Xijing Hospital Of Digestive Diseases

This study is for adults with primary biliary cholangitis (PBC) and compensated cirrhosis who still have high alkaline phosphatase levels despite taking ursodeoxycholic acid (UDCA). Researchers want to see if adding fenofibrate to UDCA can normalize liver enzyme levels and improv…

This study tests if fenofibrate can improve liver function in adults with primary biliary cholangitis (PBC) who haven't been treated before. About 132 participants will take either fenofibrate or the standard drug UDCA daily for 12 months. The goal is to see which drug better nor…

This study is testing the long-term safety of combining two drugs, fenofibrate and ursodeoxycholic acid, for people with primary biliary cholangitis (PBC), a chronic liver disease. About 300 adults who have already completed a related PBC study will take the combination and be mo…

This study tests whether upadacitinib works as well as infliximab for people with a severe flare of ulcerative colitis who didn't get better with first-line treatment. About 226 adults will be randomly assigned to one of the two drugs and followed for 3 months. The goal is to see…

This study looks at the long-term safety of taking fenofibrate together with ursodeoxycholic acid for people with primary biliary cholangitis (PBC), a chronic liver disease. About 150 adults who have already completed a previous fenofibrate study will take the combination and be …

This study tests whether adding fenofibrate to the standard drug ursodeoxycholic acid (UDCA) helps people with primary biliary cholangitis (PBC) who do not get enough benefit from UDCA alone. About 150 adults with PBC will receive either the combination or a placebo for up to 36 …

This study tests whether a probiotic called Clostridium butyricum can improve anxiety and depression in people with functional dyspepsia, a common stomach disorder. About 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication.…

This study tests a non-invasive brain stimulation method called tACS in 60 adults who have severe constipation that hasn't improved with standard treatments and also experience emotional distress. Participants receive either real or sham stimulation for 4 weeks. The goal is to se…

This study tests if a non-invasive device that gently stimulates a nerve in the ear can improve bowel movements in adults with severe constipation that hasn't responded to standard treatments. One hundred participants will be randomly assigned to receive either the active stimula…

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause). The trial will include 180 adults aged 18-80 who have mild to moderate anx…