Acute hemorrhagic leukoencephalitis
MONDO:0011716Acute hemorrhagic leukoencephalitis(AHL) is a veryrareform of acute disseminated encephalomyelitis that usuallyresults indeath. It is characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages the myelin -- the protective covering of the nerve fibers. It may also cause bleeding in the brain, leading to damage of the white matter. Symptoms usually come on quickly, beginning with symptoms such as fever, neck stiffness, fatigue, headache, nausea vomiting,seizures, and coma.AHL has a very poor prognosis, with rapid deterioration and death usually occurring within days to one week after onset of symptoms because of severe inflammation in the brain. Although the exact cause is unclear,AHL usually followsaviral infection, or less often, vaccination for measles, mumps, or rubella. Some researchers think that an infection or vaccination can initiate an autoimmune process in the body thus leading to AHL.
Also known as: AHL, acute hemorrhagic leukoencephalitis, AHLE, Ahl
10 clinical trials for this condition and its sub-types, 1 tagged with Acute hemorrhagic leukoencephalitis itself.
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Supercharged donor cells take on viruses after transplant
Disease control Recruiting nowThis study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…
Phase 1/2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Can donor cells stop viruses after transplant?
Disease control Recruiting nowThis study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…
Phase 2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Could immune checkpoint drugs tame a deadly brain virus?
Disease control Recruiting nowThis study is testing whether immune checkpoint inhibitors, drugs that help the immune system fight infections, can improve outcomes for people with progressive multifocal leukoencephalopathy (PML), a rare brain virus. Researchers will follow 66 patients over a year, measuring di…
Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Rapid brain infection test could slash unnecessary antibiotic use
Diagnosis Recruiting nowThis study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …
Sponsor: Federal University of Health Science of Porto Alegre • Aim: Diagnosis
Last updated Aug 23, 2026 00:00 UTC