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Can better anesthesia save older minds after hip surgery?

NCT ID NCT06452147

Prevention Sponsor: Second Affiliated Hospital of Wenzhou Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Older adults who break a hip often face surgery, and some develop confusion or memory problems afterward. This trial tests whether improved anesthesia methods, such as a nerve block before surgery or an intravenous lidocaine drip, can lower the risk of these cognitive issues compared with standard anesthesia. The study enrolls people aged 65 and older with a hip fracture and also includes a group who do not have surgery to help understand normal cognitive changes. Researchers will measure thinking and memory in the first week after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A preoperative regional nerve block and perioperative intravenous lidocaine infusion, compared with standard anesthesia care
What this could lead to
If enhanced anesthesia techniques work, they could become a standard way to protect thinking and memory in older adults after hip fracture surgery.
What could go wrong
The trial may find that these techniques do not reduce cognitive problems, or the benefits may be too small to justify changing practice. Nerve blocks and lidocaine carry small risks like bleeding, infection, or allergic reaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,860 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 65 years and older. 2. Patients with unilateral hip fracture (including femoral neck, femoral head, intertrochanteric and subtrochanteric fractures) are scheduled for surgical treatment. 3. American Society of Anesthesiologists (ASA) physical status IV or below. 4. The patients or family members provide written informed consent. 5. Additional inclusion criteria may pertain to specific interventions and will be described in relevant sub-protocols. Exclusion Criteria: 1. Patients with multiple trauma or fractures (excluding trauma that the researcher judges will not affect the patient's overall recovery, such as simple spinal compression fractures, mild soft tissue contusions, fractures of hands and feet, etc.); 2. Two or more anesthetic surgeries are required. 3. Patients with an obvious history of head trauma (such as loss of consciousness for more than 5 minutes, post-traumatic amnesia, etc.); 4. Patients who the researcher believes are unable to complete the assessment of primary outcome; 5. Additional exclusion criteria may pertain to specific interventions and will be described in relevant sub-protocols. Additional exclusion criteria for the nerve block randomization: 1. Contraindications to nerve block, including allergy to local anesthetics, other contraindications specified in the applicable prescribing information, infection at the puncture site, or refusal to receive nerve block; 2. The investigator considers the participant unsuitable for nerve block because of conditions such as a history of severe peripheral neuropathy or severe coagulation dysfunction; 3. Receipt of nerve block before randomization during the current hospitalization. Additional exclusion criteria for the intravenous lidocaine randomization: 1. Allergy to lidocaine; 2. Severe hepatic impairment or renal insufficiency for which the investigator considers the participant unsuitable for enrollment. Eligibility Criteria for nonsurgical cognitive control participants: A nonsurgical cognitive control cohort may be recruited from emergency departments, outpatient clinics, inpatient wards, or the community for standardization of neurocognitive assessments. These participants will be matched as far as possible to surgical participants by age and education level. Except for criteria related to hip fracture surgery and trial interventions, the same general inclusion and exclusion criteria will apply. Nonsurgical cognitive control participants must not undergo surgery or anesthesia during the observation period; participants who undergo surgery during follow-up will be excluded from the nonsurgical cognitive control cohort.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction dementia hip fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Cognitive decline Cognitive impairment Dementia Hip fractures

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    13 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dongyang People's Hospital

    ENROLLING_BY_INVITATION

    Dongyang, Zhejiang, China

  • Jinhua Municipal Central Hospital

    RECRUITING

    Jinhua, Zhejiang, China

  • Lishui Central Hospital, the Fifth Hospital Affiliated to Wenzhou Medical University

    RECRUITING

    Lishui, Zhejiang, China

  • Lishui People's Hospital

    RECRUITING

    Lishui, Zhejiang, China

  • Ningbo No.2 Hospital

    RECRUITING

    Ningbo, Zhejiang, China

  • Ningbo No.6 Hospital

    RECRUITING

    Ningbo, Zhejiang, China

  • Quzhou People's Hospital

    RECRUITING

    Quzhou, Zhejiang, China

  • Taizhou Central Hospital

    ENROLLING_BY_INVITATION

    Taizhou, Zhejiang, China

  • The First Affiliated Hospital of Wenzhou Medical University

    ENROLLING_BY_INVITATION

    Wenzhou, Zhejiang, 325000, China

  • The First People's Hospital of Wenling

    RECRUITING

    Wenling, Zhejiang, China

  • The Second Affilliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, Zhejiang, 325000, China

  • Zhejiang Provincial People's Hospital

    ENROLLING_BY_INVITATION

    Hangzhou, Zhejiang, China

  • Zhejiang Taizhou Hospital

    ENROLLING_BY_INVITATION

    Taizhou, Zhejiang, China

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