Gastroparesis

This trial tests whether adding a Braun anastomosis, an extra connection between two parts of the small intestine, during standard pancreatic surgery helps prevent delayed gastric emptying. Delayed gastric emptying is a common complication where the stomach is slow to empty food,…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This pilot trial tests whether a new non-invasive device called Gastric Alimetry, which records stomach muscle activity through skin electrodes, can guide treatment for people with suspected gastroparesis better than the standard gastric emptying scan. Researchers will compare ma…

This study tested a special capsule with a magnet inside that doctors can control from outside the body. The capsule takes pictures of the stomach to see how it moves and digests food. Researchers wanted to see if this device could help diagnose conditions like gastroparesis and …

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This early-stage trial tests a noninvasive device that uses magnetic pulses to stimulate nerves in the upper back. The goal is to reduce severe nausea, vomiting, and stomach pain in people with diabetic gastroparesis (stomach paralysis). About 48 adults with moderate-to-severe sy…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This pilot study tests whether a transcutaneous electrical nerve stimulation (TENS) device is acceptable and helpful for people with scleroderma who experience gastroparesis symptoms like bloating and distension. Participants use the device for 45 minutes twice daily after meals …

This study tests whether a chair-based yoga program is practical and acceptable for people with functional dyspepsia or gastroparesis—conditions that cause nausea, vomiting, and stomach pain. Ten adults will attend two one-hour yoga sessions and practice at home. Researchers will…

This study tested a wearable device that delivers mild electrical pulses through the skin, similar to acupuncture, to help relieve stomach symptoms in people with diabetic gastroparesis. 41 participants used the device at either a treatment point or a sham point for 84 days. Rese…

This Phase 2 trial tests whether CIN-102 (deudomperidone) can reduce nausea in adults with idiopathic gastroparesis, a condition where the stomach empties slowly. Over 400 participants will take either 10 mg, 15 mg, or a placebo twice daily for 12 weeks. Researchers will track sy…

This study tests whether a mild electrical pulse to the ear (taVNS) can change how the brain and stomach interact in people with chronic indigestion or gastroparesis. Researchers will use brain scans and stomach electrical readings to see if the stimulation helps. The goal is to …

This study tested whether cognitive behavioral therapy (CBT) can reduce symptoms of gastroparesis, a condition where the stomach empties slowly, causing nausea, bloating, and pain. Twenty-seven adults with idiopathic gastroparesis received CBT sessions and were assessed before an…

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study tested whether a device that sends small electrical pulses to the stomach can help children with severe, long-lasting nausea and vomiting. Thirty kids who hadn't gotten better with standard treatments took part. Each child had a temporary pacing lead placed through a t…

This study tested an experimental drug called CIN-102 (deudomperidone) to see if it can reduce nausea, vomiting, and other stomach symptoms in adults with diabetic gastroparesis—a condition where the stomach empties too slowly. About 382 participants took either the drug or a pla…

This study tests whether a non-invasive device called Gastric Alimetry can detect changes in stomach muscle activity caused by semaglutide (Ozempic). Researchers will measure stomach electrical signals and symptoms in people with and without diabetes before and after taking the w…

This study watches 186 adults who take GLP-1 drugs (like Ozempic) and are having planned surgery. Researchers use a stomach ultrasound to check how much food or liquid is left in the stomach after stopping the drug for different lengths of time. The goal is to see if longer pause…

This completed study looked at how meals with different amounts and types of fat and carbohydrates affect digestion and blood sugar/fat levels in 12 healthy adults. Participants ate test meals and had blood samples taken over 5 hours. The goal was to understand how meal compositi…

This study looked at why many critically ill children develop gut problems like slow digestion and leaky gut. Researchers measured certain proteins linked to inflammation in 99 children to see if they cause these issues. The goal was to better understand the problem, not to test …

This study looked at 18 women who had sleeve gastrectomy surgery 2-3 years earlier. Researchers compared stomach emptying rates between those who lost a lot of weight (over 35% of total weight) and those who lost little (under 25%). They used MRI and a special scan to measure how…

This study looked at whether giving a carbohydrate drink (yogurt with honey) before elective abdominal surgery is safe and helpful for people with type 2 diabetes. 120 patients were split into three groups: non-diabetic controls, non-diabetic with the drink, and diabetic with the…

This study looked at 186 adults taking GLP-1 RA drugs (like Ozempic) who were scheduled for surgery. Researchers used ultrasound to measure stomach contents at different times after the last dose. The goal was to find out how long it takes for stomach emptying to return to normal…

This study looked at whether GLP-1 medications (used for diabetes and weight loss) increase the risk of having food or liquid in the stomach before surgery, even after the recommended fasting period. Researchers used a quick ultrasound to check stomach contents in 94 adults sched…

This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medic…

This study looked at whether giving a carbohydrate drink 2 hours before surgery is safe for people with well-controlled type 2 diabetes. 76 adults were split into two groups: one got the drink, the other fasted as usual. Researchers measured blood sugar and checked stomach conten…

This study tested whether dexmedetomidine, a sedative often used during surgery, changes how quickly the stomach empties in people having their gallbladder removed. Researchers used ultrasound to measure stomach volume in 80 patients before and after surgery. The goal was to see …

This study tested how two types of soluble fiber—fructooligosaccharide and partially hydrolyzed guar gum—affect how fast food leaves the stomach and moves through the intestines. Twenty-five healthy adults each tried both fibers and a placebo on separate days. The goal was to see…

This study used bedside ultrasound to see if people taking semaglutide (Ozempic, Wegovy) have more food or liquid in their stomachs before surgery, despite fasting. Researchers compared 88 adults on semaglutide to those not taking it. The goal was to help anesthesiologists decide…