Hope for rare brain disease: new drug trial targets autoimmune encephalitis

NCT ID NCT05503264

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 38 times

Summary

This Phase 3 trial tests satralizumab, a drug that calms the immune system, in 120 people with two types of autoimmune encephalitis (NMDAR or LGI1). The goal is to see if it improves disability and reduces the need for emergency treatments. Participants receive injections every 4 weeks for up to a year, with a follow-up period to check safety and long-term effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A. O. U. Federico II
RECRUITING

Naples, Campania, 80131, Italy
AOU Policlinico Giaccone
RECRUITING

Palermo, Sicily, 90129, Italy
AOU Seconda Università degli Studi
RECRUITING

Naples, Campania, 80138, Italy
Affiliated Hospital of Jining Medical University
RECRUITING

Jining, 272029, China
Ageo Central General Hospital
RECRUITING

Saitama, 362-8588, Japan
Beijing Children's Hospital, Capital Medical University
RECRUITING

Beijing, 100045, China
Beijing Tiantan Hospital,Capital Medical University
RECRUITING

Beijing, China
Beijing Tongren Hospital
RECRUITING

Beijing, 100730, China
Brigham and Women's Hospital Department of Neurology
RECRUITING

Boston, Massachusetts, 02115, United States
CEDOES - Diagnóstico e Pesquisa
RECRUITING

Vitória, Espírito Santo, 29055-450, Brazil
CHRU - Hôpital Bretonneau
RECRUITING

Tours, 37000, France
CHU Saint Etienne - Hôpital Nord
WITHDRAWN

Saint-Etienne, 42055, France
Centro de Pesquisas Clinicas
RECRUITING

São Paulo, São Paulo, 01228-200, Brazil
Chang Gung Memorial Hospital - Linkou
RECRUITING

Taoyuan City, 333, Taiwan
Chiba University Hospital
ACTIVE_NOT_RECRUITING

Chiba, 260-8677, Japan
Children's Healthcare of Atlanta Center for Advanced Pediatrics
RECRUITING

Atlanta, Georgia, 30329, United States
Childrens National Health Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
China Medical University Hospital
WITHDRAWN

North Dist., 40402, Taiwan
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44915, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fakultni nemocnice Hradec Kralove
WITHDRAWN

Hradec Králové, 500 05, Czechia
Fakultni nemocnice v Motole
RECRUITING

Prague, 150 06, Czechia
Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, Lombardy, 20133, Italy
Fondazione Istituto Neurologico Mondino IRCCS
RECRUITING

Pavia, Lombardy, 27100, Italy
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, 350001, China
Fujita Health University Hospital
RECRUITING

Aichi, 470-1192, Japan
Fukuoka University Hospital
RECRUITING

Fukuoka, 814-0180, Japan
Gifu University Hospital
RECRUITING

Gifu, 501-1194, Japan
Guangzhou First Municipal People's Hospital
WITHDRAWN

Guangzhou, 510180, China
Hadassah University Hospital Ein Kerem
RECRUITING

Jerusalem, 9112001, Israel
Hoag Memorial Hospital
COMPLETED

Newport Beach, California, 92658, United States
Hokkaido University Hospital
ACTIVE_NOT_RECRUITING

Hokkaido, 060-8648, Japan
Hopital Pitié Salpétrière - CHU
RECRUITING

Paris, 75651, France
Hopital neurologique Pierre Wertheimer - CHU Lyon
COMPLETED

Bron, 69677, France
Hospital Alvaro Cunqueiro
RECRUITING

Vigo, Pontevedra, DUMMY_VALUE, Spain
Hospital Britanico
RECRUITING

Ciudad Autonoma Bs As, C1280AEB, Argentina
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Geral de Fortaleza
RECRUITING

Fortaleza, Ceará, 60175-295, Brazil
Hospital Israelita Albert Einstein
RECRUITING

São Paulo, São Paulo, 05652-000, Brazil
Hospital Ramos Mejía
ACTIVE_NOT_RECRUITING

CABA, C1221ADC, Argentina
Hospital Regional Universitario de Malaga ? Hospital General
RECRUITING

Málaga, 29010, Spain
Huashan Hospital, Fudan University
RECRUITING

Shanghai, 200040, China
Hyogo prefectural Kobe Children's Hospital
RECRUITING

Hyogoken, 6500047, Japan
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Instituto de Neurologia de Curitiba
RECRUITING

Curitiba, Paraná, 81210-310, Brazil
Instytut Psychiatrii i Neurologii II Klinika Neurologiczna
RECRUITING

Warsaw, 02-957, Poland
Irccs A.O.U.San Martino Ist
RECRUITING

Genoa, Liguria, 16132, Italy
Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21205, United States
Juntendo University Hospital
RECRUITING

Tokyo, 113-8431, Japan
Kagoshima City Hospital
RECRUITING

Kagoshima, 890-8760, Japan
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 00833, Taiwan
Kepler Universitätsklinikum GmbH - Neuromed Campus
WITHDRAWN

Linz, 4020, Austria
Kindai University Hospital
RECRUITING

Osaka, 590-0197, Japan
Kitasato University Hospital
ACTIVE_NOT_RECRUITING

Kanagawa, 252-0375, Japan
Kobe University Hospital
RECRUITING

Hyōgo, 650-0017, Japan
Komfo Anokye Teaching Hospital
RECRUITING

Kumasi, Ghana
Kyushu University Hospital
COMPLETED

Fukuoka, 812-8582, Japan
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medizinische Universität Wien
WITHDRAWN

Vienna, 1090, Austria
NYU-Langone Medical Center
RECRUITING

New York, New York, 10016, United States
National Neuroscience Institute
RECRUITING

Singapore, 308433, Singapore
National University Hospital (NUH)
RECRUITING

Singapore, 117599, Singapore
Nihon University Itabashi Hospital
RECRUITING

Tokyo, 173-8610, Japan
Odense Universitetshospital, Neurologisk Afdeling N
RECRUITING

Odense C, 5000, Denmark
Ospedale Pediatrico Bambino Gesù
WITHDRAWN

Rome, Lazio, 00165, Italy
Regionalny Szpital Specjalistyczny im. W. Bieganskiego
WITHDRAWN

Grudzi?dz, 86-300, Poland
SPSK nr 1
RECRUITING

Zabrze, 41-800, Poland
Sanatorio del Sur S.A.
RECRUITING

San Miguel de Tucumán, T4000IDK, Argentina
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
St.Marianna University School of Medicine hospital
COMPLETED

Kanagawa, 216-8511, Japan
Swedish Neuroscience Institute
WITHDRAWN

Seattle, Washington, 98122, United States
Szpital Uniwersytecki w Krakowie
COMPLETED

Krakow, 30-688, Poland
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The First Affiliated Hospital of Wenzhou Medical University
COMPLETED

Wenzhou, 325035, China
The First Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The First Hospital of Shanxi Medical University
RECRUITING

Taiyuan, 030001, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, 410011, China
The University of Osaka Hospital
RECRUITING

Osaka, 565-0871, Japan
Tohoku University Hospital
RECRUITING

Miyagi, 980-8574, Japan
Tokai University Hospital
RECRUITING

Kanagawa, 259-1193, Japan
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
WITHDRAWN

Wuhan, 430030, China
UC San Diego
RECRUITING

La Jolla, California, 92037, United States
UCSF- Multiple Sclerosis Centre
RECRUITING

San Francisco, California, 94158, United States
Univ of Pennsylvania Med Ctr
WITHDRAWN

Philadelphia, Pennsylvania, 19104, United States
University Hospitals of Cleveland
RECRUITING

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospitals & Clinics
WITHDRAWN

Iowa City, Iowa, 52242, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Texas at Houston
RECRUITING

Houston, Texas, 77030, United States
West China Hospital - Sichuan University
RECRUITING

Chengdu, 610047, China

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

satralizumab (Enspryng)

What this could lead to

If successful, satralizumab could offer a new treatment option to control autoimmune encephalitis, reducing disability and the need for rescue therapies.

What could go wrong

This is an early Phase 3 trial with only 120 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects like infections are possible.

Conditions

The condition(s) this trial relates to.

anti-NMDA receptor encephalitis limbic encephalitis with LGI1 antibodies

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LGI1 AUTOIMMUNE ENCEPHALITIS NMDAR AUTOIMMUNE ENCEPHALITIS