Burn

This trial tests an engineered skin graft called denovoSkin™, made from a patient's own skin cells, for treating deep burns. It aims to see if this graft can close wounds and reduce scarring better than the standard split-thickness skin graft. The study includes adults and adoles…

This trial tests a lab-grown skin substitute made from a patient's own cells as a permanent replacement for severe burn wounds. It is for people with deep burns covering over half their body, where donor skin is scarce. The study compares how well this substitute grafts and heals…

This study tests whether giving plasma (a part of blood) as soon as possible to adults with severe burns over at least 20% of their body can lower the chance of death or organ failure. About 750 patients will be randomly assigned to receive either early plasma or standard fluids.…

This study compares two medications applied to the wound bed before placing a skin graft in people with burns. The goal is to see if a low-cost drug called tranexamic acid works as well as the standard thrombin spray to prevent blood clots under the graft. About 62 adults with sm…

This trial compares a new biodegradable wound dressing, SupraSDRM®, to standard care for full-thickness wounds—such as severe burns, surgical wounds, or traumatic injuries—that are not ready for immediate skin grafting. The goal is to see if SupraSDRM® helps wounds heal faster an…

This study tests whether using a person's own fat, combined with a skin graft, can improve tight scars from burns or injury better than standard skin grafting alone. Forty adults with scar contracture will receive either the new fat-plus-skin method or the usual full-thickness sk…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This pilot study tests a new way to make a custom pressure orthosis for burn scars using 3D scanning and printing. About 25 adults with healing hypertrophic burn scars will get the device. The main goal is to see if the manufacturing process works and the orthosis fits safely.

This study tests whether a gel made from umbilical cord stem cells can help heal severe burns faster and more safely. About 90 adults with burns covering less than 30% of their body will receive either a low-dose, high-dose, or placebo gel on their donor skin site. The main goal …

This study tests whether a gel made from human umbilical cord stem cells and cow collagen can safely help third-degree burn wounds heal faster. About 108 adults with burns covering 1-5% of their body will receive the gel or a placebo. The main goal is to see how much and how quic…

This Phase 2 trial tests whether 4-aminopyridine, a drug already used for other conditions, can help second-degree burns heal faster. Researchers will give the drug or a placebo to 200 adults with fresh burns and track healing rate and scarring. The goal is to see if this safe, e…

This pilot study tests a device called Efferon LPS that filters the blood to remove toxins and inflammatory substances in adults with severe thermal burns. Fifteen participants will receive two filtering sessions, and their outcomes will be compared to a group of similar patients…

This study tests whether giving antibiotics before burn surgery lowers the chance of infections after the operation. About 506 adults with burns covering 5% to 40% of their body will take part. Half will get antibiotics before surgery, and half will get a placebo. The goal is to …

This study tests a device called Efferon LPS NEO that filters the blood of children with severe burns to remove harmful substances. The goal is to see if it reduces time in the ICU and improves recovery. Thirty children will receive the treatment and be compared to past cases.

This Phase 3 trial tests whether giving the steroid dexamethasone early after a severe burn can prevent major complications like lung or kidney failure and reduce death. About 478 adults with burns covering at least 20% of their body and on a breathing machine will receive either…

This study looks at whether two simple blood test results—the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio—can help predict which children with severe burns will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will foll…

This phase 2 trial tests whether ketamine-assisted psychotherapy (KAP) can safely ease PTSD and trauma symptoms in adults with severe burns covering more than 15% of their body. Twelve participants will receive two KAP sessions plus a preparatory talk therapy session. The main go…

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests whether a special laser can make burn scars look and feel better. Researchers will treat mature burn scars on the body and measure changes in scar height, texture, color, and flexibility. The study involves 6 adults in Winnipeg with scars that are 6-12 months old…

This study tests whether a drug called phenylephrine can control bleeding during burn surgery as well as the standard drug epinephrine, but without causing unwanted changes in heart rate or blood pressure. About 24 adults with burns needing skin grafts will take part. The goal is…

This study tests a special gel dressing called Plurogel against standard burn dressings in people with partial thickness burns on the face or one limb. The goal is to see if Plurogel helps burns heal faster, reduces pain, and lowers the need for skin grafts. About 25 adults will …

This early-phase trial tests whether disposable nitrous oxide (laughing gas) canisters can reduce pain and anxiety during burn dressing changes. Thirty adult burn patients will try both the gas and a placebo in random order. The goal is to see if this offers a safer alternative t…

This pilot study tests whether a gel called PluroGel®, used with standard dressings, can help burn injuries heal better and reduce the need for skin grafting. Twenty adults with similar burns on both arms or legs will have one limb treated with the gel and the other with standard…

This study looks at whether pulsed dye laser therapy can make burn scars less red, softer, flatter, and more flexible. Researchers will treat people with burn scars that are 1 to 6 months old and living in Winnipeg. The goal is to see if the laser helps scars heal better.

This study tests a cream containing FS2 (kynurenic acid) to see if it can reduce scarring in burn patients who need skin grafts. About 70 people aged 12 to 65 will apply the cream or a placebo to both the graft and donor sites for 90 days. The goal is to check safety and whether …

This study tests whether a 3D hologram can distract children aged 3 to 12 during painful burn dressing changes, reducing their pain, anxiety, and fear. About 70 children with second-degree burns covering less than 10% of their body will be randomly assigned to see a hologram or r…

This study compares two sedation approaches—dormicum-ketamine versus dexmedetomidine—to see which better prevents emergence delirium (confusion and agitation) in children aged 3 to 16 with burns. Sixty kids undergoing burn dressing changes or minor procedures will be randomly ass…

This study tests whether adding blue light therapy to standard wound care helps donor sites (the area where healthy skin is taken for grafting) heal faster in burn patients. About 25 adults with deep burns will have two donor sites: one treated with standard care alone, the other…

This study tests a new cream called MW-III on partial-thickness thermal burns (like from fire or hot liquids). It compares MW-III to a standard burn cream, Silvadene, to see which helps burns heal faster. About 60 adults with burns covering up to 25% of their body will take part.…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) — done with or without virtual reality (VR) — can ease chronic symptoms like pain, itch, anxiety, and sleep problems in adult burn survivors. About 34 participants will try both VR-enhanced…

This study tests a telerehabilitation program that uses technology to help adults recovering from burns. Participants will do rehab exercises at home with remote guidance. The goal is to see if this approach improves joint range of motion and scar quality. The study enrolls 30 ad…

This study tests a single dose of a new drug called cP12 in 6 adults with thermal burns covering up to 10% of their body. The main goal is to check if the drug is safe and how the body processes it. Researchers will also monitor pain and burn healing for two weeks after treatment…

This study is checking how safe and effective a special dressing (3M V.A.C. Peel and Place) is when used with a standard wound vacuum therapy. About 90 adults with open wounds or surgical incisions will be treated and monitored. The goal is to see if the dressing helps wounds clo…

This study tests a new wound dressing called Field Shield for second-degree burns covering 5-30% of the body. About 40 people will join to see if it helps burns heal faster, with less pain and infection, compared to standard care. The dressing is changed and checked over 35 days.

This study tests if training with a wearable robot can improve walking in people who have long-term walking problems after a severe burn injury. Twenty adults who had burns on more than half of their legs and still had trouble walking 6 months later will receive 12 weeks of robot…

This study compares two sedatives, remimazolam and propofol, given during laser treatment for burn scars. The goal is to see which drug causes fewer breathing problems. About 136 adults will take part, each receiving both drugs in separate sessions. The results could help doctors…

This study compares a new powder dressing called Altrazeal to standard burn dressings in adults with partial thickness burns. The goal is to see if the new dressing reduces pain during changes and helps wounds heal faster. Sixty hospitalized patients will be randomly assigned to …

This study tests a new type of nerve block called LAM for pain after skin graft surgery. The block aims to numb the thigh where skin is taken, without weakening the leg muscles. Ten adults having skin graft surgery will receive the block, and researchers will map how much sensati…

This study tests whether wetting the skin can prevent dangerous rises in body temperature during exercise in hot conditions for burn survivors. Researchers will compare cooling methods in 40 adults, including those with and without burn injuries. The goal is to find a simple way …

This study tests whether a combination of famotidine (Pepcid) pills and cromolyn sodium lotion can reduce itching from burn scars. 44 adults with itchy burn scars will take either the active combo or a placebo (plus a standard antihistamine) for 6 months. The main goal is to see …

This study tests whether a chitosan-based gel (made from natural sources) helps children's burns heal faster and with less scarring than standard silver-based dressings. About 40 children aged 6 months to 17 years with mild to moderate burns will be randomly assigned to one of th…

Researchers are studying the bacteria that live in burn wounds and how they relate to patient outcomes. The trial compares standard laboratory cultures with next-generation DNA sequencing to see if the newer method gives a clearer picture of the wound microbiome. Up to 400 adults…

Researchers are studying how severe burn injuries change the body's ability to control temperature during work and rest in a hot environment. The trial compares burn survivors with healthy adults, measuring core temperature and heart rate during these cycles. The goal is to under…

This study tests whether a simple blood test, taken within 24 hours of a severe burn injury, can help predict a patient's chances of surviving the next 30 days. The test measures the ratio of red cell distribution width to albumin levels, which may reflect inflammation and nutrit…

This study looks at how a serious burn injury changes the way cells produce energy. Researchers will collect blood, urine, and tissue samples from 125 children and adults admitted to the burn center. No new treatments are tested; the goal is simply to learn more about the body's …

This study looks at how a simulated burn injury affects how quickly the body cools down after exercise in hot conditions. Researchers will compare the same person's recovery with and without a special material on the skin that mimics a burn. The goal is to understand if burn surv…

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This study looks at whether using a blood test (anti-Xa) to adjust the dose of a blood thinner (enoxaparin) works better than dosing based on weight alone for preventing dangerous blood clots in burn patients. About 25 adults with serious burns will be enrolled. The goal is to se…

This study looks at how glucose spreads in the body of adults with severe burns (covering at least 30% of their skin). Researchers will measure glucose levels after a small injection over the first four days. The goal is to see if this measurement can help guide fluid treatment i…

This study looks at how the antibiotic cefiderocol behaves in the bodies of people with severe burns. Researchers want to find the best dose to kill bacteria and prevent resistance. The study will enroll 12 adults with burns who have good kidney function.

This observational study tracks 200 adults with severe burns (over 30% of body surface) to see if giving albumin in the first 24 hours after injury improves outcomes. Researchers will measure death rates, kidney failure, and severe lung problems within 28 days. The goal is to gat…

This study is testing a Turkish version of the Burnt Hand Outcome Tool (BHOT) to see if it accurately measures recovery in adults with hand burns. About 100 participants will fill out questionnaires and have their hand function tested over six months. The goal is to provide a rel…

This study follows 30 adults with severe burns to see how their gut bacteria change over time. Researchers collect stool samples and measure inflammation and other health markers. The goal is to understand how these microbiome shifts relate to recovery, not to test a new treatmen…

This study tests two noninvasive imaging methods to assess burn wound severity and predict healing. Researchers will enroll 200 burn patients to see if these cameras can accurately determine which burns will heal on their own and which need surgery. The goal is to improve treatme…

This study follows 600 burn patients and 60 healthy people over two years to see how burns change the community of microbes on the skin and in the gut. Researchers will collect swabs, stool, and blood samples at several time points to map these changes. The goal is to better unde…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …