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Could a common steroid help brain bleed survivors walk again?

NCT ID NCT06409364

Disease control Sponsor: The George Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a steroid pill called fludrocortisone can reduce death and disability in people who have had a brain bleed from a burst aneurysm. The trial will enroll 524 critically ill adults who have had their aneurysm secured. Half will receive the drug, half a placebo, and researchers will measure how independent they are six months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fludrocortisone (a steroid hormone pill)
What this could lead to
If it works, this could offer a simple, cheap treatment to improve recovery and reduce long-term disability after a brain bleed from a burst aneurysm.
What could go wrong
This is a mid-stage trial, so results are not guaranteed. The drug may not improve outcomes, and steroids can have side effects like infection or electrolyte imbalance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 524 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 years or older 2. Diagnosed with subarachnoid haemorrhage from an aneurysm confirmed on computed tomography angiography (CTA) or digital subtraction angiography (DSA) of the intra-cranial arteries 3. Aneurysm has been secured 4. Hospital admission for aSAH within 96 hours 5. Currently being treated in a critical care environment Exclusion Criteria: 1. Unable to receive enteral medications 2. Pre-existing glucocorticoid or mineralocorticoid treatment 3. Previous allergic reaction to fludrocortisone 4. History of cardiac, hepatic, or renal failure 5. Hypernatremia or hyponatremia (Na\>145mmol/L or Na\<125mmol/L) on the most recent blood sample at the time of screening. 6. Death deemed imminent or inevitable 7. Pregnancy (confirmed or suspected) 8. Previous inclusion in the FLASH trial

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aneurysmal subarachnoid hemorrhage

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    16 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Auckland City Hospital

    NOT_YET_RECRUITING

    Auckland, 1023, New Zealand

  • Gold Coast University Hospital

    RECRUITING

    Gold Coast, Queensland, 4215, Australia

  • John Hunter Hospital

    NOT_YET_RECRUITING

    New Lambton Heights, New South Wales, 2042, Australia

  • Monash Medical Centre

    NOT_YET_RECRUITING

    Clayton, Victoria, 3168, Australia

  • Nepean Hospital

    RECRUITING

    Penrith, New South Wales, 2747, Australia

  • Prince of Wales Hospital

    NOT_YET_RECRUITING

    Randwick, New South Wales, 2031, Australia

  • Princess Alexandra Hospital

    NOT_YET_RECRUITING

    Woolloongabba, Queensland, 4102, Australia

  • Royal Brisbane Women's Hospital

    NOT_YET_RECRUITING

    Brisbane, Queensland, 4029, Australia

  • Royal Hobart Hospital

    NOT_YET_RECRUITING

    Hobart, Tasmania, 7000, Australia

  • Royal North Shore Hospital

    NOT_YET_RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • St Vincent's Hospital (Melbourne)

    NOT_YET_RECRUITING

    Fitzroy, Victoria, 3065, Australia

  • The Alfred Hospital

    NOT_YET_RECRUITING

    Melbourne, Victoria, 3044, Australia

  • Townsville Hospital

    NOT_YET_RECRUITING

    Townsville, Queensland, 4814, Australia

  • Wellington Hospital

    NOT_YET_RECRUITING

    Wellington, 6011, New Zealand

  • Westmead Hospital

    NOT_YET_RECRUITING

    Westmead, New South Wales, 2145, Australia

  • Wollongong Hospital

    NOT_YET_RECRUITING

    Wollongong, New South Wales, 2521, Australia

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