Chronic asthma

This phase 3 trial is testing an experimental mRNA vaccine called mRNA-1345 to see if it can protect against respiratory syncytial virus (RSV) in adults who are at high risk of severe illness. The study includes two groups: adults aged 18 to 59 with chronic health conditions like…

This study looked at whether adding special breathing muscle training to a swimming program could improve asthma control in children with mild asthma. Thirty children aged 8-11 took part in a 4-week swimming program, with half also doing breathing exercises twice daily. Researche…

This study tested a drug called tezepelumab in 287 adults and teens with severe asthma, including groups often left out of research. The goal was to see if the drug reduces asthma attacks and is safe over 52 weeks. Results showed fewer flare-ups compared to the year before starti…

This phase 2 trial tests a needle-free epinephrine nasal spray (ARS-1) for managing asthma symptoms. People with persistent asthma receive a single dose of ARS-1, albuterol, or placebo in random order. The study measures how well the spray improves lung function compared to stand…

This study followed 105 teenagers with severe uncontrolled asthma who were starting treatment with dupilumab (Dupixent). Researchers tracked their asthma control, flare-ups, and safety over one year. The goal was to see if this medication helps teens manage their condition better…

This study looked at 28 adults with both severe asthma and chronic sinusitis with nasal polyps who were treated with dupilumab for 24 months. The goal was to see if the drug could help control both conditions at the same time, called 'dual remission.' After 24 months, 88% of pati…

This study tested a new drug called verekitug (UPB-101) in 479 adults with severe asthma. The goal was to see if it could reduce asthma attacks and improve lung function compared to a placebo. Participants received either verekitug or a dummy injection over several months. The tr…

This completed Phase 2 trial tested several different drugs in 950 people with severe asthma. The goal was to see which treatments improve lung function and control symptoms. Participants tried each treatment for 16 weeks, with breaks in between, to find the best match for their …

This pilot study tested a digital health platform that combines a smartphone app and connected inhaler sensors to help people with asthma track their medication use and technique. 94 adults with uncontrolled moderate-to-severe asthma in the UK used the platform for 6 months. The …

This study tested whether a combination inhaler (CHF 1535, containing both a steroid and a long-acting bronchodilator) works better than a steroid-only inhaler in adults whose asthma is not well controlled despite high-dose steroids or medium-dose steroids plus another bronchodil…

This study looked at how well the drug tezepelumab works for people with severe asthma when used in real-world settings, not just in controlled trials. Over 500 participants aged 12 and older were followed after starting tezepelumab. The main goal was to see if their asthma sympt…

This study looked at how well benralizumab (Fasenra) works for people with severe eosinophilic asthma in real-world clinics across the Gulf, Latin America, and India. Researchers tracked 291 patients to see if their asthma control improved over time using a standard questionnaire…

This early-phase study tested a new drug called RC1416 in 40 adults with moderate to severe asthma. Participants received a single injection of either the drug or a placebo. The main goal was to check safety and how the body processes the drug, with a preliminary look at whether …

This study looked at whether dupilumab, a drug that blocks certain immune signals, can reduce signs of autoimmunity in the airways of people with severe asthma. 30 patients were followed for 4 months. The goal was to see if this approach could help those who don't get better with…

This study tested a drug called tezepelumab in 305 adults with severe asthma who were already taking daily steroid pills. The goal was to see if tezepelumab could help them safely reduce or stop their oral steroids without losing asthma control. Participants received tezepelumab …

This study tested an experimental drug called TQC2731 in 205 adults with severe asthma that is not well controlled by standard treatments. The drug is a lab-made antibody that blocks a protein involved in asthma inflammation. Participants received either one of three doses of TQC…

This study looked at how well tezepelumab works for people with severe asthma when used in everyday medical practice, outside of a clinical trial. Researchers tracked 33 patients in Spain who received the drug through a special access program. The goal was to see how the drug aff…

This study looked at 205 pairs of caregivers with major depression and their children (ages 7-17) with asthma. Caregivers could choose to take standard antidepressant medication or not. Researchers tracked changes in the caregiver's depression and the child's asthma control over …

This study tests a new medicine called FB704A in adults with severe asthma. The goal is to see if it is safe and can help control asthma symptoms. About 20 people will receive either the drug or a placebo over 8 weeks, with follow-up for 12 more weeks.

This study tested a procedure called bronchial thermoplasty for people with severe asthma that is not controlled by standard treatments. The treatment uses heat to thin the airway muscles, aiming to reduce breathlessness during exercise. 14 participants were enrolled, and the mai…

This study tested whether a special breathing exercise, called flow-resistive inspiratory muscle training, could reduce the severity of exercise-induced bronchoconstriction (EIB) in athletes with asthma. Fifteen competitive cyclists or athletes aged 18-35 completed the training a…

This study tested two types of exercises in 54 adults with chronic asthma: one that stretches the upper back and one that pulls the shoulder blades back. The goal was to see if these exercises could improve chest expansion, lung function, and shortness of breath. Participants did…

This study tested two types of breathing exercises—diaphragmatic breathing and pursed-lip breathing—in 60 Egyptian adults with mild to moderate asthma. Participants did the exercises for 20 minutes twice a day, five days a week, for eight weeks. The goal was to see if these exerc…

This pilot study tested whether weekly reminder messages help adults with severe asthma stick to home-based lung function monitoring using a digital device. Thirty patients used the AioCare spirometry system for 12 weeks. Those who got reminders completed more monitoring sessions…

This study followed 112 adults with severe asthma who were starting treatment with dupilumab (Dupixent). Researchers measured changes in quality of life using a standard questionnaire at 12, 24, and 52 weeks. The goal was to see if the drug helps people feel better and breathe ea…

This study follows 500 people in China with moderate-to-severe asthma to see how doctors adjust their treatments over 24 weeks. Researchers focus on patients whose symptoms remain uncontrolled despite using standard inhaler therapy, and they track whether these patients are moved…

This observational study looks at why some people with severe asthma continue to have flare-ups even while taking tezepelumab, an approved treatment. Researchers will track 150 patients over a year, measuring changes in inflammatory cells and markers in blood and airways during a…

This study involved over 9,000 adults in China who might have asthma. Researchers tested a program where doctors were rewarded for helping the whole community's health. People in the program got health checks, lung tests, and advice on smoking, mental health, weight, and blood pr…

This completed study looked at 54 children with severe asthma to better understand the different biological features (endotypes) of the disease. Researchers collected blood, saliva, and nasal samples, along with lung samples from bronchoscopies, to analyze immune cells, metabolis…

This study looked at how the COVID-19 pandemic affected the quality of life of 200 adults with asthma. Researchers wanted to understand what caused extra stress—like staying home, using more disinfectants, or worrying that asthma symptoms might be COVID-19. The goal was to find o…

This study looked back at medical records of 352 adults with severe asthma who started taking tezepelumab in UK hospitals between January 2023 and March 2024. Researchers wanted to see how often patients had asthma attacks and whether they needed oral steroids during the year aft…

This study looked back at medical records of 420 people with severe asthma in Spain who were given tezepelumab after it was approved. The goal was to see how well the drug works in real life, not just in controlled trials. Researchers tracked things like asthma attacks, symptoms,…

This study looked at 174 adults with severe asthma who were starting biotherapy. Researchers wanted to see if their ability to work (despite health issues) improved after 6 months of treatment. The goal was to understand which factors, like asthma control or other health problems…

This study looked at how often people with severe asthma also have inducible laryngeal obstruction (ILO), a condition where the voice box closes during exercise, making breathing harder. Researchers tested 116 participants using a special scope while they walked on a treadmill an…

This study looked at CT scans from 233 severe asthma patients to see if body composition (like chest muscle size and quality) could predict how well they respond to biologic therapies. Researchers used advanced imaging analysis to find biomarkers linked to fewer asthma attacks. T…

This completed study looked back at medical records of 74 adults in Portugal with severe eosinophilic asthma who were treated with benralizumab. Researchers wanted to describe patient characteristics, treatment patterns, and outcomes in real-world settings. The study did not test…

This study measured the amount of mepolizumab in the blood of 50 adults with severe asthma who were already taking the drug. Researchers compared drug levels between those who responded well to treatment and those who did not. The goal was to see if differences in how the body pr…

This completed study took blood samples from 4 people with severe asthma or a related condition called ABPA. Researchers used the blood cells to create stem cells and then grew them into tiny models of bronchial tissue. The goal was to see if this lab-grown tissue could mimic rea…

This study measured how often people with severe asthma in Egypt use oral corticosteroids (OCS), a common but strong medication. Researchers looked at 201 patients across multiple clinics to understand treatment patterns and asthma types. The goal was to gather information, not t…

This completed study followed 18 adults with severe asthma in the United States for at least 3 years. Researchers collected data on treatments, symptoms, hospital visits, and quality of life from medical records and monthly patient surveys. The goal was to understand how severe a…