to see if citicoline could help protect the optic nerve and improve vi…

This study tested a mobile app that teaches Acceptance and Commitment Therapy (ACT) to help people with glaucoma cope with anxiety, depression, and emotional distress. Researchers worked with 28 patients to see if the app was acceptable and easy to use. The goal was to lay the gr…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study used MRI to measure blood flow in the eye's main artery in 20 adults with untreated glaucoma and compared it to healthy people. The goal was to understand how blood flow problems might contribute to glaucoma damage. Participants had one MRI scan, and no treatment was g…

This study looked at how the eye produces and drains fluid to understand why glaucoma medications lower eye pressure more in some people than others. Researchers measured eye fluid production, drainage, and pressure in 59 adults with glaucoma or high eye pressure before and after…

This study looked at 120 children with glaucoma or suspected glaucoma who needed eye exams under anesthesia. The goal was to see if a standard anesthesia plan could produce consistent and reliable eye pressure measurements. Researchers measured how deep the anesthesia was and com…

This study tested whether a simple app, available in English, Spanish, and Cantonese, could help glaucoma patients better remember their multiple eye drop schedules. Twenty participants either used the app or received standard instructions. After one month, researchers compared h…

This completed study tested NCX 470 eye drops in 18 healthy adults to see how they change fluid dynamics inside the eye. Participants received either the active drop or a placebo for 8 days. The goal was to measure fluid production, drainage, and pressure. Results will help resea…