Acquired aneurysmal subarachnoid hemorrhage

This study looks at whether starting insulin to lower high blood sugar on day 4 after a severe stroke is better than starting on day 1. About 200 adults with severe stroke and high blood sugar will be randomly assigned to early or delayed treatment. The goal is to see if delaying…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can reduce harmful spasms in brain arteries that often occur days after an aneurysm rupture. The study will enroll 10 adults who have had this type of bleeding in the brain and will rec…

This trial investigates the safety and effectiveness of using a stent along with coil embolization to treat ruptured brain aneurysms. The procedure is performed within a week of the bleeding event in patients aged 18 to 80 with wide-neck aneurysms. Researchers are monitoring for …

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospi…

This study is tracking how well a device called NeVa VS works to open narrowed brain arteries in people who had a bleeding aneurysm. The device is already approved for this use, and researchers want to see how it performs in routine care. About 200 adults will be followed to meas…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This study looks at a new way to treat severe brain bleeds caused by aneurysms. Instead of coiling the whole aneurysm, doctors will only coil the dome (the bulging part). The goal is to see if this lowers the risk of re-bleeding and improves recovery. The study will enroll 30 adu…

This study tests whether giving dornase alfa (a drug already used for cystic fibrosis) daily for up to 14 days after a brain bleed from a ruptured aneurysm can help people recover better. The goal is to see if more patients can live independently at 6 months. The trial will enrol…

This study tests whether starting lumbar drainage and injecting the clot-busting drug urokinase early after a severe brain bleed improves patients' recovery. About 424 adults with a first-time severe aneurysmal subarachnoid hemorrhage will be randomly assigned to get either the a…

This study tests whether a small, handheld device that gently stimulates a nerve in the ear (tVNS) is safe and practical for people recovering from a brain bleed (aneurysmal subarachnoid haemorrhage). About 30 participants will receive either the real stimulation or a dummy versi…

This study tests a drug called tocilizumab-aazg in 30 adults who have had a burst brain aneurysm. The goal is to see if the drug is safe and might help prevent strokes that can happen after the bleeding. Participants will receive the drug within 24 hours of the aneurysm rupture a…

This study tests whether a steroid pill called fludrocortisone can reduce death and disability in people who have had a brain bleed from a burst aneurysm. The trial will enroll 524 critically ill adults who have had their aneurysm secured. Half will receive the drug, half a place…

This Phase 2 trial tests whether deferoxamine, a drug that binds excess iron, can reduce brain injury after aneurysmal subarachnoid hemorrhage (aSAH), a severe stroke with high death and disability rates. About 120 participants will receive one of two doses of deferoxamine or a p…

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a brain bleed from a burst aneurysm. The treatment involves briefly inflating a blood pressure cuff on a limb to improve blood flow and reduce brain damage. Researc…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…

This study tests whether injecting the drug nicardipine into the spinal fluid can improve recovery in people who develop blood vessel spasms after a brain aneurysm bleed. About 396 adults aged 18–80 will receive either the drug or a sham procedure. The goal is to see if the treat…

This study is testing whether machine learning and special brain injury markers in blood and spinal fluid can warn doctors early when a patient with a brain bleed is developing delayed cerebral ischemia (lack of oxygen to the brain). Researchers will monitor 1,500 adults in inten…

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults …

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study tests whether early training that combines thinking tasks with physical movement can help people recover cognitive and motor skills after a brain aneurysm bleed. The training is done 4-5 times a week for 30 minutes while in the hospital. Researchers will measure memory…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether a scalp block (a numbing injection) can reduce severe headaches in patients who have had a brain aneurysm rupture. About 22 adults in intensive care will receive either standard care plus the scalp block or standard care alone. The goal is to see if the b…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

This study looks at whether people who have had a ruptured brain aneurysm also have an abdominal aortic aneurysm (a bulge in the main belly artery) that they don't know about. About 233 participants will get a painless belly ultrasound to check. The goal is to see how common this…

This study looks at whether levels of nitric oxide in spinal fluid can predict dangerous blood vessel spasms after a type of brain bleed called subarachnoid hemorrhage. Researchers will compare nitric oxide levels in 40 patients with and without this condition. The goal is to fin…

This study is tracking 5,000 people who had a brain bleed from a ruptured aneurysm. Researchers are collecting medical data to find factors that predict complications like delayed brain injury or long-term disability. The goal is to create a computer model that helps doctors fore…

This study is looking at 160 people who had a ruptured brain aneurysm and need a temporary drain. Researchers will measure glucose in their spinal fluid and blood daily for up to 14 days. The goal is to see if higher glucose levels are linked to needing a permanent shunt later. P…

This observational study looks at proteins in tiny particles called extracellular vesicles from the blood of 120 people with brain aneurysms. Researchers will collect blood from different areas of the circulatory system during surgery to compare protein patterns. The goal is to f…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study tracks 500 adults in Canada and the US who have had a brain aneurysm bleed and are taking the drug nimodipine. Researchers will measure how much of the drug gets into each patient's blood and see how that relates to their recovery 90 days later. The goal is to understa…

This study is collecting information from 1,000 people who have been treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real life, not just in controlled trials. No new treatments are being tested—just data gathe…

This study follows 10,000 patients who had a bleeding aneurysm in the brain to learn more about a complication called delayed ischemic neurological deficit (DIND). Researchers will track how doctors diagnose and treat DIND, and compare different treatment approaches to see which …

This study observes 200 adults who had a bleeding stroke from a brain aneurysm and now have narrowed blood vessels. Researchers will monitor brain blood flow using ultrasound to see how it changes with standard treatments like raising blood pressure or using medication to widen v…

This study looks at how much of the antibiotic telavancin gets into the brain fluid of 20 critically ill patients who have a drain in their head (external ventricular drain). These patients often need strong antibiotics, but it's not clear if telavancin reaches the brain well eno…

This study enrolls 2,000 adults who had a brain bleed from a ruptured aneurysm. Researchers will collect blood, spinal fluid, urine, and stool samples to analyze genes, proteins, and other molecules. The goal is to understand why some patients develop serious complications like d…

This study examines whether memory problems after a type of brain bleed (aneurysmal subarachnoid hemorrhage) are linked to a smaller hippocampus, a brain area key for memory. Researchers will compare 30 patients in rehabilitation with healthy volunteers using memory tests and MRI…