Bone fracture

Researchers are comparing two timings for flap surgery in adults with severe open fractures or dislocations below the knee. One group receives a flap within 72 hours of injury, while the other follows the standard timing used at each hospital. The trial measures death, amputation…

This trial tests whether a calcium-rich food chew, made from milk-derived minerals, is easier for women to take daily than a standard calcium carbonate pill. Women aged 40 to 90 at increased risk for osteoporosis will be randomly assigned to one of the two forms for four weeks. T…

This trial investigates whether applying vancomycin powder directly to open fracture wounds in the emergency department can reduce deep infections. Adults with open fractures are randomly assigned to receive either standard care or standard care plus a single dose of vancomycin p…

This study compares two common surgeries for broken hand bones: placing a small screw inside the bone versus using pins and a cast. About 100 adults with hand fractures will be randomly assigned to one of these treatments. The goal is to see which method helps people regain movem…

This study tests whether adding Platelet-Rich Fibrin (PRF) – a natural substance made from your own blood – to a bone graft helps the extraction site heal faster and grow more bone. Fourteen adults needing two tooth extractions will receive PRF plus bone graft in one socket and s…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study compares three common surgical techniques for fixing simple hand fractures: a screw, a plate, or pins. About 111 adults with fractures in the long fingers (excluding the thumb) will be randomly assigned to one method. The goal is to see which approach gives the best ha…

This study asks whether a simple ultrasound scan can safely and accurately track how well a child's broken bone is healing, compared with the standard X-ray. Children with fractures often need several X-rays during recovery, exposing them to small amounts of radiation. The trial …

This study tests whether a portable ultrasound device, used at the patient's bedside, can accurately diagnose long bone fractures in the emergency department. Adults with a suspected broken arm or leg will receive both an ultrasound and a standard X-ray. Researchers will compare …

This study looks at whether adding an ultrasound to a CT scan can find more rib cartilage fractures than a CT scan alone. Researchers will follow 100 adults with chest injuries to see if finding these hidden fractures changes treatment, such as whether surgery is needed. Particip…

This study tests whether an AI software called RBfracture helps clinicians better identify fractures, dislocations, and joint fluid buildup on X-rays. Sixteen doctors will review X-rays from 415 adult patients with and without the AI's help. The goal is to see if the AI improves …

After surgery for a broken finger bone, scar tissue can form around tendons and make the finger stiff. Researchers are testing whether injecting a small amount of the patient's own fat around the repaired bone or during scar-release surgery helps the finger move better. In this d…

This study tests whether using a small vibration tool after wrist fracture surgery can reduce pain and the need for opioid painkillers. One hundred adults who have had surgery for a broken wrist will be randomly assigned to use the vibration tool or not. Researchers will measure …

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study tests whether special dissolving nails can heal children's broken forearm bones as well as standard titanium nails. The dissolving nails go away on their own, so many kids might not need a second operation to remove them. About 60 children who need surgery for a displa…

This study looks at whether a nerve block called a serratus plane block can help people with multiple broken ribs breathe better and feel less pain. 72 adults with at least two broken ribs on one side will be split into three groups: standard painkillers alone, standard painkille…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests a new, non-invasive chest stabilizer for people with multiple rib fractures from blunt chest trauma. The device is worn for 10 days and aims to reduce pain, improve breathing, and prevent lung complications like pneumonia. Researchers will compare it to standard …

Researchers at Assiut University Hospitals are reviewing medical records of patients treated for facial fractures between January 2025 and December 2028. The study aims to describe who gets these injuries, what caused them, which bones break, and how patients fare. By analyzing e…

This study will track outcomes for 100,000 patients undergoing surgery in 1,000 hospitals across 100 countries. The goal is to understand how post-operative complications vary worldwide and what factors—like hospital resources—might influence them. By comparing results across inc…

This study compares two methods—mixed reality goggles and ultrasound—to help surgeons mark exactly where ribs are broken before surgery. About 30 adults with three or more broken ribs will take part. The goal is to see which method is more accurate and faster.

This observational study aims to build and test models that predict risks like delirium and death after fracture surgery in older adults. Researchers will collect data on pain, sleep quality, and brain activity to see how these factors relate to short- and long-term outcomes. The…

This study watches 250 adults with broken leg or pelvis bones to see who develops hemorrhagic shock — a dangerous drop in blood pressure from blood loss. Researchers want to know which fractures are most likely to cause this emergency. The goal is to help doctors quickly spot and…

This study investigates why some people who have surgery for broken bones go on to develop long-term pain. Researchers are collecting blood samples and information on medical, psychological, and social factors from 600 adult patients. The goal is to create a model that can predic…

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…

This study looks at 100 elderly patients with hip fractures to see if quick, easy tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors provide sa…

This observational study from the University of Nottingham aims to find out which factors predict chronic pain after a serious limb injury. Researchers will follow 450 major trauma patients with at least one broken limb for 6 months, asking them about their pain at 3 and 6 months…

This study will follow 100 adults aged 65 and older who have a broken shoulder (proximal humerus fracture). Some will receive surgery (plates, screws, or a shoulder replacement) and others will be treated without surgery. Researchers will measure shoulder movement, pain, and dail…

This study will look back at the medical records of about 2000 older adults (60+) who had surgery for a broken bone in Shanghai between 2010 and 2019. Researchers want to see how factors like age, nutrition, and which bone broke affect the risk of dying within 1, 3, or 5 years af…