Vitamin e in knee implants: a Long-Term showdown
NCT ID NCT04618016
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at two kinds of plastic used in total knee replacement surgery: one with vitamin E and one without. The goal is to see which one lasts longer, causes less wear, and helps patients move better. About 605 adults with knee arthritis or similar problems took part, and they will be followed for many years to check how well their new knees work.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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605 people
The number who actually took part.
- Started
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Mar 2021
- Expected to finish
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Oct 2034
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
multicentric
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Indication for a total knee replacement with a mobile-bearing UC or PS inlay * Written informed consent for participating at the clinical study * Willingness and mental ability to participate at the long-term follow-up examinations Exclusion Criteria: * Patient age \< 18 and \> 80 years * Pregnancy * High risk patients (ASA class \>3)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Brüderhaus Koblenz
Koblenz, Rhineland-Palatinate, 56073, Germany
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CHU Amiens-Picardie
Amiens, 80054, France
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Hôpital Sud - CHU de Grenoble
Échirolles, Isere, 38130, France
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Krankenhaus Reinbek, St. Adolf Stift
Reinbek, 21465, Germany
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Lukas Krankenhaus
Bünde, North Rhine-Westphalia, 32257, Germany
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Park-Klinik Weißensee
Berlin, 13086, Germany
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Universitätsklinikum Rostock, Klinik für Orthopädie
Rostock, 18057, Germany
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Waldkliniken Eisenberg
Eisenberg, 07607, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a cementless hip stem hold up in asian patients?
- Can a special MRI match CT for spotting knee bone damage?
- Can a common bleeding drug make knee realignment surgery safer?
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- Three knee shots go Head-to-Head for lasting arthritis relief