Promising drug combo targets Hard-to-Treat bone cancer

NCT ID NCT05830084

First seen Jan 08, 2026 · Last updated Jun 14, 2026 · Updated 21 times

Summary

This early-phase trial tests whether adding the targeted drug regorafenib to standard chemotherapy is safe for people with newly diagnosed, widespread Ewing sarcoma. The study includes 23 patients aged 2 to 49 whose cancer has spread beyond the lungs. The main goal is to find the right dose and check for serious side effects.

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Contacts and locations

Locations

  • CHU Bordeaux

    Bordeaux, France

  • Centre Oscar Lambret

    Lille, France

  • Gustave Roussy

    Villejuif, Île-de-France Region, 94805, France

  • Institut Curie

    Paris, France

  • Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Monash Children's Hospital

    Clayton, Australia

  • Perth Children's Hospital

    Perth, WA6009, Australia

  • Princess Máxima Center

    Utrecht, 113, Netherlands

  • Queensland Children's Hospital

    Brisbane, Australia

  • Rigshospitalet

    Copenhagen, DK-2100, Denmark

  • Royal Children's Hospital

    Parkville, Australia

  • Vall d'Hebron University Hospital

    Barcelona, 119-12, Spain

  • centre Léon Bérard

    Lyon, France

Conditions

Explore the condition pages connected to this study.