Intervertebral disk degenerative disorder

Researchers are studying a spinal implant called the EVOS Lumbar Interbody System, which uses PEEK-OPTIMA HA enhanced cages, in adults with degenerative disc disease or grade 1 spondylolisthesis in the lower back. The study follows participants who receive the device during spina…

This study tested a special spinal implant (the Keos Lumbar Interbody Fusion Device) in 25 adults with degenerative disc disease or related spine conditions. The goal was to see how well the device helped bones fuse and how it affected pain and quality of life. Participants had s…

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This study tested whether using a patient's own bone marrow stem cells (BMAC) mixed with donor bone works as well as the standard bone graft taken from the hip for spinal fusion surgery. Seventeen adults with degenerative disc disease were randomly assigned to one of the two meth…

This study looked at how well ViviGen, a bone graft made from donated human bone cells, helps fuse neck bones in people having 2- or 3-level neck surgery. 100 patients were followed to see if their bones fused and how their pain and function improved. The goal was to gather real-…

This study tested a new device called the HYDRAFIL system for people with long-term low back pain from worn-out spinal discs. 35 adults who had not gotten better with standard treatments received the implant. The main goal was to see if the device could be safely placed and help …

This study followed 361 adults with degenerative disc disease who had minimally invasive spinal fusion surgery. The goal was to see how well these procedures reduce disability and pain over 5 years. Researchers compared different surgical approaches to find which works best for p…

This study tested a new type of spine surgery called ILIF for people with degenerative disc disease, a condition where spinal discs wear down causing pain and nerve issues. 77 adults over 40 who had not improved with other treatments received the surgery. Researchers measured cha…

This study looked at whether a special bone graft called Osteocel Plus, which contains stem cells, helps the spine bones fuse together after surgery. It included 51 adults with degenerative disc disease who had not improved with other treatments. The goal was to see if this graft…

This study compared two surgical techniques for treating lumbar degenerative disc disease: traditional open surgery (open PLIF) and a newer, less invasive version (MAS PLIF). Researchers tracked complications and pain relief in 67 adults who needed spinal fusion. The goal was to …

This study tested Osteocel Plus, a bone graft material that contains stem cells, in 28 adults with degenerative disc disease who needed spinal fusion surgery. The goal was to see if it helps the spine bones fuse together as well as standard bone grafts. Researchers measured fusio…

This study tested Osteocel Plus, a special bone graft that contains stem cells, in 19 people with degenerative disc disease who needed spinal fusion surgery. The goal was to see if the graft helps bones fuse together as well as the standard method using the patient's own bone. Th…

This study looked at using Osteocel Plus, a bone graft material, in a type of spine surgery called XLIF for people with degenerative disc disease and back pain. 104 adults aged 18-80 who needed fusion of one or two lower spine segments were enrolled. The main goal was to see how …

This study looked at the safety and performance of two types of expandable spine implants (MLX and XLX ACR) in 109 adults with degenerative disc disease, spondylolisthesis, or scoliosis. Researchers tracked complications, bone fusion, and improvement in nerve symptoms after surge…

This study tested a new plate system used during spine fusion surgery in 75 adults with conditions like degenerative disc disease or scoliosis. The goal was to see if the plate is safe and helps bones fuse together properly. Researchers measured pain relief and fusion success ove…

This study looked at how safe and well a new spinal implant (Modulus ALIF System) works in 123 adults having back surgery. The patients had conditions like worn-out discs or slipped vertebrae. The main goals were to check for complications and see if the bones fused properly afte…

This study tested whether a man-made bone graft putty (AttraX) works as well as using the patient's own bone for spinal fusion surgery. 45 adults with degenerative spine conditions were enrolled. The main goal was to see if the putty helped bones fuse together just as well as the…

This study tested a new 3D-printed titanium implant for spine fusion surgery in 36 adults with degenerative disc disease, spondylolisthesis, or scoliosis. The implant is designed to help bones in the spine grow together after surgery. Researchers looked at safety, how well the bo…

This completed study tested two doses of the drug tranexamic acid (TXA) in 62 adults undergoing multilevel spinal surgery. The goal was to see which dose better reduces blood loss and the need for blood transfusions. Results could help surgeons choose the safest and most effectiv…

This early-stage trial tested an experimental treatment called IDCT (injectable disc cell therapy) in 38 people with chronic low back pain due to degenerative disc disease. Participants received either a low or high dose of the cell therapy or a sham procedure. The goal was to ch…

This study looked at how well a bone graft material called Natural Matrix Protein (NMP™) works in 53 patients who had spinal fusion surgery for degenerative disc disease. The main goal was to see if the bones fused properly on CT scans and X-rays. Researchers also measured change…

This study looked at different bone graft materials used during spinal fusion surgery for people with degenerative disc disease. About 119 patients were randomly assigned to receive either their own bone, a protein that stimulates bone growth, or one of three stem-cell-based graf…

This study compared two surgical approaches for people with a single level of lumbar spinal stenosis (a narrowed spine canal causing leg pain and trouble walking). 96 adults aged 40-75 were randomly assigned to receive either minimally invasive decompression and fusion or traditi…

This study compared two methods of pain control for people having back fusion surgery: a nerve block given before surgery versus numbing medicine injected at the end. Researchers measured pain, inflammation, confusion after surgery, and overall recovery in 29 adults. The goal is …

This completed study tested a nerve block called the erector spinae plane block in 40 adults with chronic low back pain from degenerative disc disease. The procedure aims to reduce pain and improve daily function. Researchers measured pain levels and disability scores to see if t…

This study looked at whether lumbar traction therapy (a device that gently pulls on the spine) can reduce pain and improve function in people with obesity and chronic low back pain. 49 participants received 30 minutes of traction daily for 4 weeks. Researchers measured pain, disa…

This study tested whether using a screening questionnaire called the STarT Back Tool helps doctors tailor low back pain treatment for military members. 290 adults aged 18-50 with low back pain were randomly assigned to either risk-stratified care or usual care. The goal was to se…

This study looked at 128 adults with back pain from a herniated disc. Researchers measured certain inflammation-related substances in the blood before and after physical therapy or a steroid injection. The goal was to see if these substances change with treatment and if they rela…

This study followed 50 people with chronic low back pain for 10 years after they had a procedure that punctured a spinal disc. Researchers used MRI scans to check if the punctured disc wore out faster than expected. The main goal was to see if the puncture itself caused extra dam…

This study tested whether an internet-based app could improve how well people follow their home rehabilitation exercises after lumbar disc surgery. One hundred adults aged 18 to 59 used the app, which sent reminders, exercise videos, and daily tips, and answered online surveys fo…

This study tested whether injecting a contrast dye into the disc space during TLIF spine surgery helps surgeons assess how well they have removed the disc. 56 patients having spinal fusion for degenerative spine disease were randomly assigned to either have the dye used as a chec…

This study looked back at 465 patients who had lumbar spine fusion surgery for degenerative disc disease. Researchers compared two types of implants (expandable cages and static cages) to see which ones were less likely to sink into the bone after surgery. The goal is to help sur…