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Which breathing aid works best for kids? new study compares HVNI and CPAP

NCT ID NCT07336121

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 80 children aged 1 month to 5 years with severe breathing problems from pneumonia or bronchiolitis. It compared two non-invasive breathing support methods: High Velocity Nasal Insufflation (HVNI) and Nasal Continuous Positive Airway Pressure (CPAP). The goal was to see which method improves lung function better and is more comfortable for children, using daily lung ultrasound scores and clinical assessments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High Velocity Nasal Insufflation (HVNI) and Nasal Continuous Positive Airway Pressure (CPAP) devices
What this could lead to
If this study shows one method is better, it could help doctors choose the most effective and comfortable breathing support for young children with breathing problems.
What could go wrong
This is a small, completed study with only 80 children, so results may not apply to all kids. The devices are already in use, so no major new risks are expected, but the study may not find a clear winner.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jan 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 month to 5 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 1 month to 5 years * Admitted to the Pediatric Intensive Care Unit (PICU) * Diagnosed with acute respiratory distress * Failure of low-flow nasal oxygen therapy * Requiring non-invasive respiratory support * Informed consent obtained from parent or legal guardian Exclusion Criteria: * Presence of congenital or acquired cardiac disease * Neuromuscular disorders * Chronic lung disease * History of recurrent wheezing * History of cardio-respiratory arrest * Presence of significant comorbid chronic illness * Contraindication to non-invasive ventilation

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome bronchiolitis Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bronchiolitis Community-acquired pneumonia

Contacts and locations

Locations

  • Pediatric Intensive Care Units, Children Hospital, Ain shams university

    Cairo, 00002, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.