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Can ketamine or lidocaine reduce opioid use for broken rib pain?

NCT ID NCT04781673

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether ketamine or lidocaine infusions can better manage pain from multiple broken ribs, reducing the need for opioids. About 74 adults with at least three broken ribs will receive one of the two medications for 72 hours. The goal is to improve breathing, reduce complications, and speed recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2021

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults ≥ 18 years old 2. ≥ 3 traumatic blunt rib fractures 3. Enrollment within 16 hours of being admitted to the hospital 4. Patients whom in the investigator's clinical judgement, would require escalated pain control regiments in the future and would potentially benefit from participation in this study in terms of pain control. Exclusion Criteria: 1. Patients receiving any regional/neuraxial anesthetic techniques or ketamine infusion before randomization 2. Adults with diminished decision-making capacity 3. Adults of limited English proficiency/non-English speakers 4. Prisoners 5. Pregnant or breastfeeding women 6. Patient admission weight greater than 120 kg 7. Patients with any of the following medical history: 1. Active delirium (as defined by Confusion Assessment Method) 2. Dementia 3. Psychosis 4. Glaucoma 5. Heart block (except with patients with a functioning artificial pacemaker) 6. Congestive heart failure (ejection fraction \<20% recorded in last year) 7. Adams-Stokes syndrome 8. Wolff-Parkinson-White Syndrome 8. Patient is unable to communicate with staff for pain assessments at time of enrollment 9. Most recent documented Glasgow Coma Score \<15 at the time of study enrollment 10. Severe bradycardia (heart rate \<50 bpm based on last vital sign recorded at time of study enrollment) 11. Sustained hypertension (systolic blood pressure \>180 mm Hg or diastolic blood pressure \>100 mm Hg for at least 3 sets of vital signs in a row prior to study enrollment) 12. Any seizure suspected or identified during hospital admission 13. Patient with active acute coronary syndrome obtained from admission problem list 14. Patients with known hepatic disease or acute liver failure a. Acute liver failure on admission defined as either: i. International normalized ratio \> 1.5, without being on home anticoagulation ii. Aspartate aminotransferase or Alanine aminotransferase greater than 120 IU/L (3 times upper limit of normal) b. Known hepatic disease defined as past medical history of Child Turcotte Pugh (Child's) score C 15. Patients with a history of end-stage renal disease or admission creatinine clearance (CrCl) ≤30 ml/min a. CrCl will be based on Cockcroft-Gault equation from admission labs 16. Use of antiarrhythmic medication therapy prior or during admission a. Amiodarone, sotalol, dofetilide, dronedarone, mexilitine 17. Patients with a known allergy/sensitivity to lidocaine or ketamine, amide anesthetics, or components of the solution 18. Patients who, in the investigator's opinion, should not be included in this study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Corewell Health West

    Grand Rapids, Michigan, 49503, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.