Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a common numbing drug cut Post-Surgery opioid use?

NCT ID NCT07076641

Symptom relief Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 4 times

Summary

This study tests whether giving lidocaine through an IV, along with a spinal morphine injection, can lower the amount of morphine patients need after major digestive or abdominal surgery. About 76 adults having planned open abdominal surgery will be randomly assigned to receive either lidocaine or a placebo. The goal is to see if lidocaine helps control pain better and reduces morphine use in the first 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine (intravenous)
What this could lead to
If it works, this could offer a way to reduce morphine use after major abdominal surgery, potentially lowering side effects like nausea or drowsiness.
What could go wrong
This is a small, early-stage trial with only 76 participants, so results may not apply to everyone. Lidocaine can cause side effects like dizziness or heart issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 76 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years; * Major digestive or abdominal surgery (pancreatic, hepatic, colorectal, gynecological, esophageal, gastric, duodenal, small intestine...); * Scheduled surgery; * Laparotomy; * Patient in agreement with morphine rachi anesthesia; * Social security affiliation; * Signed informed consent. Exclusion Criteria: * Emergency surgery; * Contraindication to non-steroidal anti-inflammatory drugs: history of gastro duodenal ulcer, renal failure from stage 3 A or higher; * History of bradycardia and/or known conduction disorder (atrioventricular block) / Pacemaker ; * Unstable coronary ; * Myocardial infarction \<6 months; * Severe cardiocirculatory insufficiency; * Severe hepatic insufficiency; * Allergy to morphine ; * Allergy to lidocaine; * Rhythm disorders at risk of sudden death (e.g. Brugada syndrome); * Flecaine as usual treatment; * Chronic pain with level II or III analgesics; * Gabapentinoids: pregabalin (Lyrica), gabapentin; * Drug addiction and substitute drugs; * Epileptic disorders ; * Myasthenia gravis; * Creatinine clearance below 10 mL/min; * Hypokalemia, hypoxia or acid-base disorders; * Patient participating in another clinical trial, or in a period of exclusion from another clinical trial; * Inability to understand study information (due to linguistic, psychological, cognitive or literacy problems); * Women who are or may become pregnant\* (of childbearing age, without effective contraception) or who are breast-feeding; * Patient deprived of liberty, under guardianship or unable to give consent.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Digestive system disease are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Digestive System Diseases digestive system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Digestive system disease Surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Privé Jean Mermoz

    Lyon, 69008, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.