Bronchiolitis

This trial tests whether using a lower oxygen saturation threshold (88%) versus the standard (92%) to decide when to give supplemental oxygen helps children aged 6 weeks to 12 years recover faster from respiratory distress. Participants are randomly assigned to one of two groups,…

This study tested whether using HEPA air filters at home can reduce respiratory symptoms in infants under 12 months who were hospitalized for bronchiolitis. 230 babies were randomly assigned to have either real HEPA filters or placebo filters in their home for 24 weeks. Caregiver…

This study tested whether a monthly oral bacterial extract (Broncho-Vaxom) could prevent wheezing lower respiratory tract infections in infants aged 6-18 months who are at high risk for asthma. Over 800 participants received either the extract or a placebo for 10 days each month …

This study tested whether a bacterial lysate (Broncho Vaxom) can prevent wheezing in infants who were hospitalized for severe bronchiolitis. 173 infants received either the lysate or a placebo for up to 24 months. The goal was to see if the treatment reduces the number of wheeze …

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study looked at 300 infants under 6 months old with severe bronchiolitis in the pediatric ICU. Researchers compared two flow rates of high-flow nasal cannula (2 vs 3 liters per minute per kilogram) to see which one reduced breathing failure within 24 hours. The goal is to fi…

This study tested a new ventilator mode called NAVA for people with chronic obstructive pulmonary disease (COPD) who need a breathing machine. NAVA uses the patient's own diaphragm signals to control the machine, aiming to improve comfort and reduce time on the ventilator. The st…

This study tested two different spacer devices (valved holding chambers) used to give asthma medicine to children aged 6 months to 4 years with sudden wheezing. 80 children from Finnish hospitals took part. The goal was to see if one spacer worked better for symptom relief, hospi…

This study looked at 80 children aged 1 month to 5 years with severe breathing problems from pneumonia or bronchiolitis. It compared two non-invasive breathing support methods: High Velocity Nasal Insufflation (HVNI) and Nasal Continuous Positive Airway Pressure (CPAP). The goal …

This study tests whether alerts in electronic health records help doctors follow best-practice guidelines for bronchiolitis, a common lung infection in young children. About 8,000 children under 2 years old will take part. Doctors will receive either no alert, a gentle reminder, …

This study measured the peak tidal inspiratory flow (PTIF)—how fast infants breathe in—in 50 babies under 6 months old with moderate to severe viral bronchiolitis. Researchers used a spirometer to record 20 breaths per infant within 24 hours of hospital admission. The goal was to…

This study looked at 46 infants under 2 years old in the pediatric ICU with severe bronchiolitis. Researchers used a heart ultrasound measure called TAPSE to see if it could predict how long babies needed intensive care. The goal was to find a simple test that helps doctors plan …

This study looked at whether a set of care guidelines (called a pathway) could help doctors and nurses in community hospitals use the best treatments for children hospitalized with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across many hospitals. The goal…

This completed study analyzed how doctors in different hospitals treat babies under 2 years old with bronchiolitis, a common lung infection. Researchers looked at 127 children to see if differences in care led to different outcomes, like length of hospital stay. The goal was to u…

This study followed 29 infants who had bronchiolitis in their first year to see if their lung function changes over time and whether that leads to asthma. Researchers measured breathing using special tests and also did allergy skin tests. However, many families dropped out, so th…

This study observed over 1,800 children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It aimed to track how many children were hospitalized for bronchiolitis after a new immunization became available. The study did not test any new treatmen…

This study looked at 20 infants with severe bronchiolitis (a serious lung infection) to compare two types of breathing support: CPAP and NiPPV. The goal was to see which method reduces the effort of breathing more effectively. Researchers measured breathing effort using a special…

This study looked at whether placing infants with severe bronchiolitis on their stomach (prone) while on breathing support reduces their work of breathing. Sixteen babies under 6 months old were randomly assigned to start either on their back or stomach, then switched after an ho…

This study tested a nurse-led weaning protocol for high-flow nasal cannula (HFNC) oxygen therapy in 150 infants aged 1-24 months hospitalized with bronchiolitis. The goal was to see if a structured weaning plan could reduce the time on HFNC, shorten hospital stays, and lower cost…