Chronic ulcer of skin

This study tests whether shining a specific red light on bedsores (pressure ulcers) can help them heal faster. About 46 ICU patients with stage II bedsores will either get the light treatment plus standard care, or standard care alone, for 14 days. Researchers will track wound si…

This study tests whether adding cold plasma therapy to standard wound care helps heal large chronic leg ulcers faster. About 120 adults with non-healing wounds will receive either standard care alone or standard care plus a 4-week plasma treatment. The main goal is to see if the …

This trial is testing a new stent (a small mesh tube) to treat blockages in the large vein in the abdomen (inferior vena cava) and nearby leg veins. The study involves 136 adults with symptoms like leg ulcers, pain, or swelling. Doctors will place the stent to keep the vein open …

This study looks at how safe and effective a dehydrated human placenta tissue product is for healing chronic wounds like diabetic foot ulcers, venous leg ulcers, and pressure ulcers. Researchers will review medical records of 300 adults whose wounds were treated with this product…

This study tests whether a special placental membrane called BR-AC, applied weekly, can help heal non-healing venous leg ulcers faster than standard care alone. About 60 adults with a leg ulcer between the knee and ankle will be randomly assigned to get either standard care plus …

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This study tests whether a patch made from donated human placenta tissue, plus standard wound care, helps close nonhealing venous leg ulcers better than standard care alone. About 70 adults with ulcers present for at least 4 weeks will take part. Those who get standard care first…

This study tests whether adding special wound dressings (called CAMPs) to standard care helps close hard-to-heal diabetic foot and leg ulcers better than standard care alone. About 350 adults with these ulcers will be randomly assigned to receive either the extra dressings or usu…

This trial compares repositioning a pulse oximeter probe every 2 hours versus every 4 hours in adult intensive care patients. The goal is to see if more frequent repositioning reduces medical device-related pressure injuries. The study involves 432 patients who are monitored for …

This study tests whether sap from the Pterocarpus indicus tree can help heal small skin ulcers (sores) in remote areas of Papua New Guinea. 222 people with sores smaller than a dime will get either the plant sap, Savlon antiseptic cream, or no treatment. Researchers will check he…

This trial tests a two-step treatment for chronic lower leg wounds that have not healed for over a month. First, a motorized waterjet cleans the wound, then a motion-based suction device applies negative pressure to promote healing. The study includes 50 adults with various types…

This study tests whether a repairing gel (Supraz) combined with a platelet-rich plasma-fibrin glue can eliminate odor and help heal chronic wounds that haven't improved with standard care. About 40 adults with a single wound lasting at least 3 months will receive either the new t…

This program offers selexipag (Uptravi) to a single patient with Buerger's disease who has a wound that won't heal. The goal is to see if the drug can help control the disease and improve wound healing. This is not a cure, and the patient may need ongoing treatment.

This study tests whether adding a device that delivers mild electrical pulses (intermittent electrical stimulation) to standard care (turning patients every two hours) helps heal stage 1 or 2 bedsores on the lower back or tailbone. About 1,100 hospitalized adults will be randomly…

This study tests whether a device called Sonablate can safely use high-intensity focused ultrasound (HIFU) to treat vein problems like varicose veins, leg ulcers, and certain birth defects. About 30 adults with these conditions will receive the treatment, which does not involve c…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This early-stage study tests whether a person's own fat stem cells can safely help heal pressure ulcers or diabetic foot ulcers. Twelve adults will have a small amount of fat removed from their body, processed to extract stem cells, and then applied to their wound using a special…

This study tests a special dressing called EDX110 on 43 people with hard-to-heal wounds from diabetes or poor leg circulation. The dressing creates a gas called nitric oxide to help clean and heal the wound. Researchers will measure how much the wound shrinks over 12 weeks and ho…

This study looks at whether adding amniotic membrane products to standard wound care helps diabetic foot ulcers, venous leg ulcers, and pressure ulcers heal faster. Researchers will compare healing rates in 2,400 adults treated with these grafts versus those receiving standard ca…

This study looks at whether adding four types of amniotic membrane grafts to standard care helps heal chronic wounds like diabetic foot ulcers, venous leg ulcers, and pressure ulcers faster. Researchers will track 2,000 adults to see if wounds close completely within 12 weeks and…

This phase 3 trial tests a donor stem cell treatment called Allo-APZ2-CVU for people with chronic venous leg ulcers that haven't healed with standard therapy. About 250 adults with ulcers between 1 and 25 cm² will receive either the cell therapy or a placebo applied directly to t…

This study tests whether a special lipid cream (EpiCeram) can prevent healed chronic wounds—like diabetic foot ulcers or pressure sores—from reopening. About 100 adults with recently healed wounds will apply either the cream or Vaseline for 3 months. Researchers will measure skin…

Chronic wounds are slow-healing skin injuries often linked to diabetes, poor circulation, or pressure. Doctors usually judge these wounds by eye, which can lead to inconsistent assessments. This pilot study tests whether a combination of non-invasive imaging techniques, including…

This trial is testing whether an AI system can measure the area of pressure ulcers (bedsores) as accurately as the traditional manual grid-counting method, but in less time. Adults with pressure ulcers will have a transparent grid film placed on their wound, and a single photo wi…

This study tests how accurately doctors, nurses, and technicians can diagnose ear barotrauma (pressure injury to the ear) using two different grading systems: the TEED score and the O'Neill Grading System (OGS). Thirty healthcare providers will grade 120 photos of eardrums to see…

This study compares a new device, cureVision cV, to an existing one (MolecuLight i:X) to see if it can accurately detect moderate to high levels of bacteria in wounds. About 100 adults with various wound types (like diabetic foot ulcers or surgical wounds) will be enrolled. The g…

This study tests a handheld device called the SEM Scanner that detects early skin damage up to 10 days before it's visible. Nursing home staff will use it during weekly skin checks to decide when to start prevention care. The goal is to reduce painful pressure injuries, especiall…

This study tests whether a topical oil made from palmitoleic acid can prevent pressure injuries (bedsores) in hospitalized adults at high risk. Sixty participants will apply the oil to their lower back four times daily for two weeks. Researchers will monitor skin moisture and oxy…

This study tests whether placing color-coded cards at the bedside of ICU patients can help nurses prevent pressure injuries (bedsores). The cards use red, yellow, and green to show high, medium, or low risk. Researchers will track 96 patients over 5 days to see if this simple vis…

Researchers are collecting real-world data on the geko device, a small wearable that stimulates the peroneal nerve in the leg, for people with lower-leg ulcers. The registry follows about 2,500 adults who use the device as part of their standard wound care for up to 12 weeks. It …

This small study is testing Corplex P, a device made from donated human umbilical cord tissue, to see if it helps heal wounds that won't close on their own, like diabetic foot ulcers. Ten people will receive the device as part of their standard wound care. Researchers will track …

This study tests whether adding laser light therapy to standard wound care helps heal hard-to-heal ulcers in frail older adults receiving home healthcare. About 1,290 participants will receive the laser treatment on their wounds and nearby lymph areas. Researchers will track heal…

This study tests whether injecting platelet-rich plasma (PRP) directly into grade III ulcers can speed up healing. PRP is made from a small amount of the patient's own blood, processed to concentrate healing factors. Fifty adults with ulcers older than two weeks will receive eith…

This study was designed to test the safety and performance of the Avelle negative pressure wound therapy system on chronic wounds, including diabetic foot ulcers and venous leg ulcers. The device uses gentle suction to help wounds heal. However, the study was withdrawn before enr…

This study looks at whether blood oxygen levels and other blood gas measurements are linked to the risk of developing pressure injuries (bedsores) in intensive care patients. Researchers will monitor 122 adults who have been in the ICU for at least 72 hours, tracking their blood …

This study looks at what intensive care nurses know and do to prevent pressure sores (bedsores). Researchers will survey and interview 60 nurses to find out their knowledge level and learn from their real-world experiences. The goal is to identify gaps in training and improve pat…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study looks at how low-level laser therapy (red light at 660 nm) affects the stiffness of chronic and burn wounds. Researchers will measure stiffness before and after a 3-minute laser treatment using two devices: OCT and MyotonPRO. The goal is to see if laser therapy changes…