Vanderbilt-ingram Cancer Center

This study tests whether analyzing the DNA of a kidney tumor can help doctors pick the most effective treatment for advanced or metastatic clear cell renal cell carcinoma. About 54 adults who have not had prior systemic therapy will receive one of two standard drug combinations: …

This study tests a drug called neratinib, which blocks a protein that helps cancer cells grow. It is given before usual treatment to 30 people with stage I-III HER2-mutated lobular breast cancer. The goal is to see if it works better than standard hormone therapy at shrinking tum…

This study tests a new approach called cryodevitalization, which freezes and kills early-stage lung cancer cells during a standard diagnostic procedure. About 30 people with stage I or II lung cancer will take part to see if the treatment is safe and feasible. The goal is to find…

This study tests whether removing as much tumor as possible with surgery before giving a special type of radiation therapy (PRRT) works better for people with advanced neuroendocrine tumors of the stomach, intestines, or pancreas. The radiation drug targets tumor cells and delive…

This early-stage trial tests whether a radioactive drug called 111In-panitumumab can help doctors find the first lymph nodes where head and neck cancer has spread. About 30 adults with head and neck cancer scheduled for surgery will receive the drug and then get a special scan (S…

This early-phase trial is testing whether combining two imaging techniques can help surgeons find and remove head and neck cancer more completely. About 40 adults with head and neck cancer will receive a special radioactive dye before surgery, followed by a fluorescent dye during…

This early-phase study tests whether a special radioactive tracer called [68Ga]Ga-ABY-025 can make HER2-positive tumors show up better on PET scans. About 30 adults with advanced or metastatic HER2-positive cancers (like breast, stomach, or head and neck cancer) who are already o…

This early-phase study tests a new radioactive tracer called [18F]NOTA-ABY030, which is designed to make head and neck squamous cell carcinoma show up more clearly on PET/CT scans. About 25 adults with suspicious or unclear findings on standard scans will receive the tracer and b…

This study collects and stores tissue samples from 3,000 people with melanoma to learn about the biological changes that happen as the disease starts and grows. The goal is to use this information to help doctors and patients make better treatment decisions. Participants provide …

This study tests a high-resolution PET-CT scanner that images removed tumors right in the operating room. About 50 adults with solid cancers will get a standard PET tracer before surgery, then the removed tissue is scanned to see if all cancer was taken out. The goal is to see if…

This study compares two ways of taking tissue samples from lung tumors: the standard needle method (EBUS-TBNA) and a newer freezing method (cryobiopsy). The goal is to see which method provides better samples for genetic testing, which helps doctors choose the right treatment. Ab…

This study follows 2,100 people of any age who have had sarcoma, a type of cancer, to see how the disease and its treatments affect them over time. Researchers will review medical records and ask patients about their health and lifestyle. The goal is to learn more about the long-…

This study follows 900 people who had retinoblastoma as children, along with their family members, to learn about long-term health, vision, and quality of life after treatment. Researchers collect vision tests, saliva and tissue samples, and questionnaires over time. The goal is …

This early-phase study tests a fluorescent dye attached to the cancer drug panitumumab to make head and neck cancer cells glow during surgery. About 18 adults scheduled for curative surgery will receive the dye infusion before their operation. The main goal is to find the best do…

This study collects and analyzes lung tissue from 4,000 people having surgery for early-stage non-small cell lung cancer. Researchers look for unique RNA and protein patterns (fingerprints) in the samples. The goal is to link these fingerprints to how the cancer behaves, such as …

This study collects blood, urine, sputum, and lung tissue from 4,000 adults at high risk for lung cancer. Researchers will analyze these samples to find DNA changes and other markers that could help predict how lung cancer develops. The goal is to learn more about the disease, no…

This study is building a registry of 10,000 adults interested in cancer genetics research. Participants fill out a consent form and questionnaires every two years—no treatments or procedures involved. The goal is to gather data for future studies on inherited cancer risks and to …

This study is creating a large collection of tissue, blood, and urine samples from up to 4,000 women with or without breast cancer. The goal is to provide researchers with a valuable resource to study the biology of breast cancer. Participants donate samples during routine care, …