Heart valve disorder

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…

This study tests a new device called the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System for people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is placed through a catheter, avoiding open-hear…

This study is testing a new artificial heart valve, called the TRIFORMIS RESILIA, for people who need their tricuspid valve replaced. The tricuspid valve controls blood flow between two right heart chambers. Researchers will follow 75 adults who receive this valve during surgery …

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This study tests whether adding adenosine to the standard heart-protecting solution used during bypass surgery helps the heart recover better. Sixty adults having elective valve or bypass surgery will receive either adenosine or a placebo. Researchers will measure heart function,…

This study compares two blood thinners, apixaban and warfarin, in 120 adults with atrial fibrillation who recently had heart valve repair or replacement. The goal is to see if apixaban causes fewer major bleeding events while still preventing blood clots. Participants will be fol…

This registry will follow 500 adults who need surgical replacement of their aortic or mitral heart valve with a Dafodil bioprosthetic valve. The study collects real-world data on survival, valve function, and complications like blood clots or infection over 5 years. It aims to he…

This study tests a device called CA330 that filters blood during heart surgery to reduce severe bleeding. It includes 120 adults on blood thinners who need non-elective heart surgery. Participants are randomly assigned to receive either the filter plus standard care or standard c…

This study tests whether giving a single dose of intravenous iron the day after heart surgery can reduce the chance of long-term anemia. About 180 adults with low iron or anemia before surgery will be randomly assigned to receive either the iron treatment or a placebo. The main g…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

Researchers are testing a soft, wearable ultrasound patch that sticks to the chest and continuously images the heart in adults and children with severe heart conditions in intensive care. The study compares heart function measurements from the patch with results from standard bed…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study aims to see if a new method using electrical and mechanical signals from the heart can accurately diagnose valvular heart disease. Researchers will recruit 1,300 adults with and without valve problems to compare the new test against standard echocardiography. If it wor…

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study is testing a new digital stethoscope that listens for subtle changes in heart sounds to detect coronary artery disease and valve problems earlier. Researchers will record heart sounds from 500 adults who are already scheduled for heart scans or echocardiograms. The goa…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study tests whether closing the left atrial appendage (a small pouch in the heart) during valve surgery can prevent silent brain injuries in 100 adults without atrial fibrillation. Participants will have brain scans after surgery to check for hidden strokes. The goal is to f…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study tests whether foot massage or kinesio taping can help older adults (65+) move better and feel less afraid of movement after heart surgery. Sixty participants will receive one of the two treatments daily for a week. Researchers will measure mobility, pain, and fear of m…

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium affects up to 70% of older heart surgery patients and can lead to longer hospital stays and memory probl…

This study compares two types of heart valve surgery: a newer, less invasive method through a small cut on the right side of the chest versus the traditional method through a cut down the middle of the chest. Researchers will measure how quickly patients recover, including time o…

Researchers are running a national registry of hospitalized patients aged 60 and older who have moderate or severe heart valve disease. The study records the type of valve problem, symptoms, other conditions, treatments received, and complications. By comparing this group with pa…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study follows 75 older adults having elective heart surgery to understand why some recover quickly while others face complications like delirium or slow recovery. Researchers will measure frailty, physical and mental function, and a blood marker of biological stress called G…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This study will create a registry of about 120 patients in Poland who have carcinoid heart disease, a rare complication of neuroendocrine tumors that damages heart valves. Researchers will collect medical records, echocardiograms, and lab results to better understand who develops…

This pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms …

This study will compare how well heart and lung function recover after robot-assisted heart surgery versus traditional open-heart surgery. Researchers will measure exercise capacity and breathing in 80 patients before and after surgery. The goal is to see if the less invasive rob…