University Of Oklahoma

This study tests the safety and effectiveness of combining a short course of radiation (QUAD SHOT) with the immunotherapy drug pembrolizumab in 30 adults with recurrent head and neck cancer. The goal is to control the cancer and improve quality of life. Participants receive both …

This early-phase study tests the safety of combining two drugs, avelumab and AVB-S6-500, in adults with advanced urothelial carcinoma (bladder cancer) that has spread or cannot be removed by surgery. Participants must have already tried at least one platinum-based chemotherapy. T…

This study tests a new treatment plan for people with high-risk endometrial cancer who have already had surgery to remove the uterus. The plan combines an immunotherapy drug (pembrolizumab) with radiation to the vagina, followed by more immunotherapy plus chemotherapy. The goal i…

This study tests two drugs, atezolizumab and bevacizumab, given together to women with advanced, recurrent, or persistent endometrial cancer. The goal is to see if the combination can shrink tumors or slow cancer growth. About 110 women who have already tried at least one chemoth…

This study is testing a new imaging device called MSOT that uses light and sound to create detailed pictures of neck lymph nodes in people with head and neck cancer. The goal is to see if it can more accurately find cancer that has spread and also detect tissue damage from radiat…

This study tests whether a smartphone app designed for people with serious mental illness can help them quit smoking. About 64 adults who smoke heavily and have a mental illness will use one of two special apps or a standard app for 5 weeks. All participants also get nicotine pat…

This study works with the Choctaw Nation to help more people get screened for lung cancer. Lung cancer is a leading cause of death in American Indian and Alaska Native communities, and screening can catch it early. The program will identify who is eligible, help them schedule and…

This study looks at whether taking melatonin can change how your heart and blood vessels respond to a stressful situation, like putting your hand in cold water. Researchers will measure things like blood pressure and oxygen levels in muscles and the brain during rest and exercise…

This study planned to test whether an electromagnetic resonator could change how the autonomic nervous system works in people with heart failure. It would have included 20 heart failure patients and 20 healthy volunteers. However, the study was withdrawn before enrolling any part…

This study looks at whether an autoimmune reaction (where the body attacks itself) causes symptoms of postural tachycardia syndrome (POTS), a condition that makes your heart race when you stand up. Researchers will test if stimulating the vagus nerve with mild electrical pulses c…

This study looks back at medical records of 72 American Indian patients treated with immunotherapy for cancers like lung, melanoma, and kidney cancer. Researchers want to see how well these treatments work compared to White patients and identify any differences in care. The goal …