STAGE IVA LUNG CANCER AJCC V8

This early-phase trial is testing a combination of two drugs, osimertinib and tegavivint, as the first treatment for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC that has spread). The main goal is to find the safest and most effective dose. About 24 adul…

This study tests a combination of two drugs—temozolomide (chemotherapy) and atezolizumab (immunotherapy)—for people with small cell lung cancer that has spread or returned after initial treatment. The goal is to see if this combination can shrink tumors and help patients live lon…

This early-stage trial tests a new drug (PBF-1129) combined with an immunotherapy (nivolumab) in 30 adults with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand side effects. Participants must have already tr…

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps control t…

This study tests a drug called avapritinib in people with advanced solid tumors that have certain genetic changes (CKIT or PDGFRA mutations). The goal is to see if the drug can shrink or control the cancer. About 50 adults with cancers like melanoma, sarcoma, or breast, lung, or …

This early-stage trial tests a new drug (MRX-2843) combined with a standard treatment (osimertinib) for people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest and most effective dose and to see how well the combination works. About 69 particip…

This early study tests a combination of two immune-boosting drugs, low-dose IL-2 and pembrolizumab, in 15 people with advanced (stage IV) non-small cell lung cancer who have not had prior treatment. The goal is to see if the combo can reinvigorate tired immune cells to better att…

This study tests a special dye that attaches to lung cancer cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove all cancer, including tiny spots that might otherwise be missed. About 30 adults with lung cancer or lung metastases wi…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, as well as for their family caregivers. About 400 patient-caregiver pairs will take part…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…