Helping Mom's mood may help Kid's asthma
NCT ID NCT02809677
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at 205 pairs of caregivers with major depression and their children (ages 7-17) with asthma. Caregivers could choose to take standard antidepressant medication or not. Researchers tracked changes in the caregiver's depression and the child's asthma control over one year to see if improvement in one led to improvement in the other.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- antidepressant medication (standard care for major depressive disorder)
- What this could lead to
- If successful, this could show that treating a caregiver's depression helps control their child's asthma, pointing to a new way to manage childhood asthma.
- What could go wrong
- This is an observational study, not a randomized trial, so results may be less reliable. It also does not test a new treatment, only the effect of existing depression care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
205 people
The number who actually took part.
- Started
-
Jun 2016
- Finished
-
Oct 2020
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
7 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Caregiver: Male or female, ages 18 to 70, primary asthma caregiver of the child, currently meeting criteria for Major Depressive Disorder (MDD) (based on depression symptoms for at least 2 weeks and causing clinically significant distress or impairment in social, occupational, or other important areas of functioning) based on a Structured Clinical Interview for DSM-4 (SCID) interview. * Child: Male or female, ages 7-17 years who have a diagnosis of persistent asthma as classified by either of the following criteria: * A. requirement for treatment with daily controller medication; or * B. symptoms of persistent asthma in children not on a daily controller medication: * 1\. Daytime symptoms two or more days per week; or * 2\. Rescue bronchodilator use two or more times per week; or * 3\. Nocturnal symptoms two or more nights per month; or * 4\. Two or more oral steroid bursts in the last year. Exclusion Criteria: * Caregiver: Severe cognitive impairment that could impair their ability to provide informed consent; member of a vulnerable population (incarcerated, pregnant or breastfeeding women); women of childbearing age who will not use acceptable methods of birth control or abstinence during the study; severe psychiatric disorder in addition to MDD that should be a primary focus of treatment (e.g. severe and disabling eating or anxiety disorders); treatment refractory depression defined as failing ≥ 3 adequate trials of antidepressants (≥ 4 weeks at a therapeutic dose); electroconvulsive therapy or repeated transcranial magnetic stimulation during the current episode; depression as part of bipolar disorder or schizophrenia or schizoaffective disorder, or current depression secondary to substances or general medical condition, or with psychotic features or accompanied by severe obsessive compulsive disorder (OCD), or high risk for suicide defined by multiple recent suicide attempts (\> 2 in the past year) or any attempt in the past month, or current suicidal ideation with a well-formed plan or intent. * Child: Severe cognitive impairment that could impair their ability to provide informed consent; high risk for suicide defined by multiple recent suicide attempts (\> 2 in the past year) or any attempt in the past month, or current suicidal ideation with a well-formed plan or intent; severe or life-threatening medical illness, such as other serious cardiopulmonary conditions (e.g. congenital heart disease, cystic fibrosis, alpha-1-antitrypsin disease) or cancer, which would confound the assessment of asthma, anxiety, depression or quality of life; severe psychiatric illness, such as autism, bipolar disorder, schizophrenia or current drug/alcohol abuse/dependence. If an eligible caregiver presents with more than one child meeting inclusion criteria for the study, only one child, randomly selected, will be enrolled.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Asthma are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Texas Southwestern Medical Center Psychoneuroendocrine Research Program
Dallas, Texas, 75235, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a simple breath test cut asthma Flare-Ups?
- Breathing tests face off: can extra lung measurements improve asthma diagnosis?
- Can an antipsychotic restore feelings in people with depression?
- The carbon label on your inhaler: can it sway a Doctor's choice?
- Can intense brain zaps lift depression? scientists track blood flow in real time
- Can an ancient herbal capsule boost antidepressant power?