Back pain study probes Body's chemical signals during therapy
NCT ID NCT06545812
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 128 adults with back pain from a herniated disc. Researchers measured certain inflammation-related substances in the blood before and after physical therapy or a steroid injection. The goal was to see if these substances change with treatment and if they relate to pain relief and quality of life.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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128 people
The number who actually took part.
- Started
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Sep 2024
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Both sexes; age 18-70 years; * unilateral radicular pain of the lumbar segment; * diagnosis: intervertebral disc herniation; * confirmed diagnosis by clinical picture; * consent to participate in the study, which is confirmed by signing the informed consent; * unilateral lumbar radicular pain; * duration of pain up to six months; * symptomatic disc herniation at one level; * pain intensity measured by the VAS scale from 0 to 10, which is equal to or greater than 5; * pain intensity along the leg Exclusion Criteria: * patients younger than 18 or older than 70 years; * refusal of patients to participate in research; * patients with systemic, local infections in the area of the lumbar spine; * dermatological diseases in the area of the lumbar spine; * pregnancy; * central stenosis of the lumbar canal; * patients with bilateral radicular pain; * lumbar radicular pain caused by causes other than a herniated disc; * allergy to steroids, local anesthetics, fentanyl, midazolam and contrast media; * positive history of prolonged bleeding; * local or systemic infection; previous lumbar spine surgery; * abuse of opioids; * proven inflammatory rheumatic disease; * proven inflammatory bowel disease; * other infections.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Dental Medicine and Health Osijek
Osijek, 31000, Croatia
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