Non-Opioid pain drug tested against standard analgesia for skin cancer surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Biopsy-proven cutaneous malignancy of the head or neck, including melanoma, melanoma in situ, cutaneous squamous cell carcinoma, or basal cell carcinoma, or a biopsy-confirmed precursor lesion to skin cancer requiring excision * Planned treatment by Mohs micrographic surgery or wide local excision * Surgical defect requiring intermediate layered closure, complex closure, adjacent tissue transfer, or full-thickness skin graft * Able to take oral medications * Access to an electronic diary device, or willingness to use a paper backup * Able to provide written informed consent, with English, Hmong, or Somali language materials and interpreter support available Exclusion Criteria: * Contraindication to ibuprofen, including active peptic ulcer disease, history of gastrointestinal bleeding, estimated glomerular filtration rate below 30 mL/min/1.73 m², or NSAID hypersensitivity * Moderate or severe hepatic impairment, defined as Child-Pugh Class B or C * Chronic heavy alcohol use * Known hypersensitivity to acetaminophen * Known hypersensitivity to opioids * Severe untreated obstructive sleep apnea or other respiratory compromise that would make a short course of breakthrough oxycodone unsafe * Concurrent use of a benzodiazepine or other sedative-hypnotic * Concurrent use of a strong or moderate CYP3A inhibitor, or a strong or moderate CYP3A inducer * Regular opioid use in the prior 30 days, meaning opioid use on most days or any standing opioid prescription * Body weight below 50 kg * Prior major bleeding on a nonsteroidal anti-inflammatory drug, or an active bleeding disorder * Pregnancy or breastfeeding * Prior adverse reaction to suzetrigine * Cognitive impairment precluding completion of patient-reported outcomes * Participation in another interventional trial within 30 days * Children * Fetuses * Neonates * Prisoners * Adults lacking capacity to consent or adults with diminished or fluctuating capacity to consent * Employees of the researcher * Students of the researcher * Individuals approached in emergency or acutely stressful settings