Digestive system disorder
MONDO:0004335A disease or disorder that involves the digestive system.
Also known as: digestive disease, digestive system disease, digestive system disease or disorder, digestive system disorder, disease of digestive system, disease or disorder of digestive system, disorder of digestive system, gastroenterological system disease
16300 clinical trials for this condition and its sub-types, 168 tagged with Digestive system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system disorder
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Digestive system cancer 267 trials · 7,054 incl. sub-types
15 sub-types
- Digestive system carcinoma 25 trials · 4,876 incl. sub-types Sub-types →
- Intestinal cancer 25 trials · 2,786 incl. sub-types Sub-types →
- Liver cancer 254 trials · 1,700 incl. sub-types Sub-types →
- Malignant pancreatic neoplasm 899 trials · 1,444 incl. sub-types Sub-types →
- Gastric cancer 724 trials · 1,034 incl. sub-types Sub-types →
- Esophageal cancer 408 trials · 787 incl. sub-types Sub-types →
- Pharynx cancer 10 trials · 495 incl. sub-types Sub-types →
- Oral cavity cancer 42 trials · 288 incl. sub-types Sub-types →
- Gastroesophageal cancer 157 trials
- Gallbladder cancer 73 trials · 106 incl. sub-types Sub-types →
- Gastrointestinal lymphoma 0 trials · 7 incl. sub-types Sub-types →
- Jaw cancer 1 trial · 5 incl. sub-types Sub-types →
- Digestive system melanoma 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Spleen cancer 0 trials · 2 incl. sub-types Sub-types →
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Pancreas disorder 44 trials · 5,580 incl. sub-types
14 sub-types
- Endocrine pancreas disorder 1 trial · 3,923 incl. sub-types Sub-types →
- Pancreatic neoplasm 926 trials · 1,573 incl. sub-types Sub-types →
- Pancreatitis 120 trials · 203 incl. sub-types Sub-types →
- Exocrine pancreatic insufficiency 29 trials Sub-types →
- Recurrent acute pancreatitis 19 trials
- Accessory pancreas 0 trials
- Acinar cystic transformation of the pancreas 0 trials
- Annular pancreas 0 trials
- Congenital pancreatic cyst 0 trials
- Follicular cholangitis and pancreatitis 0 trials
- Lymphoepithelial cyst of the pancreas 0 trials
- Pancreatic mucinous ductal ectasia 0 trials
- Pancreatic steatorrhea 0 trials
- Pancreatic triacylglycerol lipase deficiency 0 trials Sub-types →
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Intestinal disorder 70 trials · 5,432 incl. sub-types
58 sub-types
- Large intestine disorder 2 trials · 3,811 incl. sub-types Sub-types →
- Intestinal neoplasm 4 trials · 3,074 incl. sub-types Sub-types →
- Inflammatory bowel disease 429 trials · 1,079 incl. sub-types Sub-types →
- Gastroenteritis 20 trials · 837 incl. sub-types Sub-types →
- Small intestine disorder 7 trials · 385 incl. sub-types Sub-types →
- Irritable bowel syndrome 221 trials
- Bowel dysfunction 11 trials · 210 incl. sub-types Sub-types →
- Glucose-galactose malabsorption 2 trials · 151 incl. sub-types Sub-types →
- Malabsorption syndrome 13 trials · 118 incl. sub-types Sub-types →
- Intestinal obstruction 44 trials · 91 incl. sub-types Sub-types →
- Eosinophilic gastrointestinal disease 9 trials · 73 incl. sub-types Sub-types →
- Intestinal fistula 6 trials · 63 incl. sub-types Sub-types →
- Necrotizing enterocolitis 51 trials Sub-types →
- Intestinal motility disease 10 trials · 39 incl. sub-types Sub-types →
- Short bowel syndrome 39 trials Sub-types →
- Diverticulitis 28 trials · 34 incl. sub-types Sub-types →
- Chronic intestinal failure 24 trials
- Neurogenic bowel 22 trials
- Postgastrectomy syndrome 2 trials · 20 incl. sub-types Sub-types →
- Hypertrophic pyloric stenosis 16 trials Sub-types →
- Parasitic intestinal disorder 0 trials · 16 incl. sub-types Sub-types →
- Ischemic bowel disorder 8 trials · 15 incl. sub-types Sub-types →
- Endometriosis of intestine 9 trials
- Intestinal perforation 9 trials Sub-types →
- Intestinal polyp 8 trials
- Protein-losing enteropathy 7 trials
- Intestinal atresia 3 trials · 6 incl. sub-types Sub-types →
- Chronic intestinal vascular insufficiency 4 trials
- Refractory celiac disease 4 trials
- Volvulus of midgut 4 trials Sub-types →
- Abetalipoproteinemia 2 trials
- Pneumatosis cystoides intestinalis 2 trials
- Angiodysplasia of intestine 1 trial
- Chronic enteropathy associated with SLCO2A1 gene 1 trial
- Cryptogenic multifocal ulcerous stenosing enteritis 1 trial
- Steatorrhea 1 trial Sub-types →
- 4-hydroxyphenylacetic aciduria 0 trials
- Aeromonas hydrophila intestinal disease 0 trials
- NK-cell enteropathy 0 trials
- Satoyoshi syndrome 0 trials
- Whipple disease 0 trials
- Aplasia cutis congenita-intestinal lymphangiectasia syndrome 0 trials
- Chronic atrial and intestinal dysrhythmia 0 trials
- Chronic diarrhea with villous atrophy 0 trials
- Collagenous sprue 0 trials
- Congenital diarrhea 7 with exudative enteropathy 0 trials
- Congenital enterocyte heparan sulfate deficiency 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Intestinal dysmotility syndrome 0 trials
- Intestinal lymphangiectasia 0 trials Sub-types →
- Intractable diarrhea-choanal atresia-eye anomalies syndrome 0 trials
- Isolated mesenteric vein thrombosis 0 trials
- Malakoplakia 0 trials
- Mucocele of appendix 0 trials
- Primary desmosis coli 0 trials
- Solitary rectal ulcer syndrome 0 trials
- Trichohepatoenteric syndrome 0 trials Sub-types →
- Visceral leiomyopathy, African degenerative 0 trials
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Hepatobiliary disorder 10 trials · 3,893 incl. sub-types
4 sub-types
- Liver disorder 323 trials · 3,604 incl. sub-types Sub-types →
- Hepatobiliary neoplasm 26 trials · 1,772 incl. sub-types Sub-types →
- Biliary tract disorder 22 trials · 1,001 incl. sub-types Sub-types →
- Gallbladder disorder 26 trials · 219 incl. sub-types Sub-types →
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Stomach disorder 4 trials · 1,623 incl. sub-types
19 sub-types
- Gastric neoplasm 685 trials · 1,101 incl. sub-types Sub-types →
- Gastroesophageal reflux disease 217 trials Sub-types →
- Functional gastric disease 47 trials · 213 incl. sub-types Sub-types →
- Gastritis 21 trials · 50 incl. sub-types Sub-types →
- Hiatus hernia 49 trials Sub-types →
- Pyloric stenosis 15 trials · 31 incl. sub-types Sub-types →
- Gastric intestinal metaplasia 18 trials
- Gastric ulcer 13 trials Sub-types →
- Stomach polyp 4 trials · 6 incl. sub-types Sub-types →
- Gastric dilatation 3 trials
- Achlorhydria 1 trial
- Pylorospasm 1 trial
- Dieulafoy lesion 0 trials
- Angiodysplasia of stomach 0 trials
- Cascade stomach 0 trials
- Gastric duplication 0 trials
- Non-hypoproteinemic hypertrophic gastropathy 0 trials
- Pyloric duplication 0 trials
- Stomach diverticulosis 0 trials
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Upper digestive tract disorder 6 trials · 1,226 incl. sub-types
2 sub-types
- Esophageal disorder 20 trials · 1,221 incl. sub-types Sub-types →
- Internal hirudiniasis 0 trials
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Autoimmune disorder of gastrointestinal tract 0 trials · 936 incl. sub-types
7 sub-types
- Type 1 diabetes mellitus 815 trials · 816 incl. sub-types Sub-types →
- Celiac disease 79 trials Sub-types →
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Autoimmune enteropathy 2 trials · 11 incl. sub-types Sub-types →
- Autoimmune gastritis 3 trials
- Autoimmune pancreatitis 3 trials Sub-types →
- IgG4-related sclerosing cholangitis 0 trials
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Digestive system infectious disorder 4 trials · 605 incl. sub-types
22 sub-types
- Viral hepatitis 12 trials · 443 incl. sub-types Sub-types →
- Infectious colitis 0 trials · 69 incl. sub-types Sub-types →
- Intestinal infectious disease 3 trials · 49 incl. sub-types Sub-types →
- Small intestinal bacterial overgrowth 18 trials
- Parasitic intestinal disorder 0 trials · 16 incl. sub-types Sub-types →
- Liver abscess (disease) 4 trials
- Campylobacteriosis 3 trials Sub-types →
- Bacterial gastritis 2 trials
- Gastrointestinal tuberculosis 0 trials · 2 incl. sub-types Sub-types →
- Aeromonas hydrophila intestinal disease 0 trials
- Salmonella gastroenteritis 0 trials
- Whipple disease 0 trials
- Anal verrucous carcinoma 0 trials
- Bacterial esophagitis 0 trials
- Colorectal Kaposi sarcoma 0 trials Sub-types →
- Fungal esophagitis 0 trials Sub-types →
- Fungal gastritis 0 trials
- Internal hirudiniasis 0 trials
- Oropharyngeal anthrax 0 trials
- Polycystic echinococcosis 0 trials
- Viral esophagitis 0 trials
- Viral gastritis 0 trials Sub-types →
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Neoplasm of oropharynx 3 trials · 279 incl. sub-types
2 sub-types
- Oropharynx cancer 149 trials · 279 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
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Digestive system neuroendocrine neoplasm 52 trials · 167 incl. sub-types
7 sub-types
- Digestive system neuroendocrine tumor, grade 1/2 66 trials · 145 incl. sub-types Sub-types →
- Pancreatic neuroendocrine neoplasm 9 trials · 85 incl. sub-types Sub-types →
- Intestinal neuroendocrine neoplasm 7 trials · 21 incl. sub-types Sub-types →
- Gastric neuroendocrine neoplasm 3 trials · 6 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Gallbladder neuroendocrine neoplasm 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Diarrheal disease 80 trials · 117 incl. sub-types
7 sub-types
- Acute diarrhea 10 trials · 42 incl. sub-types Sub-types →
- Inflammatory diarrhea 0 trials · 33 incl. sub-types Sub-types →
- Chronic diarrheal disease 10 trials Sub-types →
- Congenital diarrhea 0 trials · 5 incl. sub-types Sub-types →
- Secretory diarrhea 0 trials · 5 incl. sub-types Sub-types →
- Diarrheal disease secondary to altered bowel motility 0 trials Sub-types →
- Non-infectious diarrheal disease 0 trials Sub-types →
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Peptic ulcer disease 26 trials · 67 incl. sub-types
6 sub-types
- Peptic esophagitis 24 trials
- Gastric ulcer 13 trials Sub-types →
- Duodenal ulcer 7 trials
- Gastrojejunal ulcer 6 trials
- Active peptic ulcer disease 3 trials
- Peptic ulcer perforation 3 trials
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Gastrointestinal mucositis 3 trials · 52 incl. sub-types
2 sub-types
- Intestinal infectious disease 3 trials · 49 incl. sub-types Sub-types →
- Inflammatory diarrhea 0 trials · 33 incl. sub-types Sub-types →
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Benign digestive system neoplasm 0 trials · 41 incl. sub-types
10 sub-types
- Pleomorphic adenoma 12 trials
- Hepatobiliary benign neoplasm 2 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of pancreas 7 trials Sub-types →
- Intestinal benign neoplasm 1 trial · 7 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Benign neoplasm of stomach 1 trial · 2 incl. sub-types Sub-types →
- Hepatocellular adenoma 2 trials Sub-types →
- Benign neoplasm of gallbladder 0 trials Sub-types →
- Benign neoplasm of oropharynx 0 trials
- Bile duct papillary neoplasm 0 trials Sub-types →
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Hereditary mixed polyposis syndrome 5 trials · 6 incl. sub-types
2 sub-types
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Juvenile polyposis syndrome 5 trials
3 sub-types
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Gastrointestinal polyp 0 trials · 3 incl. sub-types
2 sub-types
- Gastrointestinal hamartoma 0 trials · 3 incl. sub-types Sub-types →
- Anal polyp 0 trials Sub-types →
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Cronkhite-Canada syndrome 1 trial
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Hyperplastic polyposis syndrome 1 trial
2 sub-types
- Colon serrated polyposis 1 trial
- Sessile serrated polyposis cancer syndrome 0 trials
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Meckel diverticulum 0 trials
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Caudal duplication 0 trials
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Common mesentery 0 trials
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Congenital peritoneal encapsulation 0 trials
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Digestive duplication 0 trials
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Diverticulosis, small-intestinal 0 trials
Most studied deeper sub-types
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Could vitamin c help protect the gut in transplant patients?
Disease control Not yet recruitingThis early-phase trial tests whether adding vitamin C to standard steroid treatment helps people with gastrointestinal graft-versus-host disease (GVHD), a serious complication after a donor stem cell transplant. About 35 participants aged 5 and older will receive vitamin C plus s…
Early phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Can a probiotic keep ulcerative colitis in check?
Disease control Not yet recruitingThis trial is testing whether a probiotic supplement called Colipral, which contains a specific strain of E. coli bacteria, can improve gut health in people with ulcerative colitis who are in remission but still have digestive issues. Participants will take either the supplement …
Sponsor: University of Padova • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Can a new biologic calm the immune attack in ulcerative colitis?
Disease control Not yet recruitingThis early-stage trial is testing whether a drug called aletekitug is safe and tolerable for people with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The drug works by blocking a protein called IL-18, which may play a role in the inflammation that …
Phase 1 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Can a new biologic tame ulcerative colitis?
Disease control Not yet recruitingThis early trial is testing an experimental biologic drug called aletekitug in adults with moderate to severe ulcerative colitis. The main goal is to see if the drug is safe and tolerable when given repeatedly. Researchers will monitor side effects and changes in lab tests, vital…
Phase 1 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Gut check: can five friendly bacteria restore digestive balance?
Disease control Not yet recruitingThis trial is testing whether a probiotic supplement containing five naturally occurring gut bacteria can improve the balance of microbes in the digestive tract and reduce symptoms like bloating, pain, and irregularity. Adults with at least moderate gastrointestinal distress will…
Sponsor: OvationLab • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Ancient herbal mix targets dual gut disorders in one shot
Disease control Not yet recruitingThis study tests whether a traditional Chinese herbal formula called Hewei Anchang Formula can ease overlapping symptoms of functional dyspepsia (indigestion) and diarrhea-predominant irritable bowel syndrome (IBS-D). Researchers will give 120 adults either the herbal granules or…
Sponsor: Xiyuan Hospital of China Academy of Chinese Medical Sciences • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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Could a stomach shield drug replace acid blockers for steroid users?
Disease control Not yet recruitingThis study tests whether teprenone, a stomach-protecting drug, can reduce gastrointestinal damage caused by high-dose steroids in people with lupus. One hundred participants will be randomly assigned to take either teprenone or the standard acid-blocker omeprazole for 12 weeks. T…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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A simple stool test might replace scopes for kids with gut issues
Diagnosis Not yet recruitingResearchers at Assiut University are testing whether a stool test for calprotectin, a protein linked to inflammation, can accurately detect gut inflammation in children with chronic digestive symptoms. The study will compare stool test results with findings from endoscopy and tis…
Sponsor: Assiut University • Aim: Diagnosis
Last updated Sep 10, 2026 00:00 UTC
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Could a simple ultrasound spot hidden depression in gut patients?
Diagnosis Not yet recruitingThis study explores whether routine blood vessel tests can help identify depression in people with chronic atrophic gastritis, a stomach condition. Many patients with this disease have undiagnosed depression due to stigma. Researchers will use ultrasound and other vascular measur…
Sponsor: China Academy of Chinese Medical Sciences • Aim: Diagnosis
Last updated Jun 27, 2026 08:09 UTC
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Can a $50 water filter keep appalachian families out of the bathroom?
Prevention Not yet recruitingMany homes in rural Central Appalachia rely on private wells and springs rather than treated utility water. Researchers are testing whether giving households a multi-stage point-of-use water filter reduces acute gastrointestinal illness and waterborne infections. The trial enroll…
Sponsor: Virginia Polytechnic Institute and State University • Aim: Prevention
Last updated Sep 16, 2026 00:00 UTC
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Could a common numbing drug cut Post-Surgery opioid use?
Symptom relief Not yet recruitingThis study tests whether giving lidocaine through an IV, along with a spinal morphine injection, can lower the amount of morphine patients need after major digestive or abdominal surgery. About 76 adults having planned open abdominal surgery will be randomly assigned to receive e…
Phase 3 • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Aug 27, 2026 00:00 UTC
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Could goat milk formula soothe fussy Babies' tummies?
Symptom relief Not yet recruitingThis trial is testing whether goat milk formula can ease gastrointestinal discomfort in infants aged 0 to 5 months. Babies with symptoms like bloating, excessive crying, or spitting up will be randomly assigned to receive either goat milk or standard cow milk formula. The study w…
Sponsor: Ruijin Hospital • Aim: Symptom relief
Last updated Aug 23, 2026 00:00 UTC
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Can a VR headset calm nerves before a scope?
Symptom relief Not yet recruitingThis trial tests whether using virtual reality (VR) before an upper gastrointestinal endoscopy can reduce patient anxiety, improve psychological readiness, and boost satisfaction after the procedure. About 52 adults scheduled for the procedure will be randomly assigned to either …
Sponsor: Ardahan University • Aim: Symptom relief
Last updated Aug 06, 2026 00:00 UTC
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Could a daily synbiotic capsule ease emotional and gut symptoms in ADHD?
Symptom relief Not yet recruitingThis study investigates whether a synbiotic supplement—a mix of probiotics and prebiotics—can improve emotion regulation and reduce gastrointestinal problems in adults with ADHD. Participants take either the synbiotic or a placebo capsule daily for 12 weeks. The main focus is on …
Sponsor: Super Synbiotics AB • Aim: Symptom relief
Last updated Jul 23, 2026 00:00 UTC
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Smartphone app aims to uncover food triggers for gut cancer survivors
Symptom relief Not yet recruitingThis study tests a mobile app called GutCheck for people who have survived gastrointestinal cancer. Participants track their diet, stress, and gut symptoms daily. The app analyzes the data to identify potential trigger foods. The goal is to see if the app is feasible and helpful …
Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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Could an online Brain-Gut therapy ease chronic stomach pain?
Symptom relief Not yet recruitingThis study tests whether an internet-based cognitive behavioral therapy (iCBT) program is feasible and helpful for adults with functional gastrointestinal disorders (FGID), like irritable bowel syndrome (IBS). Thirty participants will complete a 10-week online program with therap…
Sponsor: University of Aarhus • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Could a probiotic ease tummy troubles in seniors?
Symptom relief Not yet recruitingThis study is testing a special probiotic supplement in 30 adults aged 50-65 who have ongoing bowel issues like constipation, irritable bowel syndrome, or stomach pain. The goal is to see if the probiotic can improve gut immunity, balance gut bacteria, and ease symptoms like bloa…
Sponsor: Maanshan Shiqiye Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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Can a gummy beat bloating? new study puts supplement to the test
Symptom relief Not yet recruitingThis study will test whether a dietary supplement called Bloat Gummies can reduce bloating, gas, and abdominal discomfort after meals. One hundred healthy adults who often feel bloated will take either the active gummies or a placebo after two test meals, then report their sympto…
Sponsor: Arrae • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Hospital talk therapy: extra rounds may calm nerves before endoscopy
Symptom relief Not yet recruitingThis study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…
Sponsor: LanZhou University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Gut feeling could save lives: new score may improve ICU death predictions
Knowledge-focused Not yet recruitingThis study looks at whether adding a measure of gut function to a standard organ failure score can better predict which critically ill patients are at highest risk of dying. Researchers will follow 800 adults in Turkish ICUs, using only routine data—no extra tests or treatments. …
Sponsor: Ozkul Yilmaz Colak • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Massive saudi study aims to improve emergency surgery survival
Knowledge-focused Not yet recruitingThis study will collect data from 10,000 patients across Saudi Arabia who undergo emergency abdominal surgery (laparotomy). Researchers will track complications and deaths within 30 and 90 days after surgery. The goal is to understand current care quality, test international risk…
Sponsor: King Faisal Specialist Hospital & Research Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Screening for celiac disease: could early diagnosis improve lives?
Knowledge-focused Not yet recruitingThis study follows 250 adults in Finland who were previously screened for celiac disease to see how early diagnosis affects their long-term health, diet habits, and quality of life. Researchers will track symptoms, gluten-free diet adherence, and overall well-being. The goal is t…
Sponsor: Tampere University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Should ICU tube feed be watered down? new study aims to find out
Knowledge-focused Not yet recruitingThis study will compare diluted and undiluted tube feeding in 80 critically ill adults after major abdominal surgery. Half will get extra fluids mixed with their feed, the other half will get undiluted feed with fluids given separately through an IV. The goal is to see which appr…
Sponsor: John Paul II Catholic University of Lublin • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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New study to track hidden salt and mineral imbalances in sick kids
Knowledge-focused Not yet recruitingThis study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:41 UTC