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Half the anesthetic, same pain relief? trial tests lower bupivacaine dose for gallbladder surgery

NCT ID NCT07841951

Symptom relief Sponsor: Medipol University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Laparoscopic gallbladder removal is minimally invasive, but patients often wake up with significant pain. Researchers are testing a nerve block that injects bupivacaine between the abdominal muscles and ribs to numb the nerves that carry pain from the surgical area. The trial compares two strengths of bupivacaine, 0.25% and 0.125%, against standard pain management with numbing at the incision sites. Ninety adults scheduled for elective gallbladder surgery will be randomly assigned to one of the three groups. The main question is whether the lower concentration controls pain just as well while using half the total drug dose, which could reduce the risk of rare but serious anesthetic toxicity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine, a local anesthetic injected around abdominal nerves during gallbladder surgery
What this could lead to
If the lower concentration works as well, doctors could use half the drug and cut the risk of local anesthetic toxicity during this common operation.
What could go wrong
The weaker dose may not control pain as well, leaving patients needing more rescue opioids. This is a single-center study of 90 people, so results may not apply everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled for elective laparoscopic cholecystectomy under general anesthesia * Aged between 18 and 65 years * American Society of Anesthesiologists (ASA) physical status I or II * Body weight above 60 kg * Able and willing to provide written informed consent Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics or opioids * Coagulopathy or ongoing anticoagulant therapy * Infection at the site of block injection * Alcohol or substance dependence, or chronic opioid use * Pregnancy or lactation * Advanced hepatic or renal failure * Any condition preventing the participant from understanding and using the - numeric rating scale * Refusal to participate

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Conditions

The condition(s) this trial relates to.

Acute Pain cholelithiasis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Anesthesia Cholelithiasis Postoperative pain

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Istanbul Medipol University Mega Hospital Complex, Department of Anesthesiology and Reanimation

    Istanbul, Turkey (Türkiye)

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