Xiangya Hospital Of Central South University

This early-phase trial is testing whether a combination of two drugs—disitamab vedotin, given directly into the bladder, and toripalimab, given by infusion—can help people with a high-risk type of bladder cancer that has not spread into the muscle. The study includes patients who…

This trial tests a modified cardiopulmonary bypass (heart-lung machine) setup during emergency surgery for acute type A aortic dissection, a life-threatening condition. The new strategy aims to reduce the body's inflammatory response and lower the risk of new blood clots or embol…

This study compares two types of mesh used to repair a hidden hernia on the opposite side during surgery for a painful hernia. The goal is to see if a biologic mesh, made from pig tissue, causes less chronic pain at 6 months than a standard synthetic mesh. About 90 adults with on…

This study tests whether combining two drugs—camrelizumab (an immunotherapy) and rivoceranib (a targeted therapy)—with or without local treatments like surgery or radiation can shrink tumors in people with advanced liver cancer that has spread to the lungs. About 32 participants …

This phase 4 trial tests whether adding recaticimab to vunakizumab works better than vunakizumab alone for adults with moderate-to-severe plaque psoriasis and high cholesterol. Forty participants will be randomly assigned to receive either the drug combo or vunakizumab plus a pla…

This study will test the drug ivarmacitinib in 1,000 people aged 12 to 75 with moderate-to-severe atopic dermatitis (eczema). Participants take a daily pill for up to 52 weeks, with the option to adjust the dose. Researchers will measure how well the drug clears skin rashes and r…

This study tests a new infrared fluorescence staining technique that could help doctors diagnose prostate cancer faster during a biopsy. The method is compared to the standard frozen section analysis and the gold-standard paraffin section. If successful, it may offer a quicker, m…

This study tests a new blood test that combines genetic sequencing and immune response analysis to quickly tell if dead pancreatic tissue has become infected. Researchers will enroll 200 patients with severe pancreatitis across four hospitals. If accurate, this test could help do…

This study looks at whether three bedside ultrasound techniques—TCCD, ONSD, and ODH—can accurately detect high pressure inside the skull (intracranial hypertension) in people with traumatic brain injury. Researchers will compare these non-invasive methods to the standard invasive…

This trial tests whether one type of nerve block (intercostal) is as good as another (paravertebral) for controlling pain and keeping blood sugar levels stable in the first two days after minimally invasive lung surgery. The study involves 64 adults aged 18-70 who are scheduled f…

This study will test whether raising the head of the bed to 15 degrees reduces the chance of low oxygen levels during painless (sedated) gastroscopy and colonoscopy. About 400 adults will be randomly assigned to either a flat or slightly raised position. The goal is to see if thi…

This study will test whether giving paracetamol (a common painkiller) instead of a strong opioid (sufentanil) can reduce confusion and delirium in elderly patients after non-cardiac surgery. About 1,092 patients aged 60 and older will be randomly assigned to receive either parace…

This study looks at whether brain activity patterns, measured by EEG, can help predict long-term thinking problems in people with sepsis. Researchers will monitor brain waves for 72 hours in 78 ICU patients with different types of inflammation. They will then track cognitive func…

This observational study looks at adults with non-small cell lung cancer that has spread to the brain. Researchers want to see if getting radiation and immunotherapy 30 days apart or closer together changes how long the brain tumors stay stable and how long patients live. Partici…

This study will follow about 3,500 adults in China who have atrial fibrillation (an irregular heartbeat) along with metabolic disorders like obesity, diabetes, or high cholesterol. Researchers want to learn how these combined conditions affect risks for stroke, heart failure, and…