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Could a poop transplant cure your constipation?

NCT ID NCT07386795

Disease control Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant, or FMT) combined with prebiotics can relieve chronic constipation. Nineteen adults with hard-to-treat constipation will receive the treatment via colonoscopy. The goal is to improve bowel movements and gut health, with researchers monitoring safety and changes in the microbiome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fecal microbiota transplant (FMT) combined with prebiotics
What this could lead to
If successful, this approach could offer a new, safer treatment option for people with chronic constipation that doesn't respond to standard therapies.
What could go wrong
This is a very small, early-stage trial with only 19 participants and no comparison group, so results may not apply widely. Side effects like bloating, diarrhea, or rare infections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 19 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with functional constipation (FC) according to Rome IV criteria. * Symptoms persisting for at least 6 months, with criteria met for the last 3 months. * Ineffective response to traditional treatments (dietary intervention, at least 2 types of laxatives, or probiotics). * Willing to discontinue other constipation medications, herbal medicines, or supplements during the study. Exclusion Criteria: * History or clinical evidence of mechanical bowel obstruction (e.g., tumor or hernia). * Diagnosis of megarectum, megacolon, or pseudo-obstruction. * Organic intestinal abnormalities (obstruction, stenosis, cancer) or inflammatory bowel disease (IBD). * Progressive colorectal polyps requiring treatment. * History of gastrointestinal or abdominal surgery within the past 3 months. * Severe cardiovascular or cerebrovascular diseases. * Clinically significant liver function abnormalities (ALT/AST \> 2x ULN, TBIL ≥ 1.5x ULN). * Pregnancy, lactation, or planning to conceive during the study. * Inability to undergo colonoscopy or catheter placement. * Participation in other clinical trials within the past 3 months. * Other health conditions deemed unsuitable by the investigator.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic constipation Constipation - functional Fecal microbiota transplantation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Peking Union Medical College Hospital

    Beijing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.