Intracranial hypertension

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study looked at whether using a device to measure pressure inside the skull helps doctors treat people with a large brain bleed. 193 patients were randomly assigned to get either standard care or care guided by the pressure monitor. The goal was to see if the monitor helped …

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This study looked at 63 women having laparoscopic hysterectomy to see if two different anesthetics (sevoflurane and desflurane) affect pressure inside the head differently. The researchers measured the optic nerve sheath diameter using ultrasound as a non-invasive way to check br…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at 46 men having robot-assisted prostate surgery. Researchers tested two different carbon dioxide levels in the blood during surgery to see how they affect brain blood flow and pressure inside the skull. They also checked if these levels changed thinking skills …

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 …

This completed study looked at how a controlled increase in belly pressure (from laparoscopic surgery) affects a hormone called vasopressin and kidney function. Researchers measured pressure, optic nerve size, and urine output in 16 patients having weight-loss surgery. The goal w…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This study looked at 100 patients having a lumbar puncture (spinal tap) to measure pressure inside the skull. Researchers compared that pressure to each person's body fat percentage, measured using a special machine called a Bod Pod. The goal was to see if higher body fat is link…

This study looked at whether ultrasound measurements of the optic nerve sheath (the lining around the eye nerve) can detect increased brain pressure during laparoscopic (keyhole) surgery. Researchers measured the nerve sheath diameter in 55 adults undergoing laparoscopic surgery.…

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This study looked at how different ventilator pressure levels (PEEP) affect the optic nerve sheath diameter, which is a noninvasive way to estimate brain pressure. Researchers measured this in 105 patients undergoing spine surgery while lying face down. The goal was to see if hig…

This study looked at 53 adults having ear surgery (tympanoplasty) with their head turned to the side. Doctors used ultrasound to measure the optic nerve sheath diameter, which can indicate pressure inside the skull. The goal was to see if the sideways head position changes that p…

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study looked at 76 adults having gallbladder surgery to see if the gas pressure used in the belly affects the optic nerve sheath diameter, a non-invasive measure of brain pressure. Patients were randomly assigned to low (8 mmHg) or standard (14 mmHg) pressure. Researchers me…

This study looked at whether ultrasound measurements of the optic nerve sheath (the lining around the eye nerve) can detect changes in brain pressure during open-heart surgery when patients are on a heart-lung machine. Researchers measured the optic nerve sheath diameter in 40 ad…

This study tested a non-invasive helmet-like device to monitor brain pressure and detect tiny strokes in 60 hospitalized COVID-19 patients. The goal was to understand how COVID-19 affects the brain without using needles or surgery. Participants wore the device for one hour daily …