New hope for tough cancers: experimental drug targets treatment resistance

NCT ID NCT03678883

Ongoing Disease control Sponsor: Actuate Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Apr 10, 2026 · Last updated Apr 16, 2026 · Updated 1 time

Summary

This study is testing a new drug called 9-ING-41, which is designed to block a protein that helps cancer cells survive and resist chemotherapy. It is for adults with advanced or metastatic cancers, including pancreatic, breast, and lung cancers, that have worsened despite standard treatments. The research aims to find safe doses and see if the drug, given alone or with common chemotherapies, can help control these difficult cancers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Allegheny Health Network

Pittsburgh, Pennsylvania, 15212, United States
Arizona Oncology Associates

Tucson, Arizona, 85704, United States
Baptist Clinical Research Institute

Memphis, Tennessee, 38120, United States
CHRU Brest Hopital Morvan

Brest, Brittany Region, 29200, France
Capital Health Medical Center/ Hopewell

Pennington, New Jersey, 08534, United States
Center Hospitalier Regional Universitaire de Besancon - Site Jean Minjoz

Besançon, Bourgogne-Franche-Comté, 25030, France
Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre

Greenfield Park, Quebec, G4V 2H1, Canada
Centro Hospitalar Universitario Sao Joao

Porto, 4200-319, Portugal
Christiana Care Health Services

Newark, Delaware, 19709, United States
Columbia University- Irving Medical Center

New York, New York, 10032, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89128, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Des Moines Oncology Research Association

Des Moines, Iowa, 50309, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Florida Cancer Specialists - North

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists - South

Fort Myers, Florida, 33901, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Fundacao Champalimaud

Lisbon, 1400-038, Portugal
Hopital Claude Huriez

Lille, Hauts-de-France, 59037, France
Hopital de la Timone

Marseille, 13005, France
Hospital Clinico U San Carlos (HSC)

Madrid, 28050, Spain
Hospital Da Luz

Lisbon, 1500-650, Portugal
INCLIVA University of Valencia

Valencia, 46010, Spain
Imelda VZW

Bonheiden, 2820, Belgium
Insitut de Cancerologie de l'Ouest

Saint-Herblain, Pays de la Loire Region, 44800, France
Institut Bergonie

Bordeaux, Nouvelle-Aquitaine, 33076, France
Institut Catala d'Oncologia

Barcelona, 8908, Spain
Institute de Cancerologie de Lorraine

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Kansas University Cancer Center

Kansas City, Kansas, 66160, United States
MD Anderson Cancer Center at Cooper

Voorhees Township, New Jersey, 08043, United States
Mayo Clinic

Phoenix, Arizona, 85054, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
McGill University Health Centre

Montreal, Quebec, H4A 3J1, Canada
MetroMetro-Minnesota Community Oncology Research Consortium (MMCORC)

Minneapolis, Minnesota, 55416, United States
Miami Cancer Institute

Miami, Florida, 33176, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Netherlands Cancer Institute

Amsterdam, 1066 CX, Netherlands
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Prisma Health Cancer Institute

Greenville, South Carolina, 26905, United States
QE II Health Sciences Centre

Halifax, Nova Scotia, B3H 2Y9, Canada
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Chicago, Illinois, 60611, United States
START Madrid-HM CIOCC Hospital Universitario

Madrid, 28050, Spain
Sanford Research

Sioux Falls, South Dakota, 57105, United States
Sarah Cannon Research Institute- Tennessee Oncology-Nashville

Nashville, Tennessee, 37203, United States
Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States
St. Luke's University Health Network

Bethlehem, Pennsylvania, 18015, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
Texas Oncology- Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
The University of Arizona Cancer Center

Tucson, Arizona, 85719, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94115, United States
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
UW Carbone Cancer Center

Madison, Wisconsin, 53792, United States
UZ Gent

Ghent, 9000, Belgium
UZ Leuven Gasthuisberg

Leuven, 3000, Belgium
UZA- Antwerpen

Edegem, Antwerp, 2650, Belgium
University of California Irvine Health

Orange, California, 92868, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
Utah Cancer Specialists

Salt Lake City, Utah, 84124, United States
Vall d'Hebron Institute of Oncology

Barcelona, 08035, Spain
Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, 37232, United States
West Cancer Center

Germantown, Tennessee, 38138, United States
West Virginia University

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

ACUTE T CELL LEUKEMIA LYMPHOMA BONE CANCER BONE METASTASES BONE NEOPLASM BREAST NEOPLASMS CANCER MALIGNANCIES MALIGNANCIES MULTIPLE MALIGNANT GLIOMA NEOPLASM METASTASIS NEOPLASM OF BONE NEOPLASM OF LUNG NEOPLASM, BREAST NEOPLASMS PANCREATIC NEOPLASMS, COLORECTAL PANCREAS CANCER PANCREATIC ADENOCARCINOMA PANCREATIC CANCER PANCREATIC NEOPLASMS REFRACTORY CANCER REFRACTORY NEOPLASM REFRACTORY NON-HODGKIN LYMPHOMA RENAL CANCER RESISTANT CANCER SARCOMA