Tweaking the Heart-Lung machine: a new strategy to prevent Post-Surgery strokes and clots?
NCT ID NCT07750548
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests a modified cardiopulmonary bypass (heart-lung machine) setup during emergency surgery for acute type A aortic dissection, a life-threatening condition. The new strategy aims to reduce the body's inflammatory response and lower the risk of new blood clots or embolisms in the brain, heart, and other organs. Adults aged 18-80 undergoing this surgery may participate. The study compares the modified setup to the standard one, tracking new ischemic or embolic lesions and complications over three years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A modified cardiopulmonary bypass (heart-lung machine) setup designed to reduce inflammation and blood clotting during surgery.
- What this could lead to
- If successful, this approach could lower the risk of serious complications like strokes and blood clots after emergency aortic surgery, improving recovery and survival.
- What could go wrong
- The trial is still in early stages, and the modified bypass may not reduce inflammation or complications as hoped. There are also standard risks of major heart surgery, including bleeding and organ damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 270 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Jul 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2030
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 18 years old and under 80 years old, both male and female are eligible; 2. Patients planning to undergo open TAAAD surgery; 3. The patient voluntarily participates in this trial and signs an informed consent form. Exclusion Criteria: 1. History of tumors, mental illness, coagulation dysfunction, or hematological disorders; 2. Patients with preoperative thinking, language, or hearing communication disorders; 3. Severe preoperative liver and kidney dysfunction; 4. Critical preoperative states such as IABP, ECMO, and high-dose vasopressors; 5. Allergic to plastics, resins, or heparin; 6. Patients who refuse blood transfusions (Jehovah Witness); 7. Fever exceeding 38 ℃ or combined with systemic infection, sepsis; 8. Has participated in other blood related clinical studies. Eliminating criteria 1\) The patient requests revocation of informed consent and withdrawal from the study; 2) The included cases have had their surgeries cancelled due to various reasons, or the investigators believe that the intervention measures were not completed according to the plan; 3) The attending physician believes that continuing research is not beneficial for the patient.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Dissection, aortic are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.