Diastolic heart failure

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This trial tests whether a digital tool that prompts doctors to adjust heart failure medications can improve care. The tool uses home monitoring and patient data to suggest medication changes. The study includes over 1,300 adults with heart failure and will measure hospitalizatio…

This study tests a small device, called the Coronary Sinus Reducer, in 35 people with a type of heart failure where the heart pumps well but still has trouble filling with blood. The device is placed in a vein of the heart to help lower pressure during exercise. The goal is to se…

This study tests a modified pacemaker designed to improve heart function and quality of life in people with heart failure with preserved ejection fraction (HFpEF). About 105 participants will receive either the active pacing therapy or a non-pacing mode. Researchers will measure …

This study tests an experimental drug (BMS-986435/MYK-224) in people with a specific type of heart failure where the heart pumps normally but is too stiff (HFpEF). The main goal is to check the drug's safety and how the body processes it. About 208 adults with stable symptoms wil…

This study looks at the long-term safety of a drug called sotatercept for people with a specific type of pulmonary hypertension caused by heart failure with preserved ejection fraction. About 130 people who completed a prior study will receive sotatercept injections and be monito…

This study investigates whether a specific leg exercise program can improve how blood vessels, muscles, and nerves work during exercise in people over 65 with heart failure with preserved ejection fraction (HFpEF). The trial focuses on peripheral problems—like reduced blood flow …

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This was a planned Phase 2 study testing a drug called CDR132L in about 130 people with heart failure and a preserved or mildly reduced ejection fraction. The drug aimed to reverse harmful changes in the heart muscle. However, the trial was withdrawn before any participants were …

This study tests an experimental drug called TX000045 in 180 adults with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure where the heart pumps normally but doesn't relax properly. Participants will receive either the drug or a placebo f…

This study tests whether hearts from donors who died from circulatory death (DCD) are as safe for transplant as hearts from brain-dead donors (DBD). About 40 adult heart transplant recipients will receive either a DCD or DBD heart. The goal is to see if using DCD hearts can safel…

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart fu…

This study tests a device called the Edwards APTURE shunt, which is implanted in the heart to create a small opening that lowers pressure. The goal is to see if it can improve symptoms and quality of life for 100 people with a certain type of heart failure. Half of the participan…

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…

This study looks at whether doing a preventive heart ablation (a procedure to destroy small areas of heart tissue causing irregular rhythms) before LVAD surgery can reduce serious problems like dangerous heart rhythms, death, blood clots, or heart failure in the first 30 days aft…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests a small device called the Corvia Atrial Shunt in 750 people with heart failure where the heart pumps normally but doesn't fill properly. The device creates a tiny passage between heart chambers to relieve pressure. Participants are randomly assigned to get the sh…

This study tests whether a drug called finerenone can reduce scarring and fat buildup in the heart muscle of people with diabetic kidney disease and heart failure. About 40 adults will take the pill daily for 6 months and get advanced heart scans to see if their heart structure i…

This study tests a dual GIP/GLP-1 drug (a type of diabetes medication) in 120 adults in Kazakhstan who have both chronic heart failure and type 2 diabetes. Participants take the drug for 40 weeks and have regular heart tests, blood work, and genetic checks. The goal is to see if …

This study tests whether enavogliflozin, a diabetes drug, can improve outcomes in people with heart failure and a leaky tricuspid valve. About 541 participants will receive either the drug or a placebo for 18 months. Researchers will track heart-related events, valve worsening, a…

This Phase 2 study tests an injectable drug called HRS9531 in 203 obese adults with a type of heart failure where the heart pumps normally but is stiff. Participants receive either the drug or a placebo for 52 weeks. The main goals are to see if the drug helps with weight loss an…

This registry follows 350 adult heart transplant patients whose donor hearts were kept alive and beating using the OCS Heart System before transplant. The goal is to see how well patients do one year after surgery. The device may allow more donor hearts to be used, especially tho…

Researchers are testing whether an artificial intelligence system can analyze echocardiogram images and draft reports as accurately as experienced sonographers in patients with heart failure. The trial enrolls adults with new or worsening heart failure symptoms and elevated heart…

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This study looks at whether existing blood markers can accurately identify the underlying cause of heart failure in 511 patients. Researchers aim to improve diagnosis and potentially reduce healthcare costs by avoiding unnecessary tests. Participants were recently diagnosed with …

This study looks at better ways to diagnose a type of heart failure called HFpEF in people who have unexplained shortness of breath. Researchers will compare non-invasive tests to the standard invasive method in 30 adults aged 18-90. The goal is to make diagnosis easier and more …

Researchers are testing whether Azerbaijani national dance sessions can improve cardiorespiratory fitness and quality of life in older adults with chronic heart failure. The trial enrolls 120 people aged 65 to 85 whose heart failure is confirmed by an ejection fraction between 40…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, exercise ability, and quality of life in 150 adults with a type of heart failure called HFpEF who also have iron deficiency. Participants will receive either the iron infusion …

This study tests a program called CHAT for people aged 60 and older with a type of heart failure called HFpEF. Participants get up to four sessions with a health coach and watch seven educational videos, all from home. The goal is to see if this helps them manage their condition …

This study looks at whether gradually stopping beta-blockers (medicines often used for heart failure) can improve symptoms and daily function in adults aged 60 and older with a specific type of heart failure called HFpEF. About 240 participants will either taper off their beta-bl…

This study tests a personalized, remotely monitored exercise program for 150 people with a type of heart failure called HFpEF. The goal is to see if the program improves heart function, muscle health, and quality of life. Participants will follow a structured exercise plan and be…

This study tests whether a ketone drink can improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF). Twenty participants will receive either the ketone drink or a placebo for 8 weeks, then switch. The main goal is to see if the drink helps …

This observational study follows 95 people with heart failure and preserved ejection fraction who are already receiving weight loss treatment as part of their standard care. Researchers will measure muscle blood flow, fat content, and inflammation before and after at least 7% wei…

This observational study aims to capture a real-world snapshot of how heart failure is managed across Europe and worldwide. Researchers will collect data from about 4,000 adults with chronic or acute heart failure, looking at whether routine care aligns with the 2021 ESC guidelin…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare 60 adults with and without HFpEF using tests like MRI, exercise testin…

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study looks at why Veterans with heart failure with preserved ejection fraction (HFpEF) get tired so easily during exercise. Researchers will block nerve signals from leg muscles to see how that affects blood flow and fatigue, both before and after a regular exercise program…

This study tests whether a noninvasive procedure called remote ischemic preconditioning can improve blood vessel function in people with suspected heart failure with preserved ejection fraction. Participants will have a blood pressure cuff inflated around their arm in cycles, whi…

This study looks at whether special heart MRI scans can help predict serious events like death or hospital stays in people with a type of heart failure called HFpEF (heart failure with preserved ejection fraction). Researchers will scan 3000 patients with HFpEF and 500 healthy vo…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…

This study creates a registry of 240 patients hospitalized with decompensated heart failure with preserved ejection fraction. Researchers will track medical history, body composition, imaging, and blood markers to see how these factors relate to short- and long-term outcomes. The…

This study looks at tiny RNA molecules in the blood of 200 people hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive decongestive therapy and if they can help predict who will respond well to treatment. The goa…

This study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body chemicals and kidney f…