Constipation disorder

This trial tests whether fluoxetine, a common antidepressant, can improve bowel function in adults with chronic constipation that has not responded to standard laxatives. Participants also show features of somatic symptom disorder, where emotional distress appears as physical sym…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant, or FMT) combined with prebiotics can relieve chronic constipation. Nineteen adults with hard-to-treat constipation will receive the treatment via colonoscopy. The goal is to improve bowel mo…

This trial tests whether a new non-invasive device, called Body Surface Colonic Mapping, can accurately measure colon movement in children. The device uses a sticky pad with electrodes placed on the abdomen to detect electrical activity from the colon. Researchers will compare it…

This study tests whether an artificial intelligence (AI) tool can help doctors spot precancerous growths in the upper part of the colon during a colonoscopy. About 1,200 people with symptoms like belly pain, constipation, or black stools will take part. The goal is to see if usin…

This study will test whether a procedure called high-resolution anorectal manometry can help doctors figure out why some children have severe constipation that doesn't get better with standard treatments. The researchers will measure muscle and nerve function in the rectum and an…

This trial tests whether laser acupuncture, a non-invasive treatment using light on specific back points, can ease constipation and improve sleep in people with Parkinson's disease. The study includes 60 participants with Parkinson's and constipation, who will receive either real…

This trial tests whether adding low-level laser therapy to a standard program of diet changes and biofeedback training can help women with obstructive defecation syndrome (ODS), a condition that makes it hard to empty the bowels. Women aged 30-45 with ODS will be randomly assigne…

This trial investigates whether a traditional Chinese medicine formula, Xingqi Daozhi Decoction, can relieve constipation that often occurs as a side effect of antipsychotic medications in people with schizophrenia. The study will enroll 46 adults with schizophrenia who have deve…

This study looks at whether combining core-based movement exercises with nutritional counseling can reduce stress, improve cholesterol levels, and ease constipation in overweight women with functional constipation. Sixty women will be split into two groups: one gets both exercise…

This study compares transanal irrigation (using a device to rinse the bowel) against standard care (diet, fluids, laxatives) for treating severe constipation in people with Parkinson's disease. Researchers will also check if the treatment affects gut bacteria and motor symptoms. …

This phase II trial investigates whether a specially formulated yogurt rich in butyrate—a short-chain fatty acid—can relieve constipation in people with gastrointestinal cancer. Constipation is a common and distressing side effect of cancer and its treatments, and current medicat…

This trial tests whether adding physical therapy—including spinal joint mobilization, electrical muscle stimulation, and gentle abdominal techniques—to standard medical care can reduce constipation severity and improve quality of life in adults with functional constipation. Sixty…

This study tests whether Shouhui Tongbian Capsules, a traditional Chinese herbal medicine, can relieve constipation after surgery for benign anal or rectal conditions like hemorrhoids. 120 adults will be randomly assigned to take either the herbal capsules or a standard laxative …

This study tests whether adding Kinesio Taping to a standard bowel program can improve bowel function in adults with spinal cord injury. Thirty participants will be randomly assigned to receive either the bowel program alone or the bowel program plus Kinesio Taping applied to the…

This study investigates whether taking acacia fiber daily can improve bowel movement frequency and stool consistency in healthy adults who sometimes get constipated. Participants take either a low or high dose of acacia fiber or a placebo for about eight weeks. Researchers also l…

This study looks at whether starting trans-anal irrigation (a procedure that uses warm water to help empty the bowel) within three months of stoma closure reduces daily bowel movements more than starting later. The trial involves 250 adults who have had rectal cancer surgery and …

This study compares two laxatives, Senna and polyethylene glycol (PEG), to see which better reduces accidental bowel leakage in children with long-term constipation. About 80 children aged 4 to 18 will take one of the two medicines daily for 3 months, and neither the families nor…

This study tests whether a daily probiotic supplement called BLa36 can improve constipation in adults. Over 8 weeks, 105 participants will take either the probiotic or a placebo. Researchers will track stool consistency, gut health, and quality of life to see if the probiotic off…

This study tests whether a daily probiotic supplement can help relieve constipation in adults. Thirty participants will take either a probiotic or a placebo for 8 weeks. Researchers will track changes in stool consistency to see if the probiotics improve bowel function.

This study is testing a special probiotic supplement in 30 adults aged 50-65 who have ongoing bowel issues like constipation, irritable bowel syndrome, or stomach pain. The goal is to see if the probiotic can improve gut immunity, balance gut bacteria, and ease symptoms like bloa…

This study tests whether a daily fiber supplement (Materna® Opti-fiber) plus nutrition counseling can help pregnant women with constipation. About 31 women between 13 and 27 weeks of pregnancy will take the supplement for 4 weeks. Researchers will track changes in stool frequency…

This study tests whether electroacupuncture can help women with constipation after childbirth. About 60 women within 6 weeks of delivery will receive the treatment, and researchers will measure changes in stool consistency and quality of life. The goal is to find a safe, drug-fre…

This study tests a traditional Chinese medicine capsule, Shouhui Tongbian, to see if it can relieve constipation caused by opioid painkillers in cancer patients. About 270 adults with stable cancer and opioid-induced constipation will take either the capsule or a standard laxativ…

This study tests whether a daily mix of a probiotic (Bifidobacterium longum W11) and a prebiotic (Colopectin) can help children aged 2 to 6 with functional constipation stop taking macrogol laxatives without symptoms returning. One hundred children will receive either the supplem…

This study tests whether a 14-day course of the antibiotic rifaximin can reduce bothersome bloating in adults with irritable bowel syndrome, functional constipation, or similar gut disorders. About 78 participants will receive either rifaximin or a placebo, and researchers will m…

This study compares two types of catheters used for bowel irrigation to help people with chronic constipation and/or fecal incontinence. About 66 adults will be randomly assigned to use either a new self-retaining catheter or a standard balloon catheter. Participants will be trai…

This study tests whether a functional food called Benemix® can safely improve bowel movements in adults with constipation. Eighty adults will take Benemix® daily for 15 days and track their bowel habits and any side effects. The goal is to see if this food product can ease consti…

This study tests two doses of linaclotide (72 mcg and 145 mcg) against a placebo in 90 adults with chronic constipation. Participants take the drug daily for 8 weeks and record their bowel movements and symptoms. The goal is to see if linaclotide improves bowel function and reduc…

This study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …

This study tests whether a combined exercise and abdominal massage program can improve bowel function and daily well-being in children aged 5-18 with functional constipation. Researchers will compare the program to standard care by measuring symptoms, rectal size, and quality of …

This study tests whether drinking oat milk every day for 4 weeks can improve bowel movements in adults with constipation. About 100 participants will either drink oat milk or continue their normal diet. Researchers will track changes in gut bacteria, symptoms, and stool frequency…

This study will test whether standing on a whole-body vibration platform can improve constipation in women who have gone through menopause. Fifty women aged 50–60 will either receive standard bowel care advice or that advice plus vibration sessions. The goal is to see if the vibr…

This study will follow 100 people with severe obesity who are starting a GLP-1 drug (like Ozempic or Wegovy) to see if it causes new anal or rectal problems within the first 3 months. Participants will have a check-up before starting the drug and again after 3 months to look for …

This study looks at whether giving fish oil nutrition before colon surgery helps patients with constipation recover better. About 306 adults will either get fish oil before surgery or only after. Researchers will compare complication rates, recovery, and quality of life. The goal…

This study will create and test simple picture-based tools (pictograms) to help children aged 8 to 17 describe symptoms like constipation, bloating, and stomach pain. Many kids struggle to explain what they feel, which can lead to misdiagnosis. The goal is to see if these pictogr…

This study follows 80 adults who had a tube placed into their bowel (called a percutaneous endoscopic caecostomy, or PEC) to treat severe chronic constipation that didn't improve with standard treatments. Researchers will check long-term quality of life and how well the tube work…