Ischemia reperfusion injury

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study tests whether using real-time measurements of oxygen levels in the brain and carbon dioxide in the breath can guide CPR more effectively than standard audiovisual feedback. Adults who have a cardiac arrest in the hospital and need CPR for at least five minutes may join…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study tested whether giving a single, strong dose of steroids to people right after a major heart attack (STEMI) could reduce the amount of heart muscle that gets permanently damaged. The steroid was given before the standard emergency procedure to open the blocked artery. T…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIC) could improve blood flow and reduce tissue damage in women undergoing breast reconstruction with a free flap. RIC involves using a blood pressure cuff on the upper arm to create short …

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study tested whether giving N-Acetylcysteine (NAC), a drug often used for coughs, directly into the heart arteries during emergency angioplasty can reduce damage caused by restoring blood flow. Researchers measured markers of stress, inflammation, and cell death in 70 heart …

This study looked at whether a specific heart procedure, done a few minutes after blood flow returns naturally, can limit heart muscle damage in people having a major heart attack. 72 adults with a first heart attack and partially open arteries took part. Researchers measured hea…

This study tested whether a single injection of cyclosporine, given right before opening a blocked artery, could improve outcomes for people having a major heart attack. About 970 patients received either cyclosporine or a placebo. Researchers tracked deaths, hospitalizations for…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study looked at 1,286 older adults or those with heart risks undergoing major liver surgery. It compared two methods of controlling blood flow to the liver to see which one causes less heart injury after surgery. The goal is to find safer surgical approaches and identify ris…

This study tested whether a simple procedure called remote ischemic preconditioning (RIPC) could improve healing of tissue flaps in head and neck cancer patients who had prior radiotherapy. RIPC involves briefly inflating a blood pressure cuff on the arm to create short periods o…

This completed study looked at 60 adults having leg surgery with a tourniquet to see if spinal or general anesthesia better maintains blood flow in the leg. Researchers used a light-based sensor to measure tissue oxygen levels. The goal was to understand which method might reduce…

This completed study compared two anesthesia methods—general anesthesia and infraclavicular block—in 106 adults undergoing upper arm surgery with a tourniquet. Researchers measured markers of oxidative stress and blood vessel function to see which method causes less damage. The g…

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This study in 18 rats investigates whether alpha lipoic acid, a natural antioxidant, can protect penile tissue from damage caused by restoring blood flow after a prolonged painful erection (priapism). Researchers will measure various markers of oxidative stress and inflammation i…

This study looked at 250 people who had a severe type of heart attack involving bleeding into the heart muscle. Researchers tested whether a measurement called the wall strain index ratio, taken from a heart MRI, could identify areas of the heart at risk of tearing (rupture). The…

This study looked at whether a technique called postconditioning, done during angioplasty to reopen blocked heart arteries, can reduce damage to the heart muscle. 44 adults having their first heart attack took part. The researchers used MRI scans to measure the area of blocked sm…

This study tested new MRI methods to detect bleeding inside the heart muscle after a heart attack. Researchers studied 14 patients to see if these scans could better identify damage that raises the risk of heart failure. The goal was to improve imaging, not to test a treatment.