Bacterial infectious disease with sepsis

This study tests whether stable patients with a common blood infection (gram-negative bacteraemia) can safely switch from IV antibiotics to oral pills within 72 hours. Researchers will compare early oral therapy to continued IV treatment in 720 adults. The main goal is to see if …

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tested a new medicine called AP-SA02, given through a vein, along with standard antibiotics for adults with a Staph blood infection. The main goal was to check if the combination is safe and tolerable. Researchers also looked at whether it helped clear the infection fa…

This study tested a rapid blood test (T2Bacteria Panel) that identifies bacteria directly from blood, compared to standard blood cultures that take 1-3 days. Researchers wanted to see if using this test could help doctors stop unnecessary vancomycin (a strong antibiotic) sooner i…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This study tested a lab-made antibody called 514G3 in 52 hospitalized adults with Staphylococcus aureus bloodstream infections. Participants received either a single dose of the antibody plus standard antibiotics or a placebo plus antibiotics. The main goals were to check safety …

This study tested whether an older antibiotic, temocillin, works as well as the standard treatment meropenem for bloodstream infections caused by drug-resistant bacteria. 334 adults with these infections were randomly assigned to receive one of the two antibiotics for 7 to 14 day…

This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentia…

This trial tests whether a rapid diagnostic test called Reveal can improve outcomes for hospitalized patients with gram-negative bloodstream infections. The test measures bacterial growth by detecting gases they release, giving results in about 5 hours instead of the usual 2-3 da…

This study tested a new rapid test (OCEAN Dx) to identify bacteria in the blood of 110 ICU patients with suspected sepsis. The goal was to see if it works as well as standard blood cultures, which take 48-72 hours. A faster result could help doctors choose the right antibiotics s…

This study tests whether a special antimicrobial dressing can reduce bloodstream infections from central venous catheters in children in intensive care. About 250 children will be randomly assigned to receive either the antimicrobial dressing or a standard one. The main goal is t…

This study tested whether three new diagnostic tools could help doctors pick the best antibiotic faster for ICU patients with Gram-negative bloodstream infections. Researchers compared standard lab methods to the new tests in 100 patients. The goal was to see if more patients got…

This study looks at whether emergency medicine pharmacists can review positive blood culture results faster after patients leave the emergency department. Delays in notifying patients about serious infections can lead to sepsis or death. The trial will compare how quickly pharmac…

This study looked at 102 patients with bloodstream infections to compare standard lab cultures with two new rapid detection methods. The goal was to see how long germs stay in the blood and whether the new tests can give faster, more accurate results. This information could help …

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study looked at 232 adult cancer patients with sepsis and low blood pressure to see if adding a type of antibiotic called aminoglycosides helps them recover faster. The main goal was to see how quickly their blood pressure returned to normal without needing strong blood pres…

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find which toxins (harmful substances) the bacteria produce that lead to serious illnesses like blood infections or heart valve infections. Researchers compared samples from patients with differen…

This study looked at 1,529 intensive care patients with sepsis to see if a blood marker called procalcitonin (PCT) can help identify the type of bacteria causing the infection. Researchers measured PCT levels within 24 hours of a positive blood culture. The goal was to see if PCT…

This study tested whether having a study team call doctors with a checklist could improve how they manage patients with Staphylococcus aureus bloodstream infections. The calls reminded doctors of key steps like follow-up blood cultures, proper antibiotics, and imaging tests. The …

This completed study looked at 314 ICU patients with bloodstream infections caused by Enterobacterales bacteria. Researchers identified how often these bacteria were resistant to common antibiotics and what patient factors increased the risk. The goal was to understand resistance…

This study looked at 350 patients who had surgery (decortication) to treat severe lung infections called empyema, including cases caused by tuberculosis and drug-resistant bacteria. The goal was to understand the types of germs causing these infections and how they affect recover…