New combo aims to tame immunotherapy side effects in advanced cancers

NCT ID NCT04940299

First seen Oct 31, 2025 · Last updated May 12, 2026 · Updated 23 times

Summary

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe side effects in people with advanced melanoma, lung, or bladder cancer. About 35 participants will receive the combination to see if it is safer and still effective. The goal is to make powerful cancer treatments more tolerable.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE III CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8 LOCALLY ADVANCED BLADDER CARCINOMA LOCALLY ADVANCED BLADDER UROTHELIAL CARCINOMA LOCALLY ADVANCED LUNG NON-SMALL CELL CARCINOMA LOCALLY ADVANCED RENAL PELVIS CARCINOMA LOCALLY ADVANCED RENAL PELVIS UROTHELIAL CARCINOMA LOCALLY ADVANCED URETER UROTHELIAL CARCINOMA LOCALLY ADVANCED URETHRAL UROTHELIAL CARCINOMA MALIGNANT SOLID NEOPLASM METASTATIC BLADDER CARCINOMA METASTATIC BLADDER UROTHELIAL CARCINOMA METASTATIC LUNG NON-SMALL CELL CARCINOMA METASTATIC MELANOMA METASTATIC RENAL PELVIS UROTHELIAL CARCINOMA METASTATIC URETER UROTHELIAL CARCINOMA METASTATIC URETHRAL CARCINOMA METASTATIC URETHRAL UROTHELIAL CARCINOMA PATHOLOGIC STAGE III CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE III CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IIIA CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IIIA CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IIIB CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IIIC CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IIID CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8 PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8 STAGE III BLADDER CANCER AJCC V8 STAGE III BLADDER CANCER AJCC V8 STAGE III LUNG CANCER AJCC V8 STAGE III LUNG CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE IIIA BLADDER CANCER AJCC V8 STAGE IIIA BLADDER CANCER AJCC V8 STAGE IIIA LUNG CANCER AJCC V8 STAGE IIIA LUNG CANCER AJCC V8 STAGE IIIB BLADDER CANCER AJCC V8 STAGE IIIB BLADDER CANCER AJCC V8 STAGE IIIB LUNG CANCER AJCC V8 STAGE IIIB LUNG CANCER AJCC V8 STAGE IIIC LUNG CANCER AJCC V8 STAGE IIIC LUNG CANCER AJCC V8 STAGE IV BLADDER CANCER AJCC V8 STAGE IV LUNG CANCER AJCC V6 STAGE IV LUNG CANCER AJCC V6 STAGE IV RENAL PELVIS CANCER AJCC V8 STAGE IV RENAL PELVIS CANCER AJCC V8 STAGE IV URETER CANCER AJCC V8 STAGE IV URETER CANCER AJCC V8 STAGE IV URETHRAL CANCER AJCC V8 STAGE IV URETHRAL CANCER AJCC V8 STAGE IVA LUNG CANCER AJCC V8 STAGE IVA LUNG CANCER AJCC V8 STAGE IVB LUNG CANCER AJCC V8 STAGE IVB LUNG CANCER AJCC V8 UNRESECTABLE MELANOMA