Bone fracture

This study tests satralizumab, a drug that calms inflammation, in 30 children aged 8 to 17 with Duchenne muscular dystrophy. The goal is to see if it improves bone density and muscle function. Participants receive injections for several months while continuing standard steroid th…

This study tests a new total knee replacement system called LinkSymphoKnee, which uses an ultra-congruent bearing surface designed to provide stability and mimic natural knee movement. Researchers will enroll 600 adults aged 18 to 79 who need a knee replacement due to osteoarthri…

This study tests a special nail made from a fiber-reinforced material that integrates with bone over time, instead of staying in the body like metal. Ten people with knee fractures will get the implant and be followed for up to two years. The goal is to see if it reduces pain and…

This study looks at how well Biomet Cannulated Bone Screws work for fixing broken bones, fusing joints, or correcting bone cuts. It includes 51 adults who already had or will have surgery with these screws. Researchers track complications, revisions, and patient feedback to confi…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a new device called VCFix for treating a broken bone in the spine (vertebral compression fracture). Ten adults with a single recent fracture will receive the implant to see if the procedure is safe and works as intended. The goal is to gather early data to plan a…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests whether custom-made positioning guides and titanium plates, designed from a patient's own CT scan, can improve the accuracy and stability of surgery for cheekbone (zygomatic) fractures. Eight adults needing surgery will receive the custom implants, and their resu…

This study tests whether a Fracture Liaison Service (FLS) helps people aged 50 and older who have had a hip or spine fracture. Half of the 400 participants get the FLS, which includes bone health checks, medication guidance, diet and exercise advice, and regular phone follow-ups …

This study looks at whether taking cocoa extract or a daily multivitamin can reduce falls and improve physical performance in older adults. Over 21,000 men and women aged 60 and older are participating. Researchers are tracking falls that require medical care and repeated falls t…

This study looks at two kinds of plastic used in total knee replacement surgery: one with vitamin E and one without. The goal is to see which one lasts longer, causes less wear, and helps patients move better. About 605 adults with knee arthritis or similar problems took part, an…

This early-stage trial is testing a new stem cell treatment called HMM910 in 9 postmenopausal women with osteoporosis who are at high risk of breaking a bone. The stem cells are given through an IV drip. The main goal is to see if the treatment is safe and tolerable, not yet to p…

This study tests whether adding a daily supplement (vitamins D, K, C, magnesium, zinc, copper) to pulsed electromagnetic field therapy helps women aged 45-55 heal faster from a wrist fracture. Sixty women will either use the device alone or the device plus supplement for 30 days.…

This study tests a new surgical method that uses a tiny camera (endoscope) to repair broken facial bones through small, hidden cuts instead of large incisions. The goal is to see if this approach works as well as standard surgery while reducing scarring and nerve damage. Thirty a…

This study is following 202 people who received a special hip liner during hip replacement surgery. The goal is to see how long the liner lasts and whether it causes any problems over time. Participants are adults aged 18 to 80 with conditions like arthritis or hip fractures. The…

This study looks at 800 children with mild open fractures to see how much antibiotic is needed to prevent infections. Some kids get one dose, some get 24 hours, and some get 24 hours plus five days of pills. The goal is to find the best balance between preventing infection and av…

This study follows 200 adults who received the Medacta Shoulder System to treat shoulder problems like arthritis, fractures, or to replace a previous implant. Researchers are checking how long the implant lasts, how well the shoulder works, and any side effects. The goal is to co…

This study follows 100 people who need a hip replacement to see how long the MiniMAX hip stem lasts and how well it works. Participants receive the stem during surgery and are checked for implant survival and hip function using the Harris Hip Score. The goal is to confirm the ste…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study tests a program called PREVENT designed to reduce hip fractures in long-term care homes. The program uses a risk calculator based on residents' health records to identify those at high risk, then trains healthcare staff on the latest fracture prevention recommendations…

This study compares three care models to prevent falls and fractures in older adults recovering from a broken bone in a skilled nursing facility. About 3,780 participants across 42 facilities will receive either medication reduction, bone health management, or both. The goal is t…

This study tests a one-time nerve-freezing procedure called cryoneurolysis to treat pain from broken ribs. The treatment uses a small probe to freeze the nerves around the fractured ribs, providing pain relief for up to 2-3 months without the side effects or addiction risk of opi…

This study tests whether ketamine or lidocaine infusions can better manage pain from multiple broken ribs, reducing the need for opioids. About 74 adults with at least three broken ribs will receive one of the two medications for 72 hours. The goal is to improve breathing, reduce…

This study tests whether using virtual reality and action observation therapy during the time a wrist or hand is in a cast can improve recovery. Participants watch first-person videos of hand movements through a VR headset and then practice those movements. The goal is to prevent…

This pilot study tests whether robot-assisted gait training can improve walking in people with lower limb burns and fractures. Five participants will receive 30 minutes of robot training plus 30 minutes of conventional therapy daily for 8 weeks. The goal is to see if this combina…

This study aimed to compare two ways to manage pain from broken ribs: a continuous IV drip of lidocaine versus a nerve block called an erector spinae plane (ESP) block. The goal was to see which method reduces pain and improves breathing better. However, the study was withdrawn b…

This study tests whether a new type of screw (Bone Bolt) reduces pain better than standard screws after surgery for a specific pelvic fracture (LC-1). About 100 adults aged 18-80 will take part. The main goal is to see if the Bone Bolt leads to lower pain scores in the days after…

This study compares three types of local anesthesia for people with a broken wrist who need a fracture reduction in the emergency room. It aims to find which method—a nerve block, a hematoma block, or both—provides the best pain relief. About 105 adults will take part, and their …

This study tests whether adding suzetrigine to standard pain treatments helps adults with multiple broken ribs feel less pain and use fewer opioids. About 80 people will be randomly assigned to get either suzetrigine or a placebo alongside usual care. The goal is to improve breat…

This pilot study compares three pain relief methods for people with three or more broken ribs on one side. Participants will receive either a nerve block with a numbing medicine, a lidocaine infusion, or standard pain care. The goal is to see which approach reduces opioid use and…

This study examines whether people who donate a kidney have a higher long-term risk of breaking bones like the hip, wrist, or pelvis. Researchers will compare 50,000 living kidney donors from Canada to a matched group of healthy non-donors using health records from 1992 to 2024. …

This study looks back at 300 patients who had a hip replacement after a cancer-weakened bone broke. Researchers want to see how well patients walk, their pain levels, and how long they live compared to patients from decades ago. The goal is to find what helps people walk again af…

This registry will follow about 300 adults with orbital blow-out fractures to see how different treatments affect double vision and eye position over 6 months. Patients may receive surgery or non-surgical care as part of routine practice. The goal is to collect real-world data to…

This study aimed to see if using real-time ultrasound during a thoracic epidural block makes the procedure more reliable. It was designed for adults with chest or abdominal pain or rib fractures. The study was withdrawn before enrolling any participants, so no results are availab…

This study follows 70 adults aged 65 and older admitted to the hospital with an orthopedic injury. Researchers measure muscle strength, mobility, and thinking skills shortly after admission, again at day 7 or discharge, and 4-6 weeks after leaving the hospital. They also intervie…

This study looks at the medical records of over 550,000 athletes to understand how sports medicine services are used and how effective they are. The goal is to find ways to improve care and outcomes for people with sports injuries. No new treatments are being tested; instead, res…

This study tests whether sending information letters to doctors and patients after a fracture can improve osteoporosis care. Over 4,200 older adults in Manitoba who had a hip, spine, arm, or wrist fracture are included. The goal is to see if these notifications increase bone dens…

This study looks at how vitamin D and vitamin K interact to affect bone density and fracture risk in older adults. Researchers are analyzing data from over 25,000 participants who took vitamin D and omega-3 supplements or placebos. The goal is to see if people with low vitamin K …

This study is testing whether RNA molecules in the blood can predict if a broken bone will heal normally, slowly, or not at all. Researchers will collect blood samples from 110 people with fractures at several time points after injury and compare the RNA test results to actual he…

This study aimed to see if a web-based fracture liaison service (e-FLS) could help more older adults start osteoporosis treatment after a fracture compared to standard in-person services. It planned to include men and women over 60 in France who had a low-trauma fracture. However…

This study follows 200 adults who received the Medacta Shoulder System to treat various shoulder issues like arthritis, fractures, or rotator cuff problems. The main goal is to see how long the implant lasts and how well the shoulder works after surgery. It is a post-market check…

This registry follows 1,000 children with long bone fractures to see how different treatments (casts, surgery, or splints) affect healing. Doctors collect data on recovery, movement, and complications over two years. The goal is to learn which treatments work best for different f…