Which laser best tames glaucoma pressure?
NCT ID NCT07756411
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the methods are equally effective at reducing eye pressure at 6 months. The study also tracks how much pressure drops, whether medication needs change, and any side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Laser trabeculoplasty (selective, micropulse, or pattern delivery)
- What this could lead to
- If one laser method proves better or equivalent, it could offer a more effective or safer way to control eye pressure and reduce reliance on daily glaucoma drops.
- What could go wrong
- This is a single-center trial with 90 patients, so results may not apply broadly. Laser treatment can cause temporary pressure spikes or inflammation, and the equivalence margin means differences might be small.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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90 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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May 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * adults with primary or secondary open-angle glaucoma. * gonioscopically open angle confirmed by gonioscopy in the study eye. * receiving intraocular pressure-lowering medication at entry, with an indication for subvisible laser trabeculoplasty according to standard practice at the unit (IOP inadequately controlled on medical therapy, intolerance of medical therapy, or both). * written informed consent. Exclusion Criteria: * previous laser trabeculoplasty, iridotomy or iridoplasty. * corneal disease precluding visualization of the trabecular meshwork or reliable applanation tonometry. * previous intraocular surgery other than uncomplicated cataract extraction. * systemic medication known to affect intraocular pressure. * pregnancy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Glaucoma Unit, Department of Medicine - Ophthalmology, University of Udine
Udine, UD, 33100, Italy
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Other studies related to the condition(s) this trial covers.
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