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Minimally invasive back surgery may offer same benefits with fewer risks

NCT ID NCT01640977

Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two surgical techniques for treating lumbar degenerative disc disease: traditional open surgery (open PLIF) and a newer, less invasive version (MAS PLIF). Researchers tracked complications and pain relief in 67 adults who needed spinal fusion. The goal was to see if the less invasive approach could offer similar or better results with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Posterior lumbar interbody fusion (PLIF) surgery, either open or minimally invasive (MAS PLIF)
What this could lead to
If MAS PLIF proves safer or equally effective with fewer complications, it could become a preferred surgical option for patients with lumbar disc disease.
What could go wrong
This is a small, observational study (67 participants) comparing two surgical techniques, not a randomized trial. Results may not apply to all patients, and any surgery carries risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

67 people

The number who actually took part.

Start date

Jun 2012

Finished

Sep 2014

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Existing clinic patients

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects must meet all inclusion criteria to be eligible for enrollment into this observational study: 1. Indicated for posterior lumbar interbody fusion at one or two contiguous motion segments between L1 and S1; 2. 18+ years of age at the date of written informed consent; 3. Able to undergo surgery based on physical exam, medical history and surgeon judgment; 4. Willing and able to return for post-treatment exams according to the follow-up called for in the protocol; 5. Signed and dated informed consent form. Exclusion Criteria: * Subjects presenting with any of the following will not be included in this observational study: 1. Mental or physical condition that would limit the ability to comply with study requirements; 2. Spine abnormality requiring treatment at more than two levels; 3. Prior surgery at operative or adjacent level(s); 4. Involvement in active litigation relating to the spine (worker's compensation claim is allowed if it is not contested); 5. Significant general illness (e.g., HIV, active metastatic cancer of any type, uncontrolled diabetes, dialysis dependent renal failure, symptomatic liver disease); 6. Participating in another clinical study that would confound study data.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lumbar degenerative disc disease

Contacts and locations

Locations

  • Kuether Brain and Spine

    Greensboro, North Carolina, 27401, United States

  • Nova Neurosurgical Brain and Spine

    Greensboro, North Carolina, 27401, United States

  • Scott and White Healthcare

    Temple, Texas, 76508, United States

  • WellSpan Orthopedics-York

    York, Pennsylvania, 17405, United States

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