University Of Oklahoma

This study tests whether giving antibiotics to obese first-time mothers during labor induction can lower their chance of needing a C-section. About 787 women with a BMI of 30 or higher will be randomly assigned to receive either antibiotics or a placebo. The goal is to see if thi…

This study tests a smoking cessation program designed for LGBTQ+ adults in Oklahoma, Texas, and Arkansas who experience high stress and low social support. Participants will receive nicotine replacement therapy and remote coaching to help them quit smoking. The goal is to reduce …

This study tests whether offering financial rewards helps couples who both smoke to quit. About 900 couples will be split into three groups: one gets standard quit-smoking help, another adds rewards for the quitting partner, and a third rewards both partners. The goal is to see w…

This study looks at whether eating more fiber and limiting when you eat can lower signs of cancer risk. Researchers will enroll 90 adults with obesity who currently eat little fiber. Participants will follow different diet plans to see how these changes affect weight, blood press…

This study tests whether a digital chest tube system (Thopaz+) works better than the standard analog system for children who need a chest tube after lung surgery or a collapsed lung. The digital system measures air leaks precisely and keeps steady suction, which may shorten how l…

This study is testing a mobile health app designed to help Black prostate cancer survivors (including those born in the U.S., Caribbean, or Africa) track and improve their quality of life. About 248 participants will use the app and provide feedback on how usable and helpful it i…

This study tests a new, pain-free exercise program for people with peripheral artery disease (PAD) who have leg pain when walking. The program aims to improve walking time and blood flow in the calf muscles. Researchers will compare the pain-free exercise group to a control group…

This study tests whether warming the contrast dye used during a hysterosalpingogram (HSG) — a standard fertility test that checks if fallopian tubes are open — can reduce pain and cramping. About 240 women aged 18 to 45 will be randomly assigned to receive either warm or room-tem…

This study looks at whether meloxicam, a different type of pain reliever, works better than the usual ibuprofen for pain after Mohs skin cancer surgery. About 300 adults having Mohs surgery will be split into three groups: one gets a low dose of meloxicam, another a higher dose, …

This study tests whether a device called the Buzzy System—a vibrating ice pack shaped like a bee—can reduce pain and fear in children aged 3 to 10 when their elbow fracture pins are removed. About 75 children will be involved, and researchers will measure pain and anxiety using s…

This study tests whether a special PET scan (18F FLT) can detect signs of leukemia or myeloma after treatment. About 60 people aged 4 to 80 with relapsed or hard-to-treat blood cancers will get the scan before and after therapy. Researchers will compare the scan results with stan…

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate how changing flavor availability mi…

This study looks at whether eating more fiber can help head and neck cancer patients avoid muscle loss (sarcopenia). Researchers will track 59 adults from diagnosis for six months, measuring their fiber intake, muscle mass, and inflammation. The goal is to understand the link bet…

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app will offe…

This study is testing a program to help Native American cancer patients get better coordinated care. It brings together a cancer center and tribal health systems to improve communication and support. About 187 adults newly diagnosed with cancer will take part. The goal is to see …

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, change brain reactions to smoking cues in daily smokers. About 80 healthy adults who smoke regularly will have MRI scans and report cravings. The goal is to understand the brain mechanis…

This study looks at whether practicing balance on a moving platform with limited vision can help older adults (65+) rely more on their body's sense of position and movement to stay steady. Thirty participants will train for two weeks, and researchers will measure changes in balan…

This study is for people with pancreatic cancer that can be surgically removed. Researchers will test blood samples for tiny pieces of tumor DNA (ctDNA) to see if they can predict how long patients live and how the disease responds to chemotherapy. The goal is to learn more about…

This study looks at tumor samples from 150 Native American patients with prostate cancer. Researchers want to find genetic differences that may affect how the cancer grows and responds to treatment. The goal is to learn more so that future care can be better tailored for this gro…

This pilot study tests whether shining a special near-infrared light on the head (called transcranial photobiomodulation, or tPBM) can improve blood flow and thinking in older adults. Thirty healthy volunteers aged 21-85 will receive either real or fake (sham) light sessions ever…

This study is looking for better ways to tell if new bone marrow cells are growing properly after a transplant. Researchers will use a special imaging scan (FLT PET/CT) and blood tests to check for early signs of graft failure. The goal is to find simple tests that help doctors d…

This study looks at how well creatine from gummies enters the blood compared to regular creatine powder. Sixteen healthy, active adults aged 18-45 will take both forms and have their blood levels measured. The goal is to see if the gummy form is absorbed similarly to the powder.