Hip fracture

This phase 4 trial will test whether tranexamic acid (TXA), a drug that reduces bleeding, can safely lower blood loss in 200 orthopedic trauma patients who are on anticoagulants (blood thinners). Participants will have surgery for broken leg or thigh bones. The study compares tho…

This study looks at whether a single nerve block, given before surgery, can reduce the risk of heart muscle damage in older adults who have hip fracture surgery more than 48 hours after injury. Researchers will review medical records of 500 patients aged 65 and older, comparing t…

This study compares robot-assisted surgery to conventional surgery for treating unstable pelvic fractures (Tile B and C types). About 88 adults with recent fractures will be randomly assigned to one of the two procedures. Researchers will measure pain, function, recovery speed, a…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study will test a new, personalized smart home care model for older adults (60+) recovering from a hip fracture. The goal is to predict and improve recovery, reduce falls, and support caregivers. About 218 people from northern Taiwan will take part.

This study will compare aspirin tablets to daily injections of low molecular weight heparin (LMWH) for preventing dangerous blood clots in people who break their hip. Over 21,000 patients aged 60 and older across 96 UK hospitals will take part. Hospitals will switch between the t…

This study looks at whether using both a nail and a plate together can better fix certain complex hip fractures. The approach is meant to prevent the bone from collapsing and help people heal faster. Seventeen adults with these fractures will be followed for six months to check b…

This pilot study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks and blood clots in patients who had a hip fracture surgery and also suffered a heart injury. About 100 adults aged 45 and older will be randomly assigned to eith…

Older adults who break a hip and have surgery often develop postoperative delirium, a sudden state of confusion that can slow recovery. Researchers are testing whether adding a small dose of dexmedetomidine to standard spinal anesthesia reduces how often this confusion occurs. In…

Researchers are testing whether denosumab, a drug usually used for bone loss, can improve muscle strength and quality of life in older adults with sarcopenia after a hip fracture. The trial enrolls 130 people aged 65 and older who have low muscle mass and weakness. Participants r…

This trial tests whether a daily protein-rich nutritional drink, containing HMB, calcium, and vitamin D, can help older adults regain muscle strength after hip fracture surgery. Participants aged 65 and older will receive either the supplement or standard care for 30 days. Resear…

This trial tests whether giving a nerve block called a fascia iliaca compartment block (FICB) right after hospital admission, before hip fracture surgery, can improve recovery in patients aged 65 and older. Half of the 144 participants will receive the early block, while the othe…

This study tests whether a single injection of a slow-release painkiller (liposomal bupivacaine) into a nerve block can control pain for up to 72 hours after hip fracture surgery in older adults. The standard drug only lasts about 12 hours, often leading to more pain and opioid u…

This study tests whether using a virtual reality (VR) headset during hip replacement surgery can lower anxiety and prevent post-surgery confusion in older adults. Half of the participants will watch calming nature scenes through VR while under regional anesthesia, while the other…

This trial tests whether adding a specific nerve block (Quadro-Iliac Plane Block or Suprainguinal Fascia Iliaca Block) to standard pain management reduces the need for opioids after hip fracture surgery. About 90 adults having hip fracture surgery under spinal anesthesia will be …

This study tests whether giving iron supplements to older adults (75+) after hip fracture surgery can reduce fatigue and improve recovery. 528 participants will receive either intravenous iron, oral iron pills, or a placebo. The goal is to see if iron helps with energy, mobility,…

This study tests whether a device called TENS, which sends mild electrical pulses through the skin, can reduce pain and the need for painkillers in older adults with hip fractures. Thirty-two participants will receive either active TENS or a sham (fake) version for 45 minutes. Re…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study tests whether an AI-based smartphone app can improve recovery for 106 adults after hip or knee replacement or hip fracture surgery. Participants use the app for 12 weeks at home to get real-time feedback on their exercises, while a comparison group follows the same exe…

This study looks at whether abdominal massage and drinking warm water can prevent constipation and improve recovery in people who have had hip fracture surgery. About 81 adults will be randomly assigned to receive massage, warm water, or standard care. The goal is to see if these…

This study compares two spinal anesthesia methods for hip fracture surgery in people over 50. One method uses a single injection, the other uses a tiny tube to give the medicine in smaller doses. The goal is to see if the tube method causes fewer drops in blood pressure and relat…

This study looks at whether nutritional risk and muscle thickness can help predict recovery in adults aged 65 and older after hip fracture surgery. Researchers will measure nutritional status using a standard score and check muscle thickness in the thigh with a quick, painless ul…

This observational study aims to build and test models that predict risks like delirium and death after fracture surgery in older adults. Researchers will collect data on pain, sleep quality, and brain activity to see how these factors relate to short- and long-term outcomes. The…

This study watches 250 adults with broken leg or pelvis bones to see who develops hemorrhagic shock — a dangerous drop in blood pressure from blood loss. Researchers want to know which fractures are most likely to cause this emergency. The goal is to help doctors quickly spot and…

This study aims to create a guide that helps frail older adults with hip fractures choose treatments based on what matters most to them, such as walking ability or independence, rather than just survival. Researchers will review existing studies, analyze NHS data, and interview p…

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study looks at whether a special hospital program for older adults (65+) who need surgery can improve their outcomes. Researchers will compare patients treated before and after the program started, tracking deaths and complications within 28 days. About 150 participants will…

This study looks at 100 elderly patients with hip fractures to see if quick, easy tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors provide sa…