Infectious disorder of the nervous system

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This trial tests a new vaccine called LBVD, which combines protection against six diseases: diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib. The study enrolls healthy infants around 6 to 8 weeks old who receive three doses at 6, 10, and 14 weeks of age. Researche…

This early-stage trial is testing a new tetanus vaccine in 80 adults aged 18 and older. The study is randomized and double-blind, meaning neither participants nor doctors know who gets the new vaccine versus an existing one. The main goal is to check for side effects within the f…

This Phase 3 trial tests a new meningococcal conjugate vaccine in 660 healthy children aged 2-6 years. The vaccine targets four strains (A, C, Y, W135) that cause meningitis. Participants receive one shot and provide blood samples to compare immune response with a licensed vaccin…

This trial is testing an experimental vaccine made from virus-like particles (VLPs) that mimic polio viruses without causing disease. It aims to see if this vaccine is safe and triggers a strong immune response in healthy infants starting at 6 weeks old and toddlers aged 12-18 mo…

This study is testing a new vaccine called MenABCWY that aims to protect against five types of meningococcal bacteria, which can cause serious infections like meningitis. Around 312 healthy teenagers will receive two doses of the vaccine on different schedules to see how safe it …

This study tests the MenB+OMV NZ vaccine in 50 healthy infants starting at 2 months old in South Korea. The vaccine is given as three shots over about a year to see if it triggers a strong immune response against meningococcal group B bacteria, which can cause meningitis. Researc…

This phase 3 trial is testing whether simpler vaccination schedules for rabies are as effective as the standard 5-dose regimen. About 3,000 healthy people aged 10 to 60 will receive the vaccine in different patterns, including fewer total doses. Researchers will measure immune re…

This study tests a vaccine designed to protect young children from four types of meningitis bacteria. Researchers gave the vaccine to 660 toddlers aged 6 to 23 months and will check their immune response over time. Some children will also receive a booster shot at age 3 to see if…

This study tests a new rabies vaccine called ChAdOx2 RabG, given as a single shot. It involves 174 healthy adults (18-45 years) and young children (2-6 years) in a country where rabies is common. The goal is to see if the vaccine is safe and triggers a strong immune response, com…

This Phase 2 trial tests a new vaccine called MVA-BN-WEV to prevent two types of equine encephalitis (Eastern and Venezuelan), which are rare but serious brain infections spread by mosquitoes. The study involves 411 healthy adults aged 18-50 and aims to find the best dose and dos…

This phase 3 study tests a new vaccine (DTacP) that protects infants from diphtheria, tetanus, and whooping cough. Around 2,900 healthy babies aged 2-3 months will receive the vaccine to check its safety and how well it triggers immunity. The trial compares different schedules an…

This study tests a new drug called ION717 for people with early-stage prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce harmful prion proteins. The trial will check safety, side effects, and how the drug moves through the…

This Phase 3 trial tests satralizumab, an injected drug, in 120 people with NMDAR or LGI1 encephalitis—rare conditions where the immune system attacks the brain. The goal is to see if the drug improves disability and reduces the need for rescue treatments. Participants receive ei…

This phase 2 trial tests whether high-dose chemotherapy followed by a stem cell transplant can stop the immune system from attacking the nervous system in people with autoimmune neurologic diseases like multiple sclerosis and stiff person syndrome. The treatment aims to weaken th…

This early-stage study tests a new lab-made antibody injection against tetanus in 68 healthy adults aged 18-60. The main goal is to check safety and side effects, not to treat or prevent tetanus directly. Participants receive a single shot and are monitored for several weeks.

This study tests a new way to treat viral infections that often occur after a solid organ transplant. Researchers create special immune cells, called viral-specific T-cells, from the patient's own blood to fight the virus. The goal is to reduce the need for strong anti-viral drug…

This study checks how well a new test, the QIAstat-Dx ME Panel Plus, can detect meningitis and encephalitis from spinal fluid samples. Researchers will compare the test results to standard methods using leftover samples from 1500 patients. The goal is to see if the test works acc…

This phase 3 trial will give a single dose of the dTpa vaccine (Boostrix) to 95 healthy Japanese pregnant women between 27 and 37 weeks of pregnancy. The goal is to see if the vaccine triggers strong immunity in the mothers and passes protective antibodies to their babies at birt…

This trial tests different vaccination schedules for Japanese encephalitis in healthy children starting at 8 months old. Researchers compare how well each schedule triggers and maintains protective antibodies through age 6, including the effect of booster doses. The study also mo…

This study looks at whether a new antibody injection, called zamerovimab and mazorelvimab, combined with the standard rabies vaccine, can prevent rabies in people who have been severely bitten by a dog. The trial follows 80 adults in China for up to one year to see if they stay r…

This study tests a new rabies vaccine in 3,000 healthy people aged 10 to 60. The goal is to see how well it triggers the body's defenses and if it's safe. The vaccine is given in different schedules to find the best way to prevent rabies after a possible exposure.

This early-stage trial is testing the safety of a freeze-dried human rabies vaccine in 80 healthy people aged 10 to 60. Participants receive the vaccine in different schedules, and researchers monitor for side effects for 30 days after the last dose. The goal is to see if the vac…

Researchers are testing whether a virtual walking program can reduce chronic pain and psychological distress in people with severe mobility impairment, mostly from spinal cord injuries or polio. Participants wear a head-mounted display and use a controller to guide an avatar thro…

This study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…

This study looks back at medical records of 50 adults who had a shingles virus infection in their brain or spinal cord. Researchers want to find out what makes some people more likely to get these serious infections and what leads to long-term problems like memory loss or seizure…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study tracks 56 follicular lymphoma patients to see how long their COVID-19 and other vaccine immunity lasts while they receive chemotherapy and maintenance therapy. Researchers will collect blood samples at several time points to measure immune responses. The goal is to und…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study looks back at the medical records of 150 people diagnosed with Creutzfeldt-Jakob disease (CJD), a rare and fast-moving brain disorder. Researchers will examine symptoms, blood tests, spinal fluid, brain scans, and EEG results to find patterns that could help doctors di…

This study looks back at 4000 patients who had a suspected viral infection of the brain or spinal cord. Researchers will analyze which viruses were found and how the illness progressed in different groups, including children, adults, and people with weakened immune systems. The g…

This study is creating a large, long-term collection of blood samples and health information from over 3,200 people with multiple sclerosis and related demyelinating diseases, as well as healthy volunteers. The goal is to provide scientists with a shared resource to better unders…

This study reviews medical records of 200 people hospitalized with unexplained meningitis or meningoencephalitis. Researchers want to see if adding a test for tick-borne encephalitis (TBE) helps find more cases. No new drug or treatment is being tested—only the impact of a change…